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Total 88 results found since Jan 2013.

Efficacy of the sphingosine-1-phosphate receptor agonist fingolimod in animal models of stroke: an updated meta-analysis
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Source: International Journal of Neuroscience - March 8, 2020 Category: Neuroscience Authors: Chun Dang Yaoheng Lu Qian Li Chunyang Wang Xiaofeng Ma Source Type: research

Fingolimod promotes angiogenesis and attenuates ischemic brain damage via modulating microglial polarization.
CONCLUSIONS: Our research indicated that FTY720 treatment promoted angiogenesis via microglial M2 polarization and exerted neuroprotection in PT ischemic stroke. PMID: 31626784 [PubMed - as supplied by publisher]
Source: Brain Research - October 14, 2019 Category: Neurology Authors: Shang K, He J, Zou J, Qin C, Lin L, Zhou LQ, Yang LL, Wu LJ, Wang W, Zhan KB, Tian DS Tags: Brain Res Source Type: research

Repurposing multiple sclerosis drugs: a review of studies in other neurological and psychiatric conditions.
Abstract Treatment options for multiple sclerosis (MS) have improved in the past 20 years, with new oral disease-modifying drugs and monoclonal antibodies becoming available. The success seen with these drugs in MS, and their various mechanisms of action, has led to them being investigated in other neurological and psychiatric disorders. This review article summarises the ongoing and completed studies of MS drugs in neurological and psychiatric conditions other than MS. The most promising results are for interferon beta in human T cell leukaemia virus 1 associated myelopathy/tropical spastic paraparesis and glioma...
Source: Drug Discovery Today - May 13, 2019 Category: Drugs & Pharmacology Authors: Rommer PS, Sellner J Tags: Drug Discov Today Source Type: research

Fingolimod enhances the efficacy of delayed alteplase administration in acute ischemic stroke by promoting anterograde reperfusion and retrograde collateral flow
ObjectiveThe present study was undertaken to determine the efficacy of coadministration of fingolimod with alteplase in acute ischemic stroke patients in a delayed time window.MethodsThis was a prospective, randomized, open ‐label, blinded endpoint clinical trial, enrolling patients with internal carotid artery or middle cerebral artery proximal occlusion within 4.5 to 6 hours from symptom onset. Patients were randomly assigned to receive alteplase alone or alteplase with fingolimod. All patients underwent pretreatme nt and 24‐hour noncontrast computed tomography (CT)/perfusion CT/CT angiography. The coprimary endpoint...
Source: Annals of Neurology - November 2, 2018 Category: Neurology Authors: De ‐Cai Tian, Kaibin Shi, Zilong Zhu, Jia Yao, Xiaoxia Yang, Lei Su, Sheng Zhang, Meixia Zhang, Rayna J. Gonzales, Qiang Liu, DeRen Huang, Michael F. Waters, Kevin N. Sheth, Andrew F. Ducruet, Ying Fu, Min Lou, Fu‐Dong Shi Tags: Research Article Source Type: research

Fingolimod Enhances the Efficacy of Delayed Alteplase Administration in Acute Ischemic Stroke by Promoting Anterograde Reperfusion and Retrograde Collateral Flow
Annals of Neurology,Volume 0, Issue ja, -Not available-.
Source: Annals of Neurology - October 8, 2018 Category: Neurology Authors: De ‐Cai Tian, Kaibin Shi, Zilong Zhu, Jia Yao, Xiaoxia Yang, Lei Su, Sheng Zhang, Meixia Zhang, Rayna J. Gonzales, Qiang Liu, DeRen Huang, Michael F. Waters, Kevin N. Sheth, Andrew F. Ducruet, Ying Fu, Min Lou, Fu‐Dong Shi Source Type: research

S1PR3 is essential for phosphorylated fingolimod to protect astrocytes against oxygen-glucose deprivation-induced neuroinflammation via inhibiting TLR2/4-NF κB signalling.
This study was intended to investigate the mechanisms of phosphorylated FTY720 (pFTY720), which was the principle active molecule in regulating astrocyte-mediated inflammatory responses induced by oxygen-glucose deprivation (OGD). Results demonstrated that pFTY720 could protect astrocytes against OGD-induced injury and inflammatory responses. It significantly decreased pro-inflammatory cytokines, including high mobility group box 1 (HMGB1) and tumour necrosis factor-α (TNF-α). Further, studies displayed that pFTY720 could prevent up-regulation of Toll-like receptor 2 (TLR2), phosphorylation of phosphoinositide 3-kinase (...
Source: J Cell Mol Med - March 13, 2018 Category: Molecular Biology Authors: Dong YF, Guo RB, Ji J, Cao LL, Zhang L, Chen ZZ, Huang JY, Wu J, Lu J, Sun XL Tags: J Cell Mol Med Source Type: research

S1PR3 is essential for phosphorylated fingolimod to protect astrocytes against oxygen ‐glucose deprivation‐induced neuroinflammation via inhibiting TLR2/4‐NFκB signalling
This study was intended to investigate the mechanisms of phosphorylated FTY720 (pFTY720), which was the principle active molecule in regulating astrocyte‐mediated inflammatory responses induced by oxygen‐glucose deprivation (OGD). Results demonstrated that pFTY720 could protect astrocytes against OGD‐induced injury and inflammatory responses. It significantly decreased pro‐inflammatory cytokines, including high mobility group box 1 (HMGB1) and tumour necrosis factor‐α (TNF‐α). Further, studies displayed that pFTY720 could prevent up‐regulation of Toll‐like receptor 2 (TLR2), phosphorylation of phosphoinos...
Source: Journal of Cellular and Molecular Medicine - March 13, 2018 Category: Molecular Biology Authors: Yin ‐Feng Dong, Ruo‐Bing Guo, Juan Ji, Lu‐Lu Cao, Ling Zhang, Zheng‐Zhen Chen, Ji‐Ye Huang, Jin Wu, Jun Lu, Xiu‐Lan Sun Tags: ORIGINAL ARTICLE Source Type: research

Fingolimod Protects Against Ischemic White Matter Damage by Modulating Microglia Toward M2 Polarization via STAT3 Pathway Basic Sciences
Conclusions—Our study suggested that FTY720 might be a potential therapeutic drug targeting brain inflammation by skewing microglia toward M2 polarization after chronic cerebral hypoperfusion.
Source: Stroke - November 27, 2017 Category: Neurology Authors: Chuan Qin, Wen-Hui Fan, Qian Liu, Ke Shang, Madhuvika Murugan, Long-Jun Wu, Wei Wang, Dai-Shi Tian Tags: Ischemic Stroke, Vascular Disease Original Contributions Source Type: research

Fingolimod Confers Neuroprotection through Activation of Rac1 after Experimental Germinal Matrix Hemorrhage in Rat Pups
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - December 31, 2016 Category: Neurology Authors: William B. Rolland, Paul R. Krafft, Tim Lekic, Damon Klebe, Julia LeGrand, Abby Jones Weldon, Liang Xu, John H. Zhang Tags: Original Article Source Type: research

Selective Sphingosine 1-Phosphate Receptor 1 Agonist Is Protective Against Ischemia/Reperfusion in Mice Brief Report
Conclusions—The selective S1P1 agonist LASW1238 reduces infarct volume after ischemia/reperfusion in mice, but only when lymphopenia is sustained for at least 24 hours. S1P1 and lymphocytes are potential targets for drug treatment in stroke. Defining the best drug dosing regimens to control the extent and duration of lymphopenia is critical to achieve the desired effects.
Source: Stroke - November 27, 2016 Category: Neurology Authors: Vanessa H. Brait, Gema Tarrason, Amadeu Gavalda, Nuria Godessart, Anna M. Planas Tags: Basic Science Research, Inflammation, Ischemia Brief Reports Source Type: research

Blockage of central sphingosine-1-phosphate receptor does not abolish the protective effect of FTY720 in early brain injury after experimental subarachnoid hemorrhage.
CONCLUSION: The present study suggests that systemic administration of FTY720 reduces EBI after SAH and that the effect might not come from central S1P activation but be associated with peripheral effects such as immunomodulation. PMID: 27605019 [PubMed - as supplied by publisher]
Source: Current Drug Delivery - September 5, 2016 Category: Drugs & Pharmacology Authors: Hasegawa Y, Uekawa K, Kawano T, Suzuki H, Kim-Mitsuyama S Tags: Curr Drug Deliv Source Type: research

Mechanism of Action and Clinical Potential of Fingolimod for the Treatment of Stroke
Wentao Li, Haoliang Xu, Fernando D. Testai
Source: Frontiers in Neurology - August 25, 2016 Category: Neurology Source Type: research

Fingolimod (FTY720) reduces cortical infarction and neurological deficits during ischemic stroke through potential maintenance of microvascular patency.
Abstract Fingolimod (FTY720) a functional sphingosine-1-phosphate receptor 1 (S1P1) antagonist reduces infarct volume and improves neurological deficits in different rodent stroke models by modulating inflammatory and immune processes. However, studies on FTY720 regarding its non-immunological efficacy on ischemic cerebral tissue are sparse. Here we investigated whether FTY720 has cytoprotective and restorative properties following ischemic stroke in mice. Male C57Bl/6 mice received FTY720 (1mg/kg) or a vehicle solution intraperitoneally immediately prior to transient middle cerebral artery occlusion (tMCAO; 30 mi...
Source: Current Neurovascular Research - August 22, 2016 Category: Neurology Authors: Fluri F, Schuhmann MK, Krstić M, Kleinschnitz C Tags: Curr Neurovasc Res Source Type: research

Clinical Trials of Immunomodulation in Ischemic Stroke
Abstract Inflammatory mechanisms are currently considered as a prime target for stroke therapy. There is evidence from animal studies that immune signals and mediators can have both detrimental and beneficial effects in particular stages of the disease process. Moreover, several of these mechanisms are turned on with sufficient delay after ischemia onset to make them amenable to therapeutic intervention. Several clinical proof-of concept trials have investigated the efficacy of different immunomodulatory approaches in patients with stroke. Trials targeting the innate immune system have focused on reduction of micr...
Source: Neurotherapeutics - July 12, 2016 Category: Neurology Source Type: research

Selective Sphingosine-1-Phosphate Receptor 1 Modulation Attenuates Experimental Intracerebral Hemorrhage Basic Sciences
Conclusions— S1PR1 modulation via RP101075 provides protection in experimental ICH. Together with the advantageous pharmacological features of RP101075, these results warrant further investigations of its mechanisms of action and translational values in ICH patients.
Source: Stroke - June 26, 2016 Category: Neurology Authors: Sun, N., Shen, Y., Han, W., Shi, K., Wood, K., Fu, Y., Hao, J., Liu, Q., Sheth, K. N., Huang, D., Shi, F.-D. Tags: Intracranial Hemorrhage Basic Sciences Source Type: research