Selective Sphingosine 1-Phosphate Receptor 1 Agonist Is Protective Against Ischemia/Reperfusion in Mice [Brief Report]

Conclusions—The selective S1P1 agonist LASW1238 reduces infarct volume after ischemia/reperfusion in mice, but only when lymphopenia is sustained for at least 24 hours. S1P1 and lymphocytes are potential targets for drug treatment in stroke. Defining the best drug dosing regimens to control the extent and duration of lymphopenia is critical to achieve the desired effects.

http://stroke.ahajournals.org/content/47/12/3053.short?rss=1

Source: Stroke - November 27, 2016 Category: Neurology Authors: Vanessa H. Brait, Gema Tarrason, Amadeu Gavalda, Nuria Godessart, Anna M. Planas Tags: Basic Science Research, Inflammation, Ischemia Brief Reports Source Type: research