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Drug: Amantadine

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Total 14 results found since Jan 2013.

Amantadine for NeuroenhaNcement in acutE patients Study - a protocol for a prospective pilot proof of concept phase IIb study in intensive and intermediate care unit patients (ANNES)
Persisting coma is a common complication in (neuro)intensive care in neurological disease such as acute ischemic stroke, intracerebral hemorrhage or subarachnoid hemorrhage. Amantadine acts as a nicotinic rece...
Source: BMC Neurology - August 22, 2023 Category: Neurology Authors: Anna Hofmann, Corinna Blum, Constanze Single, Kamal Adeyemi, Patricia Schwarz, Vasileios Siokas, Tim W. Rattay, Helene A. H äberle, Reimer Riessen, Bettina Brendel, Iris Haug, Ruth Bösel, Manola Zago, Peter Martus, Ulf Ziemann, Annerose Mengel & hellip; Tags: Study Protocol Source Type: research

Serendipity and Observations in Functional Neurosurgery: From James Parkinson ’s Stroke to Hamani’s & amp; Lozano ’s Flashbacks
Background: Serendipity and observations have a noble tradition in medicine, including neurology, and are responsible for many medical treatments (carbamazepine for tic douloureux, amantadine for Parkinson ’s disease, gabapentin for restless legs…). We aimed at examining the contribution of serendipity and observations to functional neurosurgery. Scholarly publications relevant to the history of functional neurosurgery for movement and psychiatric disorders were reviewed, starting from the pre-ste reotactic era. The documents were scrutinized with respect to indications for surgery, surgical methods, and brain targets,...
Source: Stereotactic and Functional Neurosurgery - July 26, 2022 Category: Neurosurgery Source Type: research

Amantadine treatment is associated with improved consciousness in patients with non-traumatic brain injury
Conclusions Amantadine treatment is associated with improved consciousness among patients with different types of non-traumatic brain injury in this observational cohort analysis. Epileptic seizures should be considered as potential side effects and randomised controlled trials are needed to confirm these findings.
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Rühl, L., Kuramatsu, J. B., Sembill, J. A., Kallmünzer, B., Madzar, D., Gerner, S. T., Giede-Jeppe, A., Balk, S., Mueller, T., Jäger, J., Schwab, S., Huttner, H. B., Sprügel, M. I. Tags: Open access Cerebrovascular disease Source Type: research

Delayed gait recovery by resolution of limb-kinetic apraxia in a chronic hemiparetic stroke patient: A case report
Rationale: This paper reports on a chronic hemiparetic stroke patient who showed delayed gait recovery due to resolution of limb-kinetic apraxia (LKA). Patient concerns: A 49-year-old man underwent comprehensive rehabilitation at a local rehabilitation hospital since 3 weeks after spontaneous intracerebral haemorrhage. However, he could not walk independently because of severe motor weakness in his right leg until 19 months after the onset. Diagnosis: At the beginning of rehabilitation at our hospital (19 months after onset), we thought that he had the neurological potential to walk independently beca...
Source: Medicine - January 28, 2022 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

A Review of Pharmacologic Neurostimulant Use During Rehabilitation and Recovery After Brain Injury.
CONCLUSIONS: The pharmacologic agent with the most supporting literature is amantadine used for cognitive improvement after TBI. Other neurostimulants with positive, despite more limited, evidence include methylphenidate, modafinil, levodopa, and citalopram. Caution is warranted with other neurostimulants given higher rates of adverse effects or lack of benefit observed in clinical trials. PMID: 33435717 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - January 12, 2021 Category: Drugs & Pharmacology Authors: Kakehi S, Tompkins DM Tags: Ann Pharmacother Source Type: research

Thalamic Dementia in Acute Inpatient Rehabilitation—Role for Amantadine?
In this report, we present a case of bilateral thalamic infarcts resulting in thalamic dementia with severe behavioral manifestations in a 64-yr-old man with no preexisting neuropsychiatric comorbidities. A trial of amantadine, a dopamine-promoting agent, in the acute rehabilitation unit in an attempt to manage his agitation led to multiple weeks of dramatic behavioral improvement and increased participation in therapies. Dopamine receptors are believed to be present at increased densities in thalamic nuclei with mesolimbic projections, suggesting that they are able to modulate limbic functions such as arousal, emotion, an...
Source: American Journal of Physical Medicine and Rehabilitation - December 20, 2020 Category: Rehabilitation Tags: Case Reports Source Type: research

Topographical data analysis to identify high-density clusters in stroke patients undergoing post-acute rehabilitation.
CONCLUSION: This study revealed that in addition to functional status on admission, stroke risk factors are associated with recovery outcomes. Future studies using TDA to analyze omic data, including clinical, biological, and sociodemographic factors, will accelerate the development of personalized treatment plans in post-acute stroke rehabilitation patients. PMID: 33118467 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - October 29, 2020 Category: Neurology Authors: Bose E, Wood LJ, Wang QM Tags: Top Stroke Rehabil Source Type: research

Amantadine and Modafinil as Neurostimulants Following Acute Stroke: A Retrospective Study of Intensive Care Unit Patients
ConclusionsNeurostimulant administration during acute stroke care may improve wakefulness. Future controlled studies with a neurostimulant administration protocol, prospective evaluation, and discretely defined response and safety criteria are needed to confirm these encouraging findings.
Source: Neurocritical Care - May 19, 2020 Category: Neurology Source Type: research

Amantadine and Modafinil as Neurostimulants During Post-stroke Care: A Systematic Review
AbstractAmantadine and modafinil are neurostimulants that may improve cognitive and functional recovery post-stroke, but the existing study results vary, and no comprehensive review has been published. This systematic review describes amantadine and modafinil administration practices post-stroke, evaluates timing and impact on clinical effectiveness measures, and identifies the incidence of potential adverse drug effects. A librarian-assisted search of the MEDLINE (PubMed) and EMBASE databases identified all English-language publications with “amantadine” or “modafinil” in the title or abstract from inception throu...
Source: Neurocritical Care - May 11, 2020 Category: Neurology Source Type: research

Amantadine and memantine: a comprehensive review for acquired brain injury.
Authors: Ma HM, Zafonte RD Abstract This comprehensive review discusses clinical studies of patients following brain injuries (traumatic, acquired, or stroke), who have been treated with amantadine or memantine. Both amantadine and memantine are commonly used in the acute rehabilitation setting following brain injuries, despite their lack of FDA-approval for neuro-recovery. Given the broad utilization of such agents, there is a need to review the evidence supporting this common off-label prescribing. The purpose of this review is to describe the mechanisms of action for memantine and amantadine, as well as to compl...
Source: Brain Injury - February 22, 2020 Category: Neurology Tags: Brain Inj Source Type: research

Stroke patient speaks due to Parkinson's disease drug
An unnamed patient, 36, believed to be from Berlin, who was only being kept alive by medical intervention, was able to speak in short sentences after being given the drug amantadine.
Source: the Mail online | Health - July 26, 2017 Category: Consumer Health News Source Type: news

Update on pharmacotherapy for stroke and traumatic brain injury recovery during rehabilitation
This article evaluates whether specific drugs are able to facilitate motor recovery after stroke or improve the level of consciousness, cognitive, or behavioral symptoms after traumatic brain injury. Recent findings: After stroke, serotonin reuptake inhibitors can enhance restitution of motor functions in depressed as well as in nondepressed patients. Erythropoietin and progesterone administered within hours after moderate to severe traumatic brain injury failed to improve the outcome. A single dose of zolpidem can transiently improve the level of consciousness in patients with vegetative state or minimally conscious stat...
Source: Current Opinion in Neurology - November 8, 2016 Category: Neurology Tags: TRAUMA AND REHABILITATION: Edited by Bruce H. Dobkin Source Type: research

The effectiveness of dopamine agonists for treatment of neuropsychiatric symptoms post brain injury and stroke.
CONCLUSION: Our systematic review demonstrates an evolving evidence base to suggest some benefits in agitation and aggression, mood and attentional deficits. However, there are key limitations of the studies undertaken to date involving small numbers of participants, heterogeneous outcome measures, and variable study designs. There is a need for on-going large prospective double-blind RCTs in these medications using standardised criteria and outcomes to fully understand their effectiveness in this patient group. PMID: 25850757 [PubMed - as supplied by publisher]
Source: Acta Neuropsychiatrica - April 11, 2015 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Perindopril increases the swallowing reflex by inhibiting substance P degradation and tyrosine hydroxylase activation in a rat model of dysphagia.
Abstract Patients with hypertension have a high risk of ischemic stroke and subsequent stroke-associated pneumonia. Stroke-associated pneumonia is most likely to develop in patients with dysphagia. The present study was designed to compare the ameliorative effects of different treatments in rat model of dysphagia. Spontaneously hypertensive rats were treated with bilateral common carotid artery occlusion (BCAO) to induce chronic cerebral hypoperfusion causing disorders of the swallowing reflex. Angiotensin-converting enzyme (ACE) inhibitors (perindopril, imidapril and enalapril), an angiotensin II type 1-receptor ...
Source: European Journal of Pharmacology - November 12, 2014 Category: Drugs & Pharmacology Authors: Ikeda JI, Kojima N, Saeki K, Ishihara M, Takayama M Tags: Eur J Pharmacol Source Type: research