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Total 340 results found since Jan 2013.

NHLBI-Sponsored Randomized Trial of Postconditioning During Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction.
CONCLUSIONS: We found no early benefit of PostC on infarct size, MSI and LV function compared to routine PCI. However, PostC was associated with improved LV remodeling at one year of follow-up, especially in subjects with MVO. PMID: 30602360 [PubMed - as supplied by publisher]
Source: Circulation Research - January 3, 2019 Category: Cardiology Authors: Traverse JH, Swingen C, Henry TD, Fox J, Wang Y, Chavez IJ, Lips DL, Lesser JR, Pedersen WR, Burke NM, Pai A, Lindberg JL, Garberich R Tags: Circ Res Source Type: research

Early versus late clinical outcomes following same day discharge after elective percutaneous coronary intervention: A systematic review and meta-analysis
Conclusions: In those patients who were discharged from the hospital on the same day following elective PCI, no significant difference was observed in the assessed early versus late clinical outcomes. However, late clinical outcomes resulted in a significantly higher rate of re-hospitalization. Larger studies should confirm this hypothesis.
Source: Medicine - January 1, 2019 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Not Just Acid Reflux: The Need to Think Worst First
Discussion Heart disease is the leading cause of death in the United States.1 This year, 720,000 Americans will have a new coronary event—defined as first hospitalized myocardial infarction (MI) or coronary heart disease death—and around 335,000 will have a recurrent event. Approximately 35% of people who experience a coronary event in a given year and around 14% of patients who have an acute coronary syndrome will die from it.1 Roughly 60% of patients with an acute coronary syndrome are transported to the emergency department via ambulance.2–4. Up to one-third of patients experiencing an MI may not complain of chest...
Source: JEMS Special Topics - January 13, 2019 Category: Emergency Medicine Authors: Stephen Sanko, MD, FACEP Tags: Exclusive Articles Cardiac & Resuscitation Source Type: news

Perioperative Management For the Cocaine-Positive Patient Undergoing Elective Surgery Under General Anesthesia
Cocaine use in the United States is widespread and on the rise.1,2 Due to the increased prevalence of cocaine use, it is likely that the oral and maxillofacial surgeon (OMS) will come across multiple instances of cocaine-positive patients presenting for elective surgery. Studies have already shown that many oral and maxillofacial surgery cases are cancelled due to the presence of cocaine metabolites in urine tests.1,3 Cocaine is a known risk factor for cardiovascular complications (eg, stroke, myocardial infarction, dysrhythmia, angina, hypertension, tachycardia, prolonged QT interval, coronary vasospasm, and aortic dissec...
Source: Journal of Oral and Maxillofacial Surgery - January 17, 2019 Category: ENT & OMF Authors: Nicholas P. Saggese, Christopher Chang, Vito A. Cardo Source Type: research

Lipids, Apolipoproteins, and Risk of Atherosclerotic Cardiovascular Disease in Persons With CKD
ConclusionsHigher VLDL-C and Apo-B levels, as well as lower HDL-C and Apo-AI levels, are associated with increased risk for ASCVD. These findings support future investigations into pharmacologic targeting of lipoproteins beyond LDL-C, such as triglyceride-rich lipoproteins, to reduce residual risk for ASCVD among individuals with CKD.
Source: American Journal of Kidney Diseases - January 25, 2019 Category: Urology & Nephrology Source Type: research

Acute Vascular Ischemic Events in Patients with Central Retinal Artery Occlusion in the United States: A Nationwide Study 2003-2014
Central retinal artery occlusion (CRAO) confers a high risk of acute vascular ischemic events, including stroke and myocardial infarction (MI). Understanding the burden and risk factor profile of these ischemic events can serve as a valuable guide for ophthalmologists in the management and appropriate referral of these patients.
Source: American Journal of Ophthalmology - January 26, 2019 Category: Opthalmology Authors: Tahreem A. Mir, Ahmad Z. Arham, Wei Fang, Fahad Alqahtani, Mohamad Alkhouli, Julia Gallo, David M. Hinkle Tags: Original Articles Source Type: research

Companies rally around American Heart Association ’s campaign to support research and education during February
Every 40 seconds, someone in America has a stroke or a heart attack. Less than one third of high school students get the recommended amount of daily physical activity and 30 million people in the United States have no easy access to healthy food. The American Heart Association, the world’s leading voluntary organization focused on heart and brain health, is on a mission to improve these statistics, and has teamed up with more than 70 companies around the country to do so through the Life Is Why…
Source: bizjournals.com Health Care:Physician Practices headlines - February 19, 2019 Category: American Health Authors: Metro Atlanta American Heart Association Source Type: news

Hospital costs associated with intraoperative hypotension among non-cardiac surgical patients in the US: a simulation model.
CONCLUSIONS: The model results suggest improved intraoperative hypotension control in a hospital with annual volume 10,000 non-cardiac surgical patients is associated with mean cost reductions ranging from $1.2 to $4.6 million per year. Since the magnitude of the RCT mean estimate is similar to the unadjusted observational model, the institutional costs are likely at the upper end of this range. PMID: 30838899 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - March 7, 2019 Category: Health Management Tags: J Med Econ Source Type: research

NAEMT and Sepsis Alliance Announce Results of National Sepsis Survey
In a recent national survey of more than 1,300 EMS providers, the National Association of Emergency Medical Technicians (NAEMT) in association with the Sepsis Alliance found that although nearly all respondents (98%) consider sepsis a medical emergency, only about half (51%) feel very confident in their ability to recognize symptoms of sepsis—the body’s life-threatening response to an infection. Each year, about 1.7 million people in the United States are diagnosed with sepsis, with 270,000 dying, making sepsis a priority public health issue. This is reflected in the 83% of respondents who say that they’ve seen sepsi...
Source: JEMS Patient Care - March 15, 2019 Category: Emergency Medicine Authors: JEMS Staff Tags: Patient Care News Source Type: news

Optimizing the treatment of pain and anxiety in pediatric emergencies: the role of accreditation
AbstractPervasive disparities exist in the treatment of pain and anxiety in pediatric patients presenting to hospitals with emergency conditions. This finding has been demonstrated worldwide, and is especially exacerbated in general emergency departments, which treat both adults and children. Policies to promote appropriate analgesia in the context of pediatric emergency care have been developed by several professional societies and governmental agencies in the United States; however, progress has been uneven, and data regarding these questions is lacking.In their excellent article, Capua and her co-authors address this pr...
Source: Israel Journal of Health Policy Research - April 7, 2019 Category: International Medicine & Public Health Source Type: research

YiQiFuMai Powder Injection Attenuates Coronary Artery Ligation-Induced Heart Failure Through Improving Mitochondrial Function via Regulating ROS Generation and CaMKII Signaling Pathways
This study was carried out in accordance with the recommendations of “Guide for the Care and Use of Laboratory Animals, National Institutes of Health.” The protocol was approved by the “China Pharmaceutical University.” Surgical Preparation The mice were anesthetized with chloral hydrate (4% chloral hydrate, ip). The HF model was induced by CAL as previously reported (Gao et al., 2010). Successful ligation of the coronary artery was confirmed by the occurrence of ST-segment elevation in electrocardiogram. Sham operated mice were performed the same process except left CAL. After ligation, the h...
Source: Frontiers in Pharmacology - April 9, 2019 Category: Drugs & Pharmacology Source Type: research

Blood Flow Restriction Exercise Attenuates the Exercise-Induced Endothelial Progenitor Cell Response in Healthy, Young Men
Conclusion In summary, this is the first study to show that BFR exercise did not augment EPC response to exercise, and in fact blunted the EPC response to low load unilateral KE exercise in young, healthy males. Ethics Statement This study was carried out in accordance with the recommendations of Edinburgh Napier University Research and Ethics Governance Committee. The study was ethically approved by Edinburgh Napier University Research and Ethics Governance Committee. All participants gave written informed consent in accordance with the Declaration of Helsinki. Author Contributions MR, RM, AP, CW, GF-J designed the s...
Source: Frontiers in Physiology - April 16, 2019 Category: Physiology Source Type: research

Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats
Conclusion Principal findings of this work are that abnormal Ca2+ transient amplitude, contractile dysfunction; and impaired relaxation of MetS cardiomyocytes underlies intrinsic dysfunctional RyR2 and SERCA pump. Abnormal activity of RyRs was evidenced by its decreased ability to bind [3H]-ryanodine. Although the MetS condition does not modify RyR2 protein expression, its phosphorylation at Ser2814 is decreased, which impairs its capacity for activation during ECC. The dysfunctional RyRs, together with a decreased activity of SERCA pump due to decreased Thr17-PLN phosphorylation suggest a downregulation of CaMKII in MetS...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research

Sex Difference of Radiation Response in Occupational and Accidental Exposure
Conclusion and Outlook This review summarizes the data from major human studies on the health risks of radiation exposure and shows that sex can potentially influence the prolonged response to radiation exposure (Figure 1 and Tables 1, 2). These data suggest that long-term radiosensitivity in females is higher than that in males who receive a comparable dose of radiation. Our analysis of the literature agrees with the conclusions of the recent report on the Biological effects of ionizing radiation (BEIR VII) published in 2006 by the National Academy of Sciences (NAS), United States (National Research Council, 2006). The B...
Source: Frontiers in Genetics - May 2, 2019 Category: Genetics & Stem Cells Source Type: research