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Total 340 results found since Jan 2013.

Economic burden associated with inadequate antidepressant medication management among patients with depression and known cardiovascular diseases: insights from a united states based retrospective claims database analysis.
Conclusions: Among post-MI and post-stroke patients, inadequate MDD care was associated with a significantly higher economic burden. PMID: 31665949 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - November 2, 2019 Category: Health Management Tags: J Med Econ Source Type: research

Geographical variations in left main coronary artery revascularisation: a pre-specified analysis of the EXCEL trial
CONCLUSIONS: In the EXCEL trial, the relative risks for the 30-day and five-year primary composite outcome of death, MI or stroke after PCI versus CABG were consistent irrespective of geography. However, five-year rates of IDR after PCI were significantly higher in NA centres, a finding the Heart Team and patients should consider when making treatment decisions. ClinicalTrials.gov identifier: NCT01205776.PMID:34212863 | DOI:10.4244/EIJ-D-21-00338
Source: EuroIntervention - July 2, 2021 Category: Cardiovascular & Thoracic Surgery Authors: Aung Myat David Hildick-Smith Adam J de Belder Uday Trivedi Aaron Crowley Marie-Claude Morice David E Kandzari Nicholas J Lembo W Morris Brown Patrick W Serruys Arie Pieter Kappetein Joseph F Sabik Gregg W Stone Source Type: research

Meta ‐Analysis of Clinical Outcomes of PCSK9 Modulators in Patients with Established ASCVD
ConclusionThese findings suggest a class effect for favorable lipid changes and a low risk of serious adverse events among pharmacologic agents targeting PCSK9. Although there is compelling evidence that PCSK9-targeting agents reduce the risk of some cardiovascular outcomes, adequately powered studies with longer follow-up may be needed to fully characterize the magnitude of benefits across the cardiovascular spectrum.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 17, 2021 Category: Drugs & Pharmacology Authors: Azita H. Talasaz, Ai ‐Chen (Jane) Ho, Fawzia Bhatty, Rachel A. Koenig, Dave L. Dixon, William L. Baker, Benjamin W. Van Tassell Tags: TI ON ADVANCES IN CARDIOVASCULAR PHARMACOTHERAPY Source Type: research

Meta ‐analysis of clinical outcomes of PCSK9 modulators in patients with established ASCVD
AbstractThe advent of monoclonal antibodies targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) ushered in a new era of dyslipidemia pharmacotherapy. The first two antibodies targeting PCSK9 (evolocumab, alirocumab) approved by the United States Food and Drug Administration (FDA) provided significant and sustained reductions in atherogenic lipids and a reduced risk of atherosclerotic cardiovascular disease (ASCVD) events. More recently, phase 3 trials of inclisiran —a small interfering RNA-based agent targeting PCSK9—reported similar lipid-lowering effects and preliminary evidence of ASCVD risk reduction, a...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - October 30, 2021 Category: Drugs & Pharmacology Authors: Azita H. Talasaz, Ai ‐Chen (Jane) Ho, Fawzia Bhatty, Rachel A. Koenig, Dave L. Dixon, William L. Baker, Benjamin W. Van Tassell Tags: TI ON ADVANCES IN CARDIOVASCULAR PHARMACOTHERAPY Source Type: research

Medicare Bundled Payment Policy on Anemia Care, Major Adverse Cardiovascular Events, and Mortality among Adults Undergoing Hemodialysis
CONCLUSIONS: The Medicare reimbursement policy and Food and Drug Administration-recommended erythropoietin-stimulating agent dosing changes were associated with lower erythropoietin-stimulating agent use and lower hemoglobin levels. These changes in anemia care were associated with lower risks of major adverse cardiovascular event, stroke, mortality, and heart failure but higher risk of acute myocardial infarction among adults receiving hemodialysis.PMID:35589388 | DOI:10.2215/CJN.14361121
Source: Clinical Journal of the American Society of Nephrology : CJASN - May 19, 2022 Category: Urology & Nephrology Authors: Haesuk Park Raj Desai Xinyue Liu Steven M Smith Juan Hincapie-Castillo Linda Henry Amie Goodin Saraswathi Gopal Carl J Pepine Raj Mohandas Source Type: research

Outcomes of Early Rhythm Control Therapy in Patients With Atrial Fibrillation and a High Comorbidity Burden in Large Real-World Cohorts
CONCLUSIONS: ERC is safe and may be more favorable in a population-based sample of patients with high a comorbidity burden (CHA2DS2-VASc score ≥4).PMID:36942567 | DOI:10.1161/CIRCEP.122.011585
Source: Cancer Control - March 21, 2023 Category: Cancer & Oncology Authors: Jannis Dickow Shinwan Kany Victor Roth Cardoso Patrick T Ellinor Georgios V Gkoutos Holly K Van Houten Paulus Kirchhof Andreas Metzner Peter A Noseworthy Xiaoxi Yao Andreas Rillig Source Type: research

Differences in baseline characteristics, practice patterns and clinical outcomes in contemporary coronary artery bypass grafting in the United States and Europe: insights from the SYNTAX randomized trial and registry ADULT CARDIAC
CONCLUSIONS Repeat revascularization rates following CABG in the USA versus Europe were increased at 5 years, particularly in off-pump patients. There was no significant difference in the rate of death, stroke and MI.
Source: European Journal of Cardio-Thoracic Surgery - March 13, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Head, S. J., Parasca, C. A., Mack, M. J., Mohr, F. W., Morice, M.-C., Holmes, D. R., Feldman, T. E., Dawkins, K. D., Colombo, A., Serruys, P. W., Kappetein, A. P., for the SYNTAX Investigators Tags: Molecular biology ADULT CARDIAC Source Type: research

Characteristics of statewide protocols for emergency medical services in the United States.
CONCLUSION: Statewide mandated EMS treatment protocols exist in 21 states, and optional model protocol guidelines are provided by 17 states. There is wide variation in the format and characteristics of these protocols and the recognition of specialty receiving centers for patients with time-sensitive illnesses. PMID: 25689221 [PubMed - in process]
Source: Prehospital Emergency Care - February 14, 2016 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research

Mental and Physical Health Conditions in US Combat Veterans: Results From the National Health and Resilience in Veterans Study.
Conclusions: Compared to noncombat veterans in the United States, combat veterans have elevated rates of PTSD, suicide attempt, stroke, and chronic pain independent of other sociodemographic, military, and mental health factors. Younger combat veterans have elevated rates of PTSD, suicidal ideation, and migraine headaches, while older combat veterans have elevated rates of heart disease and heart attack. These results characterize the population-based burden of mental and physical health conditions in combat veterans. They further underscore the importance of age- and condition-sensitive screening, monitoring, and treatmen...
Source: The Primary Care Companion for CNS Disorders - June 30, 2017 Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research

Review of Article: Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease. Eikelboom JW, Connolly SJ, Bosch J, et  al. for the COMPASS Investigators
Cardiovascular disease accounts for nearly 801,000 deaths in  the United States.1 Patients with vascular disease have a 20%-60% increased risk of a myocardial infarction (MI), a 40% increased risk of a stroke, and a 2- to 6-fold increase of death due to cardiovascular disease.2,3 The primary goal in antiplatelet therapy is to reduce the risk of MI, stroke, o r vascular death in patients with atherosclerosis and has been the cornerstone in medical management of the patient with cardiovascular disease.
Source: Journal of Vascular Nursing - October 24, 2017 Category: Nursing Authors: Debra Kohlman-Trigoboff Tags: Research Column Source Type: research

Effect of high-dose oral multivitamins and minerals in participants not treated with statins in the randomized Trial to Assess Chelation Therapy (TACT)
Conclusion and relevance High-dose oral multivitamin and multimineral supplementation seem to decrease combined cardiac events in a stable, post-MI population not taking statin therapy at baseline. These unexpected findings are being retested in the ongoing TACT2.
Source: American Heart Journal - November 9, 2017 Category: Cardiology Source Type: research

HIV-positive adults are under-treated for cardiovascular problems compared to those without HIV
This study provides evidence that U.S. policymakers and professional societies should focus on improving the quality of the cardiovascular care that people who are HIV-positive receive.AUTHORSStudy authors are Dr. Joseph Ladapo, Dr. Adam Richards, Cassandra DeWitt, Nina Harawa, Steven Shoptaw, Dr. William Cunningham and Dr. John Mafi, all of UCLA. Mafi is also associated with Rand Corporation.JOURNALThestudy is published in the Journal of the American Heart Association.FUNDINGGrants from the National Heart, Lung and Blood Institute, National Institute on Minority Health and Health Disparities, and National Institute of Men...
Source: UCLA Newsroom: Health Sciences - November 22, 2017 Category: Universities & Medical Training Source Type: news