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Total 106 results found since Jan 2013.

Changing the landscape of stroke in Egypt
Egypt, a low –middle-income country, is the most populated nation in the Middle East. In Egypt, the overall crude prevalence rate of stroke is high (963/100,000 inhabitants), and the incidence of stroke annually is approximately 150 000 to 210 000. The official national statistics indicate that diseases of the circulatory system, including stroke, are the primary cause of death in Egypt, where stroke accounts for 6.4% of all deaths and ranks third after cardiovascular and gastrointestinal diseases. Although the number of deaths attributed to stroke have declined in many countries, in Egypt, it was relati vely unchanged in the past 10 years.
Source: Cerebrovascular Diseases Extra - December 3, 2021 Category: Neurology Source Type: research

Alloimmunization in Egyptian Children with Sickle Cell Disease
ConclusionThe distribution of the blood group antigens in patients with SCD has important clinical significance especially those who often require regular blood transfusion and who may have developed multiple antibodies. The resultant alloimmunization is serious necessitates early recognition and management.
Source: QJM - October 1, 2021 Category: Internal Medicine Source Type: research

Evaluation of brain iron content in Egyptian Patients with Sickle cell disease and its impact on Neurocognitive functions
ConclusionThe results of our study showed that even in cases of iron overload which affects vital organs as the liver, cardiac and brain iron overload don't occur.
Source: QJM - October 1, 2021 Category: Internal Medicine Source Type: research

Electroencephalographic Findings in a Cohort of Egyptian Systemic Lupus Erythematosus Patients with Neuropsychiatric Manifestations
ConclusionNot all patients with NPSLE must have abnormal brain MRI or EEG. EEG is a useful assistant tool in diagnosing and studying the different manifestations of NPSLE especially seizure disorder and acute confusional state, but it cannot be used as a screening test alone for detecting NPSLE and must be supplemented by neuroimaging studies.
Source: QJM - October 1, 2021 Category: Internal Medicine Source Type: research

Prevalence of paroxysmal atrial fibrillation in patients with cerebrovascular stroke of undetermined etiology
ConclusionThe prevalence of paroxysmal atrial fibrillation among the population of ischemic stroke of undetermined etiology in a population in Egypt is close to worldwide percentage and the recent met analysis studies of 11%.
Source: QJM - October 1, 2021 Category: Internal Medicine Source Type: research

DWI Lesion Characteristics As A Predictor For Outcome In Acute Stroke Patients Treated By IV-tPA
ConclusionDWI infarct volume is a predictor for outcome in acute ischemic stroke patients treated by tPA
Source: QJM - October 1, 2021 Category: Internal Medicine Source Type: research

A Morphological Study of Left Atrial Appendage in Egyptian patients Using multidetector computed tomography (MDCT)
ConclusionEgyptian patients had predominantly windsock morphology in males and cactus morphology in females.
Source: QJM - October 1, 2021 Category: Internal Medicine Source Type: research

A pilot study of the ticagrelor role in ischemic stroke secondary prevention
Conclusion: Ticagrelor was noninferior to aspirin regarding safety profile. Compared with aspirin, ticagrelor had a better clinical outcome based on NIHSS and mRS in first-ever acute ischemic stroke patients who received it within 9 h from symptom onset, leading to a shorter hospital stay.Eur Neurol
Source: European Neurology - August 30, 2021 Category: Neurology Source Type: research

Safety and Efficacy of Pharmaco-invasive Approach Using Streptokinase Compared With Primary Percutaneous Coronary Angiography
Conclusion: Utilizing streptokinase in early re-perfused patients by PI approach (≤3 hrs) seems safe and efficient when PPCI delay (>120 min from symptom onset) is the other option.
Source: Critical Pathways in Cardiology - August 28, 2021 Category: Cardiology Tags: Original Study Source Type: research

Neuroprotective effect of green and roasted coffee bean extracts on cerebral ischemia-induced injury in rats
In conclusion, GCBE and RCBE represent a potential clinical strategy for pre-ischemic conditioning.
Source: Metabolic Brain Disease - July 2, 2021 Category: Neurology Source Type: research

Borderzone Infarction and Small Vessel Disease in a Sample of Egyptian Stroke Patients: Differences and Similarities
Conclusion: Limb shaking, retinal claudication or syncope, with MRI showing rosary pattern of white matter hyperintensity, few microbleeds and markedly impaired perfusion favor the diagnosis of borderzone infarctions. On the other hand, presence of lacunae, FLAIR showing symmetrical WMH and microbleeds with minimal or no perfusion deficit suggests the diagnosis of small vessel disease.
Source: Neurology India - June 24, 2021 Category: Neurology Authors: Nevine M El Nahas Hany M Aref Taha K Alloush Nagia A Fahmy Khaled A Ahmed Ahmed A El Basiouny Mohamed A Tork Ahmed M Elbokl Hossam M Shokri Source Type: research

Circulating lncRNAs HIF1A-AS2 and LINLK-A: Role and Relation to Hypoxia-Inducible Factor-1 α in Cerebral Stroke Patients
This study investigated the expression of lncRNAs HIF1A-AS2 and LINK-A, and their target gene hypoxia-inducible factor-1 (HIF-1) in Egyptian stroke patients. It also aimed to determine the molecular mechanism implicated in the disease. A total of 75 stroke patients were divided into three clinical subgroups, besides 25 healthy controls of age-matched and sex-matched. Remarkable upregulation of lncRNA HIF1A-AS2 and HIF1- α along with a downregulation of lncRNA LINK-A was noticed in all stroke groups relative to controls. Serum levels of phosphatidylinositol 3-kinase (PI3K), phosphorylated-Akt (p-Akt), vascular endothelial ...
Source: Molecular Neurobiology - June 5, 2021 Category: Neurology Source Type: research

Pre-micro RNA polymorphism detection in small versus large vessel disease in stroke Egyptian patients
AbstractStroke is the main cause of adult disability and is responsible for around 11% of deaths all over the world. Ischemic stroke encompasses about 80 –85% of total stroke cases. Several studies have shown the relation between microRNAs polymorphism and ischemic stroke. The aim of the study was to evaluate the influence of three common single nucleotide polymorphisms in pre-miRNAs (hsa-miR-146a/rs2910164, hsa-miR-196a2/rs11614913 and hsa-miR-499 /rs3746444) on individual susceptibility to the risk of ischemic stroke subtypes in Egyptian population with 117 ischemic stroke patients. Results showed that hsa-miR-146a/rs2...
Source: Metabolic Brain Disease - April 8, 2021 Category: Neurology Source Type: research

Middle East Treatment Strategies and Clinical Outcomes in Patients with Atrial Fibrillation: One-Year Follow-up Data from Garfield-AF Study
ConclusionWe have found that rates of stroke and bleeding were lower, although mortality was higher, in the Middle East population. This paper describes the baseline characteristics, patterns of antithrombotic treatment and 1-year outcomes in Middle East AF patients.Trial Registrationhttp://www.clinicaltrials.gov. Identifier, NCT01090362.
Source: Advances in Therapy - March 27, 2021 Category: Drugs & Pharmacology Source Type: research

Clinical and Radiological Characteristics of Acute Cerebrovascular Diseases Among Egyptian Patients With COVID-19 in Upper Egypt
Conclusion: Acute CVD among patients with COVID-19 was common in our study. LVO was the commonest. Hypertension, IHD, and anemia are the most common risk factors and could contribute to the worsening of clinical presentation. Comorbidities were common among patients with CVD, although a large number had elevated liver enzymes and creatinine that were partially due to COVID-19 infection itself. The current results begin to characterize the spectrum of CVD associated with COVID-19 in patients in Upper Egypt.Registration ID: The ID number of this study is IRB no: 17300470.
Source: Frontiers in Neurology - March 22, 2021 Category: Neurology Source Type: research