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Condition: Atrial Fibrillation
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Total 200 results found since Jan 2013.

Alcohol consumption and risk of cardiovascular outcomes and bleeding in patients with established atrial fibrillation
CMAJ. 2021 Jan 25;193(4):E117-E123. doi: 10.1503/cmaj.200778.ABSTRACTBACKGROUND: Little is known about the association between alcohol consumption and risk of cardiovascular events in patients with established atrial fibrillation (AF). The main aim of the current study was to investigate the associations of regular alcohol intake with incident stroke or systemic embolism in patients with established AF.METHODS: To assess the association between alcohol consumption and cardiovascular events in patients with established AF, we combined data from 2 comparable prospective cohort studies that followed 3852 patients with AF for ...
Source: Canadian Medical Association Journal - March 5, 2021 Category: General Medicine Authors: Philipp Reddiess Stefanie Aeschbacher Pascal Meyre Michael Coslovsky Michael K ühne Nicolas Rodondi Oliver Baretella J ürg H Beer Richard Kobza Giorgio Moschovitis Marcello Di Valentino Cyrill M üller Fabienne Steiner Leo H Bonati Christian Sticherling Source Type: research

Patient-reported outcomes and the identification of subgroups of atrial fibrillation patients: a retrospective cohort study of linked clinical registry and administrative data
ConclusionUsing growth mixture models, we found that not all health trajectories are the same. These models can help to understand variability in trajectories with different patient characteristics that could inform tailored interventions and patient education strategies.
Source: Quality of Life Research - February 12, 2021 Category: Health Management Source Type: research

Temporal Trends in Population Rates of Incident Atrial Fibrillation and Atrial Flutter Hospitalizations, Stroke Risk, and Mortality Show Decline in Hospitalizations
Publication date: February 2021Source: Canadian Journal of Cardiology, Volume 37, Issue 2Author(s): Roopinder K. Sandhu, Stephen B. Wilton, Sunjiduatul Islam, Clare L. Atzema, Mark Deyell, D. George Wyse, Jafna L. Cox, Allan Skanes, Padma Kaul
Source: Canadian Journal of Cardiology - January 31, 2021 Category: Cardiology Source Type: research

Association Between Sex and Treatment Outcomes of Atrial Fibrillation Ablation Versus Drug Therapy: Results from the CABANA Trial.
Conclusions: Clinically relevant treatment-related strategy differences in the primary and secondary clinical outcomes of CABANA were not seen between men and women, and there were no sex differences in adverse events. The CABANA trial results support catheter ablation as an effective treatment strategy for both women and men. Clinical Trial Registration: URL: https://clinicaltrials.gov Unique Identifier: NCT00911508. PMID: 33499668 [PubMed - as supplied by publisher]
Source: Circulation - January 27, 2021 Category: Cardiology Authors: Russo AM, Zeitler EP, Giczewska A, Silverstein AP, Al-Khalidi HR, Cha YM, Monahan KH, Bahnson TD, Mark DB, Packer DL, Poole JE, CABANA Investigators Tags: Circulation Source Type: research

Regulatory Role of Cardiomyocyte Metabolism via AMPK Activation in Modulating Atrial Structural, Contractile, and Electrical Properties Following Atrial Fibrillation.
Abstract Patients diagnosed with atrial fibrillation (AF) have been rising due to increased incidence, enhanced detection methods, and greater survival rates following diagnosis. Due to this increase, AF is now the most commonly diagnosed arrhythmia in clinical practice. AF is characterized by irregular, high-frequency contractions of atrial myocytes that lead to turbulent blood flow and the potential for thrombus formation, stroke, or heart failure. These high-frequency contractions of the atrial myocytes cause an imbalance between metabolic supply and demand. Although advances have been made in understanding the...
Source: Canadian Journal of Physiology and Pharmacology - October 13, 2020 Category: Drugs & Pharmacology Authors: Brown SM, Larsen NK, Thankam FG, Agrawal DK Tags: Can J Physiol Pharmacol Source Type: research

Costs of surgical ablation of atrial fibrillation in Ontario, Canada from 2006 to 2017
ConclusionOntario taxpayers spend significant financial resources on surgical ablation of AF, a procedure lacking high ‐quality evidence demonstrating benefit in reducing mortality or stroke. Further large prospective studies examining clinically important outcomes are needed to justify its routine use in patient care and to guide allocation of healthcare funds.
Source: Journal of Cardiac Surgery - September 27, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Justin Y. Chow, Graham McClure, Emilie P. Belley ‐Côté, William F. McIntyre, Rohit K. Singal, Richard P. Whitlock Tags: ORIGINAL ARTICLE Source Type: research

Distorting effect of immortal time bias on the association between catheter ablation for atrial fibrillation and incident stroke: Caveat Emptor
Publication date: Available online 24 September 2020Source: Canadian Journal of CardiologyAuthor(s): Michelle Samuel, James M. Brophy, Laura D’Aronco, Jean-Claude Tardif, Paul Khairy
Source: Canadian Journal of Cardiology - September 25, 2020 Category: Cardiology Source Type: research

Antiarrhythmic and cardiac electrophysiological effects of SZV-270, a novel compound with combined Class I/B and Class III effects, in rabbits and dogs.
In conclusion, SZV-270 with its combined Class I/B and III effects can prevent re-entry arrhythmias with reduced risk of provoking drug-induced Torsades de Pointes. PMID: 32970956 [PubMed - as supplied by publisher]
Source: Canadian Journal of Physiology and Pharmacology - September 23, 2020 Category: Drugs & Pharmacology Authors: Varga RS, Hornyik T, Husti Z, Kohajda Z, Krajsovszky G, Nagy N, Jost N, Virág L, Tálosi L, Mátyus P, Varró A, Baczkó I Tags: Can J Physiol Pharmacol Source Type: research

Biosense Webster Unveils Late-Breaking Results from PRECEPT Study in Patients with Persistent Atrial Fibrillation
IRVINE, CA – May 8, 2020 – Johnson & Johnson Medical Devices Companies* today announced that Biosense Webster, Inc.’s THERMOCOOL SMARTTOUCH® SF Ablation Catheter, evaluated in the PRECEPT study for the treatment of persistent atrial fibrillation (AF), resulted in freedom from any documented, symptomatic atrial arrhythmias at 15 months post-procedure for eight out of ten study participants (80.4 percent).1 Use of the THERMOCOOL SMARTTOUCH SF CATHETER for persistent atrial fibrillation is investigational only. This PRECEPT study data support a Premarket Approval supplement application to the U.S. Food and Drug Adm...
Source: Johnson and Johnson - May 12, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Temporal Trends in Population Rates of Incident Atrial Fibrillation/Atrial Flutter Hospitalizations, Stroke Risk and Mortality Show Decline in Hospitalizations
Publication date: Available online 29 April 2020Source: Canadian Journal of CardiologyAuthor(s): Roopinder K. Sandhu, Stephen B. Wilton, Sunjiduatul Islam, Clare L. Aztema, Mark Deyell, D. George Wyse, Jafna L. Cox, Allan Skanes, Padma Kaul
Source: Canadian Journal of Cardiology - April 30, 2020 Category: Cardiology Source Type: research

Incident heart failure in outpatients with chronic coronary syndrome: results from the international prospective CLARIFY registry
ConclusionA sizeable proportion of patients with chronic coronary syndrome develop HF, which only infrequently requires hospitalization. Early identification of patients with HF may lead to early treatment, and help to further decrease mortality and morbidity. This concept needs confirmation in future studies.
Source: European Journal of Heart Failure - April 14, 2020 Category: Cardiology Authors: Zofia Parma, Adam Jasilek, Nicola Greenlaw, Roberto Ferrari, Ian Ford, Kim Fox, Jean ‐Claude Tardif, Michal Tendera, P. Gabriel Steg Tags: Research Article Source Type: research

Oral Anticoagulants and Antiplatelet Agents in Atrial Fibrillation Patients with Concomitant Critical Limb Ischemia: A nationwide cohort study
ConclusionsDOAC was associated with a significantly lower risk of composite net-clinical-benefit outcome than either warfarin or APT in AF patients with concomitant CLI. Further prospective study is necessary to validate the findings in the future.
Source: Canadian Journal of Cardiology - February 19, 2020 Category: Cardiology Source Type: research

Electrical versus pharmacological cardioversion for emergency department patients with acute atrial fibrillation (RAFF2): a partial factorial randomised trial
This study is registered at ClinicalTrials.gov, number NCT01891058.FindingsBetween July 18, 2013, and Oct 17, 2018, we enrolled 396 patients, and none were lost to follow-up. In the drug–shock group (n=204), conversion to sinus rhythm occurred in 196 (96%) patients and in the shock-only group (n=192), conversion occurred in 176 (92%) patients (absolute difference 4%; 95% CI 0–9; p=0·07). The proportion of patients discharged home was 97% (n=198) versus 95% (n=183; p=0·60). 106 (52%) patients in the drug–shock group converted after drug infusion only. No patients had serious adverse events in follow-up. The differen...
Source: The Lancet - January 31, 2020 Category: General Medicine Source Type: research

Dual-Antithrombotic Therapy With DOACs After Acute Coronary Syndrome or Percutaneous Coronary Intervention in Atrial Fibrillation: A Meta-analysis of Randomized Controlled Trials
ConclusionsIn patients with AF and recent ACS or PCI, the use of dual-antithrombotic therapy with DOACs was associated with less major bleeding and less major bleeding or clinically relevant nonmajor bleeding compared with triple therapy. The use of dual therapy also showed nonsignificantly higher composite of death and ischemic events but no difference in mortality.RésuméContexteIl est difficile de choisir un traitement antithrombotique en cas de fibrillation auriculaire (FA) chez les patients ayant subi un syndrome coronarien aigu (SCA) ou une intervention coronarienne percutanée (ICP). Nous avons comparé les résult...
Source: Canadian Journal of Cardiology - December 24, 2019 Category: Cardiology Source Type: research