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New Insights into the Use of Cardiac Magnetic Resonance Imaging to Guide Decision-Making in AF Management
Publication date: Available online 12 July 2018Source: Canadian Journal of CardiologyAuthor(s): Tarek Zghaib, Saman NazarianAbstractRecent advances in cardiac magnetic resonance (CMR) imaging acquisition techniques have enabled the visualization of thin atrial myocardium with high temporal and spatial resolution and have the potential to shift atrial fibrillation (AF) management paradigms. Late gadolinium-enhancement (LGE) CMR can non-invasively identify atrial arrhythmogenic scar substrates and has been shown to spatially correlate with low-voltage areas. Immediately post-ablation, a combination of native T1-weighted, LGE...
Source: Canadian Journal of Cardiology - July 12, 2018 Category: Cardiology Source Type: research

Importance of Considering Competing Risks in Time-to-Event Analyses: Application to Stroke Risk in a Retrospective Cohort Study of Elderly Patients With Atrial Fibrillation Original Articles
Conclusions: The incidence of death without stroke was 9-fold higher than that of stroke, leading to biased estimates of stroke risk with traditional time-to-event methods. Statistical methods that appropriately account for competing risks should be used to mitigate this bias.
Source: Circulation: Cardiovascular Quality and Outcomes - July 11, 2018 Category: Cardiology Authors: Abdel-Qadir, H., Fang, J., Lee, D. S., Tu, J. V., Amir, E., Austin, P. C., Anderson, G. M. Tags: Atrial Fibrillation, Epidemiology, Primary Prevention, Cerebrovascular Disease/Stroke Original Articles Source Type: research

Reply to Kea et al.—Stroke Prevention for High-Risk Atrial Fibrillation in the Emergency Setting: Differences Between Canada and the US
Publication date: July 2018Source: Canadian Journal of Cardiology, Volume 34, Issue 7Author(s): Clare L. Atzema
Source: Canadian Journal of Cardiology - July 10, 2018 Category: Cardiology Source Type: research

Stroke Prevention for High-Risk Atrial Fibrillation in the Emergency Setting: Differences Between Canada and the United States
Publication date: July 2018Source: Canadian Journal of Cardiology, Volume 34, Issue 7Author(s): Bory Kea, Benjamin C. Sun, David R. Vinson
Source: Canadian Journal of Cardiology - July 10, 2018 Category: Cardiology Source Type: research

Response to Letter to the Editor re “Elevated Incidence of Atrial Fibrillation and Stroke in Patients with Atrial Flutter – A Population-Based Study”
Publication date: Available online 15 June 2018Source: Canadian Journal of CardiologyAuthor(s): Lorne J. Gula, Damian P. Redfearn, Krista B. Jenkyn, Britney Allen, Allan C. Skanes, Peter Leong-Sit, Salimah Z. Shariff
Source: Canadian Journal of Cardiology - July 10, 2018 Category: Cardiology Source Type: research

Establishing Therapeutic Equivalence of Complex Pharmaceuticals: The Case of Dabigatran
Publication date: Available online 5 June 2018Source: Canadian Journal of CardiologyAuthor(s): Jeffrey Weitz, Karen M. Earl, Kori Leblanc, William Semchuk, Fakhreddin JamaliAbstractDabigatran is widely used for stroke prevention in atrial fibrillation. Dabigatran is no longer patent protected in Canada and 2 generic formulations were recently approved by Health Canada. Branded dabigatran utilizes a complex formulation to maintain the acidic microenvironment required for maximal absorption. Consequently, food does not influence its bioavailability and the efficacy and safety of dabigatran are similar with or without concomi...
Source: Canadian Journal of Cardiology - July 10, 2018 Category: Cardiology Source Type: research

Incident Atrial Fibrillation and Stroke in Patients With Atrial Flutter
Publication date: June 2018Source: Canadian Journal of Cardiology, Volume 34, Issue 6Author(s): Jorge A. Wong, Jeff S. Healey
Source: Canadian Journal of Cardiology - July 10, 2018 Category: Cardiology Source Type: research

Factors Influencing Oral Anticoagulation Prescription for Patients Presenting to Emergency Departments With Atrial Fibrillation and Flutter
Publication date: June 2018Source: Canadian Journal of Cardiology, Volume 34, Issue 6Author(s): Robert J.H. Miller, Derek S. Chew, Saman Rezazadeh, Sheila Klassen, Payam Pournazari, Eddy Lang, F. Russell QuinnAbstractAtrial fibrillation and atrial flutter (AF/AFL) are associated with an increased risk of stroke and systemic embolism. However, many patients are not started on guideline-recommended oral anticoagulation (OAC). We determined factors associated with initiation of OAC in eligible patients presenting to emergency departments. This retrospective cohort included patients with electrocardiogram (ECG)-documented AF/A...
Source: Canadian Journal of Cardiology - July 10, 2018 Category: Cardiology Source Type: research

Elevated Incidence of Atrial Fibrillation and Stroke in Patients With Atrial Flutter—A Population-Based Study
ConclusionsPatients with isolated atrial flutter develop AF and stroke at a higher rate than the general population. Catheter ablation reduces but does not eliminate future AF incidence and stroke risk and continued anticoagulation after successful atrial flutter ablation might therefore be warranted.RésuméIntroductionOn ignore le risque d’accident vasculaire cérébral (AVC) dû au flutter auriculaire et sa relation avec la progression de la fibrillation auriculaire (FA). La présente étude décrit l’incidence de la FA et de l'AVC chez les patients atteints de flutter auriculaire, et montre si l’ablation du flutt...
Source: Canadian Journal of Cardiology - July 10, 2018 Category: Cardiology Source Type: research

A clinical decision instrument to predict 30-day death & cardiovascular hospitalizations following an emergency department visit for atrial fibrillation: The atrial fibrillation in the emergency room, part 2 (AFTER2) study
ConclusionsUsing a population-based sample, we derived and validated a tool that predicts the risk of early death and re-hospitalization for a cardiovascular reason in emergency department AF patients. The tool can offer information to managing physicians about the risk of death and re-hospitalization AF patients seen in the in emergency department, as well as identify patient groups for future targeted interventions aimed at preventing these outcomes.Graphical AbstractThe Atrial Fibrillation in the Emergency Room, part 2 (AFTER2) Study
Source: American Heart Journal - July 10, 2018 Category: Cardiology Source Type: research

Reply to Kea et al.—Stroke Prevention for High-Risk Atrial Fibrillation in the Emergency Setting: Differences Between Canada and the US
Publication date: July 2018Source: Canadian Journal of Cardiology, Volume 34, Issue 7Author(s): Clare L. Atzema
Source: Canadian Journal of Cardiology - July 5, 2018 Category: Cardiology Source Type: research

Stroke Prevention for High-Risk Atrial Fibrillation in the Emergency Setting: Differences Between Canada and the United States
Publication date: July 2018Source: Canadian Journal of Cardiology, Volume 34, Issue 7Author(s): Bory Kea, Benjamin C. Sun, David R. Vinson
Source: Canadian Journal of Cardiology - July 5, 2018 Category: Cardiology Source Type: research

Response to Letter to the Editor re “Elevated Incidence of Atrial Fibrillation and Stroke in Patients with Atrial Flutter – A Population-Based Study”
Publication date: Available online 15 June 2018Source: Canadian Journal of CardiologyAuthor(s): Lorne J. Gula, Damian P. Redfearn, Krista B. Jenkyn, Britney Allen, Allan C. Skanes, Peter Leong-Sit, Salimah Z. Shariff
Source: Canadian Journal of Cardiology - July 5, 2018 Category: Cardiology Source Type: research

Establishing Therapeutic Equivalence of Complex Pharmaceuticals: The Case of Dabigatran
Publication date: Available online 5 June 2018Source: Canadian Journal of CardiologyAuthor(s): Jeffrey Weitz, Karen M. Earl, Kori Leblanc, William Semchuk, Fakhreddin JamaliAbstractDabigatran is widely used for stroke prevention in atrial fibrillation. Dabigatran is no longer patent protected in Canada and 2 generic formulations were recently approved by Health Canada. Branded dabigatran utilizes a complex formulation to maintain the acidic microenvironment required for maximal absorption. Consequently, food does not influence its bioavailability and the efficacy and safety of dabigatran are similar with or without concomi...
Source: Canadian Journal of Cardiology - July 5, 2018 Category: Cardiology Source Type: research

Incident Atrial Fibrillation and Stroke in Patients With Atrial Flutter
Publication date: June 2018Source: Canadian Journal of Cardiology, Volume 34, Issue 6Author(s): Jorge A. Wong, Jeff S. Healey
Source: Canadian Journal of Cardiology - July 5, 2018 Category: Cardiology Source Type: research

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