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Condition: Ischemic Stroke
Countries: Australia Health

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Total 193 results found since Jan 2013.

Cost-effectiveness of mechanical thrombectomy for acute ischemic stroke: an Australian payer perspective.
CONCLUSIONS: Mechanical thrombectomy is a cost-effective treatment option for AIS, with clinical benefits translating to short and long-term cost benefits. This analysis supports rapid update of stroke care pathways to incorporate this therapy as a treatment option. PMID: 29741126 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - May 11, 2018 Category: Health Management Tags: J Med Econ Source Type: research

Tenecteplase versus alteplase in acute ischemic stroke: systematic review and meta-analysis
AbstractTenecteplase is a product of genetic modification of recombinant tissue plasminogen activator with superior pharmacodynamic and pharmacokinetic properties. This meta-analysis was to determine whether intravenous thrombolysis with tenecteplase in patients with acute ischemic stroke has better efficacy and safety outcomes than with intravenous alteplase. PubMed, Cochrane Central Register of Controlled Trials, WHO International clinical trials registry platform (ICTRP), Australian New Zealand Clinical Trials Registry (ANZCTR), EU Clinical Trials Register (EU-CTR) and ClinicalTrials.gov were searched for trials compari...
Source: Acta Neurologica Belgica - May 4, 2018 Category: Neurology Source Type: research

Modafinil for the Improvement of Patient Outcomes Following Traumatic Brain Injury
Conclusion. Modafinil is a central nervous system stimulant with well-established effectiveness in the treatment of narcolepsy and shift-work sleep disorder. There is conflicting evidence about the benefits of modafinil in the treatment of fatigue and EDS secondary to TBI. One randomized, controlled study states that modafinil does not significantly improve patient wakefulness, while another concludes that modafinil corrects EDS but not fatigue. An observational study provides evidence that modafinil increases alertness in fatigued patients with past medical history of brainstem diencephalic stroke or multiple sclerosis. ...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Review excessive daytime sleep fatigue head injury modafinil stroke TBI traumatic brain injury Source Type: research

EBR Systems launches trial for wireless pacer
EBR Systems said yesterday that it launched a 350-patient investigational device exemption trial of its Wise wireless pacemaker it hopes to use to win FDA approval. Sunnyvale, Calif.-based EBR’s device uses a subcutaneous generator to wirelessly deliver ultrasound energy to a “pellet” implanted in the right ventricle, which it uses to synchronize the left and right ventricles. The system is designed to eliminate the need for a left ventricular lead by allowing the operating physician to place the stimulation “pellet” in a patient-specific location inside the left ventricle. The FDA approved the Solve-CRT stu...
Source: Mass Device - March 8, 2018 Category: Medical Devices Authors: Brad Perriello Tags: Cardiovascular Clinical Trials Cardiac Rhythm Management EBR Systems Inc. Source Type: news

Quality of Life Is Poorer for Patients With Stroke Who Require an Interpreter Brief Report
Background and Purpose—In multicultural Australia, some patients with stroke cannot fully understand, or speak, English. Language barriers may reduce quality of care and consequent outcomes after stroke, yet little has been reported empirically.Methods—An observational study of patients with stroke or transient ischemic attack (2010–2015) captured from 45 hospitals participating in the Australian Stroke Clinical Registry. The use of interpreters in hospitals, which is routinely documented, was used as a proxy for severe language barriers. Health-Related Quality of Life was assessed using the EuroQoL-5 dimension-3 lev...
Source: Stroke - February 26, 2018 Category: Neurology Authors: Monique F. Kilkenny, Natasha A. Lannin, Craig S. Anderson, Helen M. Dewey, Joosup Kim, Karen Barclay-Moss, Chris Levi, Steven Faux, Kelvin Hill, Brenda Grabsch, Sandy Middleton, Amanda G. Thrift, Rohan Grimley, Geoffrey Donnan, Dominique A. Cadilhac Tags: Race and Ethnicity, Mortality/Survival, Quality and Outcomes, Ischemic Stroke, Transient Ischemic Attack (TIA) Brief Reports Source Type: research

What Causes Microcephaly?
Discussion Microcephaly is usually defined as an occipitofrontal head circumference (OFC) more than 2 standard deviations (SD) below the mean for sex, age and ethnicity. Severe microcephaly is used for OFC < 3 standard deviations. Rates of microcephaly range from 0.5-12 patients/10,000 live births. The OFC should be measured at every well child visit and at other opportunities and plotted on standard growth charts. The OFC is measured using a nonelastic tape measure around the largest part of the head with the tape measure held above the eyebrows and ears. It is a highly reproducible measurement. There are several diff...
Source: PediatricEducation.org - September 25, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Reflection on Stroke Deaths and end ‐of‐life stroke care
ConclusionIn this cohort, palliative care referral and EOLCP were commenced in less than 50% of patients, highlighting significant variations in clinical care. These data support the need to promote awareness of ACP, particularly in patients with prior stroke or significant co‐morbidities. This may help reduce potentially futile invasive investigations and treatment.
Source: Internal Medicine Journal - September 11, 2017 Category: Internal Medicine Authors: Syed Zujajuddin Quadri, Thang Huynh, Cecilia Cappelen ‐Smith, Nirupama Wijesuriya, Abul Mamun, Roy Beran, Alan Mcdougall, Dennis Cordato Tags: Original Article Source Type: research

Focal Cerebral Arteriopathy Clinical Sciences
Conclusions—Corticosteroid treatment may provide additional benefit over AT for improved neurological outcome in childhood AIS because of focal cerebral arteriopathy. Larger prospective studies are warranted to further investigate these differences and understand mechanisms by which steroids modify outcome.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Maȷa Steinlin, Sandra Bigi, Belinda Stoȷanovski, Jay Gaȷera, Maria Regenyi, Marwan El–Koussy, Mark T. Mackay Tags: Ischemic Stroke Original Contributions Source Type: research

Community-Based Intervention to Improve Cardiometabolic Targets in Patients With Stroke Clinical Sciences
Conclusions—The intervention in this largely negative trial only had a detectable effect on attaining target for lipids but not for other factors at 12 months or any factor at 24 months. This limited effect may be attributable to inadequate uptake of behavioral/lifestyle interventions, highlighting the need for new or better approaches to achieve meaningful behavioral change.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: ACTRN12608000166370.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Muideen T. Olaiya, Dominique A. Cadilhac, Joosup Kim, Mark R. Nelson, Velandai K. Srikanth, Richard P. Gerraty, Christopher F. Bladin, Sharyn M. Fitzgerald, Thanh Phan, Judith Frayne, Amanda G. Thrift Tags: Lifestyle, Risk Factors, Secondary Prevention, Treatment, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Benefits of clinical facilitators on improving stroke care in acute hospitals: a new programme for Australia
ConclusionFixed‐term employment of Facilitators was effective in positively influencing stroke care in hospitals through a range of change management strategies where stroke‐specific expertise had been previously limited.
Source: Internal Medicine Journal - July 4, 2017 Category: Internal Medicine Authors: Tara Purvis, Karen Moss, Linda Francis, Karen Borschmann, Monique F. Kilkenny, Sonia Denisenko, Christopher F. Bladin, Dominique A. Cadilhac Tags: Original Article Source Type: research

Association of Vegetable Nitrate Intake With Carotid Atherosclerosis and Ischemic Cerebrovascular Disease in Older Women Clinical Sciences
Conclusions—Independent of other risk factors, higher vegetable nitrate was associated with a lower CCA-IMT and a lower risk of an ischemic cerebrovascular disease event.
Source: Stroke - June 26, 2017 Category: Neurology Authors: Catherine P. Bondonno, Lauren C. Blekkenhorst, Richard L. Prince, Kerry L. Ivey, Joshua R. Lewis, Amanda Devine, Richard J. Woodman, Jon O. Lundberg, Kevin D. Croft, Peter L. Thompson, Jonathan M. Hodgson Tags: Diet and Nutrition, Epidemiology, Cerebrovascular Disease/Stroke, Vascular Disease Original Contributions Source Type: research

Risk-adjusted hospital mortality rates for stroke: evidence from the Australian Stroke Clinical Registry (AuSCR).
CONCLUSIONS: Hospital stroke mortality rates and hospital performance ranking may vary widely according to the covariates included in the statistical analysis. PMID: 28446116 [PubMed - in process]
Source: Medical Journal of Australia - April 29, 2017 Category: Journals (General) Tags: Med J Aust Source Type: research

Thrombolysis in acute stroke: ongoing challenges based on a tertiary hospital audit and comparisons with other Australian studies.
Conclusion The proportion of eligible stroke patients who receive tPA in a timely manner remains less than ideal at our centre. More accurate patient selection and reductions in treatment delays serve as targets for quality improvement efforts that have broad applicability.What is known about the topic? Stroke unit care and tPA thrombolysis are two proven strategies to improve outcome in patients with ischaemic stroke. Although the stroke unit is gaining momentum of growth in Australia (especially in Queensland), little improvement has been achieved in thrombolysis rate and timeliness of treatment delivery, and little is k...
Source: Australian Health Review - June 29, 2015 Category: Hospital Management Authors: Lau AH, Hall G, Scott IA, Williams M Tags: Aust Health Rev Source Type: research