What Causes Microcephaly?

Patient Presentation A 5-month-old male came to clinic for his health supervision visit and followup from his neonatal intensive care stay. He was born prematurely at 28 weeks gestation and his stay was complicated by a right sided Grade III intraventricular hemorrhage, a left-sided Grade IV intraventricular hemorrhage, neonatal seizures, respiratory distress and bronchopulmonary dysplasia, retinopathy of prematurity, acute kidney injury that had resolved, possible necrotizing enterocolitis incidents x 2, and herpes simplex encephalitis. He was on home oxygen, a nasogastric feeding tube because of aspiration risk and multiple medications. He was taken care of by his mother, maternal grandmother and home nursing. He was to start home physical therapy, and had multiple followup appointments for specialty care already arranged. The pertinent physical exam showed a small infant with a nasal canula and feeding tube in place. Weight (= 4.116 kg) and height (=54 cm) were at the 3th percentile and tracking. Head circumference was
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news

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Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB01023A, PaperMarina D Childs, Lihai Yu, Michael Kovacs, Leonard G Luyt The growth hormone secretagogue receptor 1a (GHSR) is differentially expressed in various disease states compared to healthy tissues and thus is a target for molecular imaging. The endogenous ligand for... The content of this RSS Feed (c) The Royal Society of Chemistry
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We report a ligand-free copper-catalyzed α-borylation, defluorination of β-substituted, α-trifluoromethyl-α,β-unsaturated esters. The reaction affords geminal-difluoroallyl boronic acid derivatives in moderate to good yield. The reaction was tolerant of various substrates... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
Org. Biomol. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1OB01592C, CommunicationWen-Zhu Bi, Wen-Jie Zhang, Zi-Jie Li, Yuan-Hao He, Suxiang Feng, Yang Geng, Xiaolan Chen, Lingbo Qu A general visible-light-promoted metal-free synthesis of secondary and tertiary thiocarbamates starting from thiosulfonates andN-substituted formamides is developed. By employing rhodamine B as photocatalyst andtert-butyl hydroperoxide (TBHP) as oxidant,... The content of this RSS Feed (c) The Royal Society of Chemistry
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Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D1OB01599K, CommunicationRui-Li Wang, Shi-Kun Jia, Ya-Jun Guo, Yang Yi, Yuan-Zhao Hua, Hui-Jie Lu, Min-Can Wang Highly enantioselective formal [3 + 2] cycloadditionvia a Br ønsted base and Lewis acid cooperative activation model. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D1OB01654G, CommunicationWan Lei, Yongjun Liu, Yewen Fang, Yan Li, Chan Du, Jianghua Fang New access to allenes: With photocatalytic reductive radical-polar crossover as the strategy, a new protocol for the preparation of trisubstituted allenes has been nicely developedvia the reactions of 1,3-enynes with various alkyl radicals. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D1OB01256H, PaperYu Wang, Cheng Niu, Dong-Hua Xie, Da-Ming Du An effective strategy for the stereoselective synthesis of spiro isoxazolone-cyclohexenimines was developedvia a squaramide-catalysed vinylogous Michael addition/cyclization cascade reaction of 4-unsaturated isoxazol-5-ones and α,α-dicyanoalkenes. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D1OB01151K, PaperDebashruti Bandyopadhyay, Annaram Thirupathi, Divya Radhakrishnan, Adyasha Panigrahi, S. Peruncheralathan Highly functionalized 4-aminoquinolines are synthesised through a TfOH-mediated chemoselective N-heteroannulation process. In addition, a double N-heteroannulation strategy is demonstrated to synthesise indolo[3,2-c]quinolines from acyclic precursors. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
Org. Biomol. Chem., 2021, Advance Article DOI: 10.1039/D1OB01409A, PaperYuqi Zhang, Xiaojing Ye, Sicheng Liu, Wei Chen, Irfan Majeed, Tingting Liu, Yulin Zhu, Zhuo Zeng The multipurpose transition metal-free cleavage using NaOTs catalyzed various cross-coupling is reported. NaOTs demonstrated efficient C –N bond cleavage to construct new C–N, C–S, C–O, C–C bond products. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
J. Mater. Chem. A, 2021, Accepted Manuscript DOI: 10.1039/D1TA06514A, PaperJianguo Sun, Xuliang Zhang, Xufeng Ling, Yingguo Yang, Yao Wang, Junjun Guo, Shengzhong Liu, Jianyu Yuan, Wanli Ma Organic-inorganic hybrid lead halide perovskite solar cells (PSCs) attracted tremendous interest due to their excellent photovoltaic performance, while they still suffer from the poor long-term stability. Here, a penetrated 2D/3D... The content of this RSS Feed (c) The Royal Society of Chemistry
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