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Condition: Ataxia

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Total 492 results found since Jan 2013.

Isolated cerebellar-type hemiataxia in a thalamic infarction
Dejerine–Roussy syndrome presenting with hemiataxia due to loss of proprioception is a classic symptom of a thalamic stroke. In contrast, it has been reported that cerebellar ataxia, which was not directly related to the loss of proprioception, might occur due to a thalamic lesion. Recent studies using modern imaging demonstrated that a cerebellar-type hemiataxia may occur in a thalamic infarction, and the ventral lateral (VL) nucleus, the destination of the dentato-rubro-thalamic tract, has been postulated as the responsible lesion [2,7,10].
Source: Journal of the Neurological Sciences - November 27, 2015 Category: Neurology Authors: Keiichi Hokkoku, Kiyoshi Matsukura, Junpei Yamamoto, Midori Kuwabara, Takashi Chiba, Yuki Hatanaka, Masahiro Sonoo Tags: Letter to the Editor Source Type: research

Deep brain stimulation of the dentate nucleus improves cerebellar ataxia after cerebellar stroke
The cerebrocerebellum receives input from the cerebral cortex and projects to the motor and premotor cortices and the ventrolateral nucleus of the thalamus via the dentate nucleus (DN). Dentothalamocortical projections modulate the activity of the contralateral primary motor (M1) cortex and are involved in movement planning. Acute ischemic injury of the cerebellar nuclei leads to ataxia and a loss of physiologic excitatory inputs from the DN to the contralateral M1 cortex.1 However, chronic cerebellar ischemic lesions have been associated with a reemerging decrease in intracortical inhibition (ICI) in the contralesional M1...
Source: Neurology - December 7, 2015 Category: Neurology Authors: Teixeira, M. J., Cury, R. G., Galhardoni, R., Barboza, V. R., Brunoni, A. R., Alho, E., Lepski, G., Ciampi de Andrade, D. Tags: CLINICAL/SCIENTIFIC NOTES Source Type: research

Infectious Mononucleosis Complicated with Acute Cerebral Infarction: A Case Report.
CONCLUSION: Although IM is known to be self-limited, it could contribute to acute cerebral infarction, which is a rare IM neurological complication. PMID: 26179687 [PubMed - in process]
Source: Acta Neurologica Taiwanica - December 12, 2015 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Sjogren's syndrome with acute cerebellar ataxia and massive lymphadenopathy : a case report.
DISCUSSION: For patients with acute acquired cerebellar ataxia, immune-mediated cerebellar ataxia should be an important differential diagnosis aside from the more common causes like stroke or drugs. PMID: 24030041 [PubMed - indexed for MEDLINE]
Source: Acta Neurologica Taiwanica - December 12, 2015 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Paraneoplastic Neurological Syndrome in Fallopian Tube Cancer.
We report on a rare case of paraneoplastic syndrome (PS) that was discovered on completion of diagnostic work-up to be an undifferentiated fallopian tube carcinoma. A 49-year-old Caucasian woman was admitted to neurology with vertigo, gait ataxia and dysarthria, transient ischaemic attack (TIA) and stroke were quickly excluded. Indicative for the further diagnosis of a paraneoplastic syndrome was the identification of onconeuronal antibodies the detection of which can be associated with certain tumour entities. The strongly positive anti-Yo antibody that is formed above all by breast and lung cancers as well as ovarian can...
Source: Geburtshilfe und Frauenheilkunde - December 12, 2015 Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research

Puerperal Extracranial Vertebral Artery Dissection and Nonaneurysmal Subarachnoid Hemorrhage
Previously reported only a few times before, we present a case of extracranial vertebral dissection and spontaneous frontoparietal subarachnoid hemorrhage (SAH) in the puerperium, discussing possible mechanisms and difficulties in management. A 35-year-old woman presented 10 days postcaesarean section with neck pain and vertigo with normal initial investigations. Following recurrent vertigo, headache, and ataxia, imaging revealed a frontoparietal SAH and vertebral artery dissection. The patient was consequently treated with aspirin, and then following a return of symptoms 3 weeks later, warfarin therapy was continued for 6 months.
Source: Journal of Stroke and Cerebrovascular Diseases - December 14, 2015 Category: Neurology Authors: James W. Garrard, Renata F. Simm, Edson Bor-Seng-Shu, Ricardo C. Nogueira Tags: Case Studies Source Type: research

Unusual clinical cases that mimic acute disseminated encephalomyelitis.
We report on six cases of different etiologies that mimicked the clinical and radiologic findings of ADEM. The cases were collected from four different reference hospitals in Turkey. The same radiologist from the Akdeniz University Faculty of Medicine examined the magnetic resonance images of all patients. Three (50%) patients had antecedent infections. Initial symptoms of the patients were as follows: fever in 50%, altered consciousness in 33.3% and convulsions in 16.7% of patients. Neurologic examination showed long tract signs in 83.3%, ataxia in 50% and altered consciousness in 50% of patients. Cerebrospinal fluid exam...
Source: Acta Clinica Croatica - December 19, 2015 Category: Journals (General) Tags: Acta Clin Croat Source Type: research

Repeated early thrombolysis in cervical spinal cord ischemia
We report the first case of an MRI-verified cervical spinal ischemia treated by thrombolysis and review the literature. A 72-year old woman with right-sided motor hemiparesis and trunk ataxia was treated by intravenous thrombolysis with full recovery. Three days later she developed again a severe right-sided sensorimotor hemiparesis and a second off-label intravenous thrombolysis was repeated. Magnetic resonance imaging revealed a right-sided posterior-lateral cervical spinal ischemia. Spinal ischemia may clinically present with a cerebral-stroke-like picture challenging diagnostic and therapeutic procedure. Systemic throm...
Source: Journal of Thrombosis and Thrombolysis - January 13, 2016 Category: Hematology Source Type: research

Regulation of Gait and Balance: The Underappreciated Role of Neuronal Nicotinic Receptor Agonists.
Abstract Alterations in gait and balance are manifest in numerous neurological disorders such as the ataxias and Parkinson's disease, and may occur as a consequence of stroke, traumatic brain injury and chemical insults to the brain. Although the underlying etiology of these disorders differs, disturbances in gait and balance appear to reflect deficits in cholinergic pathways within the brain. During the past 40 years, both clinical case studies and preclinical data have provided evidence that nicotinic cholinergic activation is beneficial for alleviating gait and balance deficits in many disorders. Further, studi...
Source: Current Pharmaceutical Design - January 26, 2016 Category: Drugs & Pharmacology Authors: Young MF, Wecker L Tags: Curr Pharm Des Source Type: research

A case of the cerebellar cognitive affective syndrome in a 12-year-old boy with acute post-infectious cerebellar ataxia.
CONCLUSION: CCAS may be an overlooked complication to APCA. In addition, APCA is considered a transient, monophasic disease and studying CCAS in this disease may give insight into subtle cases of CCAS and thus provide new knowledge about CCAS. PMID: 26818156 [PubMed - as supplied by publisher]
Source: European Journal of Paediatric Neurology - January 12, 2016 Category: Neurology Authors: Lindberg Bonne N, Evald L, Hansen JK Tags: Eur J Paediatr Neurol Source Type: research

Mild Sedation Exacerbates or Unmasks Focal Neurologic Dysfunction in Neurosurgical Patients with Supratentorial Brain Mass Lesions in a Drug-specific Manner
Conclusions Midazolam and propofol augmented or revealed neurologic dysfunction more frequently than fentanyl and dexmedetomidine at equivalent sedation levels. Patients with high-grade gliomas were more susceptible than those with low-grade gliomas.
Source: Anesthesiology - February 17, 2016 Category: Anesthesiology Source Type: research

Teaching Video NeuroImages: Alternating skew deviation with abducting hypertropia following superior colliculus infarction
A 63-year-old patient was admitted with acute ataxia and binocular oblique diplopia. Neuro-ophthalmologic examination revealed abducting hypertropia on lateral gaze, better seen during upgaze, mimicking bilateral inferior oblique palsy (video, figure). There was no ocular cyclotorsion. Brain MRI revealed focal ischemic lesions in the right cerebellar hemisphere and left superior colliculus (figure). The diagnosis of alternating abducting hypertropic skew deviation was made. This rare type of skew deviation is related to central otolithic dysfunction. Similar cases have been described with cerebellar, pretectal, or cervico-...
Source: Neurology - February 29, 2016 Category: Neurology Authors: Biotti, D., Barbieux, M., Brassat, D. Tags: MRI, Clinical neurology examination, Ocular motility, Diplopia (double vision), All Cerebrovascular disease/Stroke RESIDENT AND FELLOW SECTION Source Type: research

Dural Arteriovenous Fistula, Medullary Edema, and Ondines Curse: A Case Report (P3.195)
Conclusions: New onset respiratory failure due to dysfunction in the CNS, called acquired central alveolar hypoventilation, has been seen in several common conditions that may affect the medulla, including demyelinating lesions and stroke. We report the first case of acquired central alveolar hypoventilation due to dAVF, where apnea during sleep (was the patient’s only residual neurologic deficit after treatment, the so-called Ondine’s curse. Clinicians evaluating hypercapnic respiratory failure should consider brainstem pathology that may impair central respiratory function and consider a dedicated angiography...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Culler, G., Afshari, M., Maas, M. Tags: Neurocritical Care: Clinical Science Source Type: research

The Role of Staufen1 in Aberrant RNA Metabolism in SCA2 (P6.396)
Conclusions: Our results unravel a novel function for Staufen1 in aberrant RNA processing events and indicate its role in SCA2 pathogenesis. Our results further support a role for aberrant RNA metabolism in neurodegeneration thereby revealing its potential as a therapeutic target. Study Supported by: This work was supported by Grants RO1NS33123 and RC4NS073009 from the National Institutes of Neurological Disorders and Stroke to SMP.Disclosure: Dr. Paul has nothing to disclose. Dr. Dansithong has nothing to disclose. Dr. Figueroa has nothing to disclose. Dr. Scoles has nothing to disclose. Dr. Pulst has received personal co...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Paul, S., Dansithong, W., Figueroa, K., Scoles, D., Pulst, S. Tags: Movement Disorders: Spinocerebellar Ataxias Source Type: research

A retrospective analysis of triptan and dhe use for basilar and hemiplegic migraine
ConclusionIn this retrospective study, triptans and DHE were used with no reported, subsequent acute/subacute ischemic vascular events for the abortive treatment of migraines with basilar and hemiplegic‐type features. Although the small sample sizes generated theoretical statistical event rates of 4.5% for BM and 23% for HM, there has been no clear evidence that BM and HM carry an actual elevated risk for vascular events compared with migraine with aura.
Source: Headache: The Journal of Head and Face Pain - February 29, 2016 Category: Neurology Authors: Paul G. Mathew, Regina Krel, Bhuvin Buddhdev, Hossein Ansari, Shivang G. Joshi, Warren D. Spinner, Brad C. Klein Tags: Research Submissions Source Type: research