The Role of Staufen1 in Aberrant RNA Metabolism in SCA2 (P6.396)

Conclusions: Our results unravel a novel function for Staufen1 in aberrant RNA processing events and indicate its role in SCA2 pathogenesis. Our results further support a role for aberrant RNA metabolism in neurodegeneration thereby revealing its potential as a therapeutic target. Study Supported by: This work was supported by Grants RO1NS33123 and RC4NS073009 from the National Institutes of Neurological Disorders and Stroke to SMP.Disclosure: Dr. Paul has nothing to disclose. Dr. Dansithong has nothing to disclose. Dr. Figueroa has nothing to disclose. Dr. Scoles has nothing to disclose. Dr. Pulst has received personal compensation for activities with Ataxion Therapeutics and Roche Pharmaceuticals as a consultant. Dr. Pulst has received personal compensation in an editorial capacity for AAN Neurology: Genetics. Dr. Pulst has received (roy
Source: Neurology - Category: Neurology Authors: Tags: Movement Disorders: Spinocerebellar Ataxias Source Type: research