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Condition: Ataxia

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Total 492 results found since Jan 2013.

Neurologic Manifestations of Coronavirus Disease 2019 in Children: An Iranian Hospital-Based Study
CONCLUSION: During the current pandemic outbreak, hospitalized children with COVID-19 should be evaluated for neurological signs because it is common among them and should not be under-estimated.PMID:37543939 | DOI:10.34172/aim.2023.25
Source: Archives of Iranian Medicine - August 6, 2023 Category: Middle East Health Authors: Elmira Haji Esmaeil Memar Morteza Heidari Homa Ghabeli Elham Pourbakhtyaran Roya Haghighi Seyyed Mohammad Mahdi Hosseiny Setareh Mamishi Shima Mahmoudi Hamid Eshaghi Ali Reza Tavasoli Mahmoud Mohammadi Reza Shervin Badv Gholamreza Zamani Masood Ghahvehchi Source Type: research

The epidemiology of intermittent and chronic ataxia in children in Manitoba, Canada
AimTo determine the epidemiology of chronic ataxia in children in Manitoba, Canada. MethodA retrospective study using multiple sources and disease codes identified children (age 0–16y) with chronic ataxia (>2mo duration or recurrent episodes of ataxia) seen at Winnipeg Children's Hospital from 1991 to 2008. Patients with isolated peripheral nerve diseases, vestibular disorders, or brain tumors were excluded. ResultsWe identified 184 patients (males=females; mean age 15y, SD 7y 8mo) with chronic ataxia. Median age at the presenting symptom onset was 1 year 3 months and at ataxia onset 3 years 1 month. Median durati...
Source: Developmental Medicine and Child Neurology - February 7, 2013 Category: Child Development Authors: Michael S Salman, Esther J Lee, Anindita Tjahjadi, Bernard N Chodirker Tags: Original Article Source Type: research

Clinical Spectrum and Course in Individuals with Intravascular Large B-Cell Lymphoma Affecting the Nervous System: A Case Series (P01.102)
CONCLUSIONS: Although IVLBL has distinct pathological features, its clinical presentation can be protean, ranging from mild myopathy to fulminant brain or multi-organ failure. The patient's optimal chance for survival relies on early pathological diagnosis and prompt, aggressive chemotherapy.Disclosure: Dr. Zhong has nothing to disclose. Dr. Oakes has nothing to disclose. Dr. Sonnen has nothing to disclose. Dr. Ransom has nothing to disclose. Dr. Longstreth has nothing to disclose. Dr. Mrugala has received personal compensation for activities with UCB Pharma, Sigma-Tau Pharmaceuticals, and Perceptive Informatics. Dr. Mruga...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Zhong, N., Oakes, P., Sonnen, J., Ransom, B., Longstreth, W. T., Mrugala, M. Tags: P01 Neuro-Oncology: Therapeutics Source Type: research

Clinical Study of Medial Area Infarction in the Region of Posterior Inferior Cerebellar Artery
Our objective is to study the neurological characteristics of medial area infarction in the caudal cerebellum. Medial area of the caudal cerebellum is supplied with 2 branches of the posterior inferior cerebellar artery (PICA). The medial hemispheric branch of the PICA distributes to the medial area of the caudal cerebellar hemisphere. The medial branch of the PICA (mPICA) distributes to the inferior vermis. We studied the neurological characteristics of 18 patients with medial area infarction of the caudal cerebellum. The infarction was located in the medial area of the cerebellar hemisphere and vermis (medial ch/vermis) ...
Source: Journal of Stroke and Cerebrovascular Diseases - March 15, 2013 Category: Neurology Authors: Katsuhiko Ogawa, Yutaka Suzuki, Minoru Oishi, Satoshi Kamei, Shuntaro Shigihara, Yasuyuki Nomura Tags: Original Articles Source Type: research

Complete resolution of a solitary pontine abscess in a patient with dental caries
A solitary brainstem abscess is a rare fatal intracranial infection, which can be mistaken for an acute stroke complicated with a systemic infection. Dental caries without abscess formation can be a possible source of infection. Herein, we describe the case of a 59-year-old man with dental caries who presented with a 4-day history of progressive dizziness, double vision, gait ataxia, emesis, and left facial and body numbness. Fever, suboccipital headache, and difficulties in urinating and defecating were noted on admission. Acute brainstem infarction and suspected aspiration pneumonia were then diagnosed. Magnetic resonanc...
Source: The American Journal of Emergency Medicine - February 11, 2013 Category: Emergency Medicine Authors: Ming-Hua Chen, Hung-Wen Kao, Chun-An Cheng Tags: Case Reports Source Type: research

Erythropoietin Receptor (EpoR) Agonism Is Used to Treat a Wide Range of Disease.
Abstract The erythropoietin receptor (EpoR) was discovered and described in red blood cells (RBCs), stimulating its proliferation and survival. The target in humans for EpoR agonists drugs appears clear-to treat anemia. However, there is evidence of the pleitropic actions of erythropoietin (Epo). For that reason, rhEpo therapy was suggested as a reliable approach for treating a broad range of pathologies, including heart and cardiovascular diseases, neurodegenerative disorders (Parkinson's and Alzheimer's disease), spinal cord injury, stroke, diabetic retinopathy and rare diseases (Friedreich ataxia). Unfortunatel...
Source: Molecular Medicine - May 23, 2013 Category: Molecular Biology Authors: Sanchis-Gomar F, Perez-Quilis C, Lippi G Tags: Mol Med Source Type: research

The secretome of mesenchymal stem cells: Potential implications for neuroregeneration.
Abstract Mesenchymal stem cells have shown regenerative properties in many tissues. This feature had originally been ascribed to their multipotency and thus their ability to differentiate into tissue-specific cells. However, many researchers consider the secretome of mesenchymal stem cells the most important player in the observed reparative effects of these cells. In this review, we specifically focus on the potential neuroregenerative effect of mesenchymal stem cells, summarize several possible mechanisms of neuroregeneration and list key factors mediating this effect. We illustrate examples of mesenchymal stem ...
Source: Biochimie - July 19, 2013 Category: Biochemistry Authors: Paul G, Anisimov SV Tags: Biochimie Source Type: research

White Matter Changes in Patients with Friedreich Ataxia after Treatment with Erythropoietin
CONCLUSIONSTo the best of our knowledge, this is the first DTI study to investigate the effects of EPO in a neurodegenerative disease. Anatomically, the diffusivity changes appear disease unspecific, and their biological underpinnings deserve further study.
Source: Journal of Neuroimaging - September 9, 2013 Category: Radiology Authors: Karl Egger, Christian Clemm Hohenberg, Michael F. Schocke, Charles R.G. Guttmann, Demian Wassermann, Marlene C. Wigand, Wolfgang Nachbauer, Christian Kremser, Brigitte Sturm, Barbara Scheiber‐Mojdehkar, Marek Kubicki, Martha E. Shenton, Sylvia Boesch Tags: Short Communication Source Type: research

Bilateral cerebellar hemorrhage in vermian vein thrombosis
A 67-year-old previously healthy man presented with sudden onset of headache, vomiting, and instability of stance and gait. Neurologic examination demonstrated bilateral dysmetria of the limbs, ataxia, and scanning speech. Neuroimaging showed bilateral cerebellar hemorrhage and altered signal of the superior vermian vein suggestive for thrombosis (figures 1 and 2). Workup for hematologic, coagulation, and immunologic disorders was negative.
Source: Neurology - October 7, 2013 Category: Neurology Authors: Lattanzi, S., Provinciali, L., Silvestrini, M. Tags: All Cerebrovascular disease/Stroke, Intracerebral hemorrhage, Cerebral venous thrombosis NEUROIMAGES Source Type: research

Anti glutamic acid decarboxylase antibody mediated encephalopathy while on etanercept in a patient with multiple autoimmune diseases
A 39 year old lady presented with an altered mental state and unsteadiness of gait. She had a history of juvenile idiopathic arthritis, autoimmune thyroiditis and alopecia, protein S deficiency with vena cava thrombosis, previous excision of ovarian mass and vasculitic rash. There was a previous history of ovarian mass and her immunomodulatory therapy for arthritis over the previous year was Etanercept. She used recreational cannabis but denied any other illicit drug usage. Her affect was variable and at times inappropriate with frequent laughter. She would spit regularly. There was anxiety and a prevailing sensation of do...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: MacDougall, N., Waddell, B., O'Riordan, J. I. Tags: Immunology (including allergy), Brain stem / cerebellum, Drugs: CNS (not psychiatric), Epilepsy and seizures, Infection (neurology), Stroke, Drugs misuse (including addiction), Connective tissue disease, Musculoskeletal syndromes Association of British Source Type: research

Think outside the box, collapse the box, and take a sharp knife to it!
A 74 year–old woman presented in December 2011 with left sided cerebellar symptoms. She was initially diagnosed as having a posterior circulation infarction and discharged from hospital on appropriate medication. However, over the following month she continued to deteriorate, developing increasing unsteadiness, falls, nausea and vomiting. Following a second admission in January 2012 she had a single seizure and developed focal left sided myoclonus affecting mainly the upper limb. Over the following month the myoclonus spread to affect all four limbs, although it remained more prominent on the left side. There was evi...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Dobson, R., McMillan, A., Kung, K., Thom, M., Davis, A., Simister, R., Giovannoni, G., Gnanapavan, S. Tags: Immunology (including allergy), HIV/AIDS, Tropical medicine (infectious diseases), Brain stem / cerebellum, Epilepsy and seizures, Infection (neurology), Multiple sclerosis, Stroke, Ophthalmology, Radiology, Surgical diagnostic tests Association of Brit Source Type: research