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Condition: Thrombosis

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Total 3681 results found since Jan 2013.

In Reply to the Letter to the Editor Regarding "A neonatal case of cerebral venous sinus thrombosis with intrauterine onset after COVID-19 infection during pregnancy: Cause or coincidence?"
We are grateful to Josef Finsterer for his comments on our recent case regarding the possible association of maternal COVID-19 infection during pregnancy with a neonatal case of intrauterine cerebral sinus venous thrombosis (CSVT). In the letter to editor, he had raised several arguments against a causal relationship, however our case report focused on the plausability of maternal COVID-19 infection as a triggering factor for in utero onset of CVST.
Source: Journal of Stroke and Cerebrovascular Diseases - March 6, 2023 Category: Neurology Authors: Dr Mine Ozdil, Dr İpek Dokurel Cetin Tags: Letter to the Editor Source Type: research

Extra-criteria antiphospholipid antibodies in patients with small vessel brain lesions and clinical manifestations associated with antiphospholipid syndrome
Antiphospholipid syndrome (APS) – as included in the updated APS classification criteria – is characterized by circulating antibodies (Abs) directed against phospholipid-binding proteins or their complex with phospholipids (aPL) and clinical manifestations of thrombosis or gestational morbidity.1 These criteria are very specif ic to ensure homogeneity for some purposes, such as clinical assays, yet they are not very sensitive for APS diagnosis.2 Due to this lack of sensitivity, clinicians must be aware of some entities – distinct from thrombosis fetal losses, or eclampsia – that are not included in the classificati...
Source: Journal of Stroke and Cerebrovascular Diseases - February 24, 2023 Category: Neurology Authors: Miguel Ángel Estévez, Nallibe Lanio, Águeda Molina, Maria Reyes Jiménez-León, María José Picado, Eva Esteban, Sonia Sánchez, Lucio Pallarés, Maria Rosa Julià Source Type: research

Neuromonitoring in Children with Cerebrovascular Disorders
ConclusionsOur understanding of pediatric cerebrovascular disorders has increased dramatically over the past several years, in part due to advances in the neuromonitoring modalities that allow us to better understand these conditions. We are now poised, as a field, to take advantage of advances in neuromonitoring capabilities to determine how best to manage and treat acute cerebrovascular disorders in children.
Source: Neurocritical Care - February 24, 2023 Category: Neurology Source Type: research

Role of lipocalin 2 in stroke
Neurobiol Dis. 2023 Feb 16:106044. doi: 10.1016/j.nbd.2023.106044. Online ahead of print.ABSTRACTStroke is the second leading cause of death worldwide; however, the treatment choices available to neurologists are limited in clinical practice. Lipocalin 2 (LCN2) is a secreted protein, belonging to the lipocalin superfamily, with multiple biological functions in mediating innate immune response, inflammatory response, iron-homeostasis, cell migration and differentiation, energy metabolism, and other processes in the body. LCN2 is expressed at low levels in the brain under normal physiological conditions, but its expression i...
Source: Neurobiology of Disease - February 22, 2023 Category: Neurology Authors: Ruo-Yu Zhao Peng-Ju Wei Xin Sun Dian-Hui Zhang Qian-Yan He Jie Liu Jun-Lei Chang Yi Yang Zhen-Ni Guo Source Type: research

Before blaming SARS-CoV-2 for cerebrovascular disease in children, all differentials need to be ruled out
We read with interest the article by Spanelova et al. about four pediatric patients with cerebrovascular complications after a putative SARS-CoV-2 infection [1]. Patient-1 was diagnosed with subdural hematoma (SDH) and meningitis, patient-2 with cerebral vasculitis, patient-3 with lacunar stroke, and patient-4 with venous sinus thrombosis (VST) with haemorrhage [1]. It was concluded that SARS-CoV-2 infections in children can be complicated by cerebro-vascular disease [1]. The study is promising but raises concerns that should be discussed.
Source: Pediatric Neurology - February 14, 2023 Category: Neurology Authors: Josef Finsterer Tags: Correspondence Source Type: research

Genetic variants in the promoters of let-7 are associated with the risk and age at onset of ischemic stroke: A case control study
Stroke is China's main cause of mortality and years of life lost. With the aging population and increasing urbanization, stroke incidence has risen in China.1 Ischemic stroke (IS) is a multifactorial and multigenic disease that develops when blood supply to a specific part of the brain is disrupted or diminished, generally due to a thrombus. Although there are advancements in recanalization therapy, treatment options for stroke are still limited.2 Identifying genetic variants related to the onset risk of IS could contribute to understanding its pathogenesis and further developing innovative strategies for managing and prev...
Source: Journal of Stroke and Cerebrovascular Diseases - February 11, 2023 Category: Neurology Authors: Yuye Wang, Luying Qiu, Wenjuan Jiang, Meilin Chen, Zhiyi He, Yanzhe Wang, Shumin Deng Source Type: research

Risk factor identification and prediction models for prolonged length of stay in hospital after acute ischemic stroke using artificial neural networks
ConclusionThe artificial neural network model achieved adequate discriminative power for predicting prolonged length of stay after acute ischemic stroke and identified crucial factors associated with a prolonged hospital stay. The proposed model can assist in clinically assessing the risk of prolonged hospitalization, informing decision-making, and developing individualized medical care plans for patients with acute ischemic stroke.
Source: Frontiers in Neurology - February 9, 2023 Category: Neurology Source Type: research

One-Year Survival of Ischemic Stroke Patients Requiring Mechanical Ventilation
ConclusionsThe indication for intubation seems to significantly affect outcome. Functional outcome at 3  months is often poor, but a great majority of 1-year survivors are able to live at home.
Source: Neurocritical Care - February 9, 2023 Category: Neurology Source Type: research

Combination of platelet-to-lymphocyte ratio and D-dimer for the identification of cardiogenic cerebral embolism in non-valvular atrial fibrillation
ConclusionsThe PLR and D-dimer represent an aggravated process of inflammation and thrombosis in the occurrence of CCE after NVAF. The combination of these two risk factors can contribute to identifying the risk of CCE for patients with NVAF with an accuracy of 93.4%, and the greater in change of composite indicator, the shorter in the recurrence of CCE for NVAF patients.
Source: Frontiers in Neurology - February 8, 2023 Category: Neurology Source Type: research

Effects of predictive nursing intervention on cognitive impairment and neurological function in ischemic stroke patients
ConclusionPredictive nursing intervention is beneficial to improve the effects of thrombolytic therapy in patients with ischemic stroke, which improves the neurological, cognitive and motor functions of patients, and reduces the occurrence of complications, suggesting an important clinical application value.
Source: Brain and Behavior - February 4, 2023 Category: Neurology Authors: Lianyu Xue, Jiangshan Deng, Lingyan Zhu, Feifei Shen, Jiewei Wei, Lihui Wang, Qinqin Chen, Lan Wang Tags: ORIGINAL ARTICLE Source Type: research

Effectiveness of alteplase intravenous thrombolysis combined with butylphthalide in patients with acute severe cerebral infarction
CONCLUSIONS: Alteplase intravenous thrombolysis combined with butylphthalide in the treatment of severe cerebral infarction is safe, and may significantly improve patient's neurological function and quality of life without adverse reactions.PMID:36734384 | DOI:10.5114/fn.2022.118787
Source: Folia Neuropathologica - February 3, 2023 Category: Neurology Authors: Zhengqian Wang Junshuang Che Source Type: research