Extra-criteria antiphospholipid antibodies in patients with small vessel brain lesions and clinical manifestations associated with antiphospholipid syndrome

Antiphospholipid syndrome (APS) – as included in the updated APS classification criteria – is characterized by circulating antibodies (Abs) directed against phospholipid-binding proteins or their complex with phospholipids (aPL) and clinical manifestations of thrombosis or gestational morbidity.1 These criteria are very specif ic to ensure homogeneity for some purposes, such as clinical assays, yet they are not very sensitive for APS diagnosis.2 Due to this lack of sensitivity, clinicians must be aware of some entities – distinct from thrombosis fetal losses, or eclampsia – that are not included in the classification criteria but may be related to APS.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research