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Specialty: Neurology
Condition: Thrombosis
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Total 3681 results found since Jan 2013.
Stroke-Specific Predictors of Major Bleeding in Anticoagulated Patients With Stroke and Atrial Fibrillation: A Nationwide Multicenter Registry-Based Study
CONCLUSIONS: This study found that major bleeding risk was independently associated with stroke-specific factors in anticoagulated patients with stroke and AF. This has the clinical implication that baseline characteristics of patients with stroke and AF should be considered in secondary prevention, which would bring the net clinical benefit of balancing recurrent stroke prevention with minimal bleeding complications.PMID:37455504 | DOI:10.3988/jcn.2022.0289
Source: Journal of Clinical Neurology - July 17, 2023 Category: Neurology Authors: Darda Chung Tae-Jin Song Bum Joon Kim Sung Hyuk Heo Jin-Man Jung Kyungmi Oh Chi Kyung Kim Sungwook Yu Kwang Yeol Park Jeong-Min Kim Jong-Ho Park Man-Seok Park Joon-Tae Kim Yang-Ha Hwang Yong-Jae Kim Jong-Won Chung Oh Young Bang Gyeong-Moon Kim Woo-Keun Se Source Type: research
Tenecteplase a First-Line Thrombolytic for LVO Stroke? Tenecteplase a First-Line Thrombolytic for LVO Stroke?
Tenecteplase confers similar reperfusion, safety, and functional outcomes as alteplase in patients with large-vessel occlusion stroke, new research shows.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - July 12, 2023 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
New asymptomatic thrombosis caused by carotid web during the acute period of cerebral infarction
At present, the carotid web (CaW) as an important cause of cryptogenic ischemic stroke has gradually received clinical attention. CaW is associated with a high risk of stroke and patient is more likely to have...
Source: BMC Neurology - July 12, 2023 Category: Neurology Authors: Yan Wang, Hai-Lei Li, Xiao-Hua Xu, Jin-Hao Ye and Jian Li Tags: Case Report Source Type: research
Characteristics and Outcomes of Children with Cerebral Sinus Venous Thrombosis
ConclusionsCSVT, which has a U-shaped age distribution, is an uncommon condition in children. Stroke is common in children with CSVT, and it is associated with an increased need for mechanical ventilation and increased mortality. The need for mechanical ventilation is more common in infants, and it is associated with increased mortality across all age groups.
Source: Neurocritical Care - July 12, 2023 Category: Neurology Source Type: research
Improving door-to-reperfusion time in acute ischemic stroke during the COVID-19 pandemic: experience from a public comprehensive stroke center in Brazil
ConclusionAcute stroke care continued to be a priority despite the COVID-19 pandemic. The implementation of a thrombolytic bolus and the start of continuous infusion on the CT scan table was the main factor that contributed to the reduction of DNT. Continuous monitoring of service times is essential for improving the quality of the stroke center and achieving better functional outcomes for patients.
Source: Frontiers in Neurology - July 10, 2023 Category: Neurology Source Type: research
Factors influencing real-life use of direct oral anticoagulants in patients with cerebral sinus and venous thrombosis
Cerebral sinus and venous thrombosis (CSVT) is a rare subtype of stroke caused by thrombosis of the dural sinuses and cerebral veins which comprises 0.5 –1% of all strokes1,2. The annual incidence ranges from 0.22 to 1.57 per 100,000, most often affecting young adults with a median age of 35 years3-5. Among CSVT patients, the female-to-male ratio is 3:1 and women are significantly younger compared to men6. This is largely due to the increased risk of CSVT associated with oral contraceptives, pregnancy and the puerperium3,7,8.
Source: Journal of Stroke and Cerebrovascular Diseases - July 10, 2023 Category: Neurology Authors: Naaem Simaan, Jeremy Molad, Asaf Honig, Andrei Filioglo, Shlomi Peretz, Fadi Shbat, Tarek Mansor, Waleed Abu-shaheen, Ronen R. Leker Source Type: research
Risk of intracranial hemorrhage with direct oral anticoagulation versus low molecular weight heparin in the treatment of brain tumor-associated venous thromboembolism: A meta-analysis
Direct oral anticoagulants (DOACs) are effective in treating cancer-related thrombosis and are superior to low molecular weight heparin (LMWH) in terms of efficacy. The effects of DOACs or LMWH on intracranial hemorrhage (ICH) remain uncertain in individuals with brain tumors. We conducted a meta-analysis to compare the frequency of ICH in individuals with brain tumors treated with DOACs or LMWH.
Source: Journal of Stroke and Cerebrovascular Diseases - July 4, 2023 Category: Neurology Authors: Jun Yang, Zesong He, Meihua Li, Tao Hong, Taohui Ouyang Source Type: research
Bone marrow mesenchymal stem cell-derived exosomal miR-193b-5p reduces pyroptosis after ischemic stroke by targeting AIM2
Ischemic stroke is a frequently occurring cerebrovascular disease (CVD) linked to high mortality, disability, and incidence rates, and the second factor causing global mortality41,3. There are two common sources of embolism in ischamic strokes: large artery atherosclerosis and small artery atherosclerosis. Ischemic stroke can be treated clinically with thrombolytic therapy4. Although ischemic stroke is treatable, post-cerebral ischemia blood reperfusion frequently induces inflammation, oxidative stress (OS) or additional unfavorable events that may exacerbate brain injury20,24.
Source: Journal of Stroke and Cerebrovascular Diseases - June 30, 2023 Category: Neurology Authors: Yingju Wang, Hongping Chen, Xuehui Fan, Chen Xu, Meng Li, Hongxue Sun, Jihe Song, Feihong Jia, Wan Wei, Fangchao Jiang, Guozhong Li, Di Zhong Source Type: research
Inherited thrombophilia associated with ischemic pediatric stroke in parents-child pairs
We aimed to examine inherited thrombophilia frequencies by extending genetic profile to previously rarely or not-investigated polymorphisms, in children with ischemic pediatric stroke (IPS) and their parents.The study included 33 children: 23 with perinatal (PAIS), 8 with childhood arterial ischemic stroke (CAIS) and 2 with sinovenous thrombosis (SVT) and their parents (33 mother-child, 12 father-child and 12 mother-father-child pairs). Genotyping of FV-Leiden, FV-H1299R, FII-G20210A, β-fibrinogen-455G>A, FXIII-A-Val34Leu, PAI-1(4G/5G), HPA-1, MTHFR-C677T, MTHFR-A1298C, ACE(I/D) and APOE( ε2-4) was performed using CVD St...
Source: Pediatric Neurology - June 27, 2023 Category: Neurology Authors: Jasna Lenicek Krleza, Desiree Coen Herak, Ivana Đakovic, Katarina Vulin, Goran Roic, Ana Tripalo Batoš, Andrea Čeri, Renata Zadro, Vlasta Đuranovic Tags: Research Paper Source Type: research
Predictive role of pre-thrombolytic hs-CRP on the safety and efficacy of intravenous thrombolysis in acute ischemic stroke
To investigate the predictive role of pre-thrombolytic high sensitivity C-reactive protein (hs-CRP) on the safety and efficacy of intravenous thrombolysis in patients with acute ischemic stroke (AIS).
Source: BMC Neurology - June 23, 2023 Category: Neurology Authors: Xu-Dong Cheng, Duo-Zi Wang, Qi Zhang, Jian-Hong Wang, Bing-Hu Li, Xin Zhang, Jing Zhang, Sen Zhou, Li-Jun Jia, Li-Rong Wang and Neng-Wei Yu Tags: Research Source Type: research
Sex differences in acute telestroke care: more to the story
ConclusionWhile treatment differences between sexes existed in the data and were apparent in univariate analysis, no significant difference was seen in multivariate analysis once stroke risk factors, age, NIHSS score and admitting diagnosis were taken into consideration in the telestroke setting. Differences in rates of thrombolysis between sexes may therefore be reflective of differences in risk factors and symptomatology rather than a healthcare disparity.
Source: Frontiers in Neurology - June 21, 2023 Category: Neurology Source Type: research
Blood group and ischemic stroke, myocardial infarction, and peripheral vascular disease: A meta-analysis of over 145,000 cases and 2,000,000 controls
The ABO blood groups have been associated with the pathophysiology of cardiovascular diseases through an influence on two important blood clotting proteins, von Willebrand factor (vWF) and factor FVIII levels (FVIII).1,2 These proteins circulate in the plasma as a complex and are vital in normal haemostasis.1 The highest levels of FVIII and VWF are seen in non-O blood groups. Studies suggest a relationship between non-O blood groups and an increased risk of venous thromboembolism and other thrombotic episodes.
Source: Journal of Stroke and Cerebrovascular Diseases - June 18, 2023 Category: Neurology Authors: Zornitsa Lilova, Faiza Hassan, Malaika Riaz, Joshua Ironside, Gie Ken-Dror, Thang Han, Pankaj Sharma Source Type: research
Rescue therapy after thrombectomy for large vessel occlusion due to underlying atherosclerosis: review of literature
In this review article, we summarized the current advances in rescue management for reperfusion therapy of acute ischemic stroke from large vessel occlusion due to underlying intracranial atherosclerotic stenosis (ICAS). It is estimated that 24–47% of patients with acute vertebrobasilar artery occlusion have underlying ICAS and superimposed in situ thrombosis. These patients have been found to have longer procedure times, lower recanalization rates, higher rates of reocclusion and lower rates of favorable outcomes than patients with embolic occlusion. Here, we discuss the most recent literature regarding the use of glyco...
Source: Frontiers in Neurology - June 16, 2023 Category: Neurology Source Type: research
Multicenter Comparison of the Safety and Efficacy of Clopidogrel Versus Ticagrelor for Neuroendovascular Stents
ConclusionsUsing DAPT-C or DAPT-T regimens in a broad population of neuroendovascular stenting procedures appears to have similar safety and efficacy profiles. Further prospective evaluation is warranted to streamline the practice of DAPT selection and monitoring to determine the impact on clinical outcomes.
Source: Neurocritical Care - June 15, 2023 Category: Neurology Source Type: research
Neuro-Ophthalmic Visual Impairment in the Setting of COVID-19
We describe and elaborate on mechanisms of disease, including para-infectious inflammation, hypercoagulability, endothelial damage, and direct neurotropic viral invasion. Despite global vaccination programs, new variants of COVID-19 continue to pose an international threat, and patients with rare neuro-ophthalmic complications are likely to continue to present for care.Afferent complications from COVID-19 include homonymous visual field loss, with or without higher cortical visual syndromes, resulting from stroke, intracerebral hemorrhage, or posterior reversible leukoencephalopathy. Optic neuritis has frequently been repo...
Source: Seminars in Neurology - June 13, 2023 Category: Neurology Authors: Dinkin, Marc Sathi, Swetha Tags: Review Article Source Type: research
