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Contemporary outcomes of long-term anticoagulation in COVID-19 patients: a regression matched sensitivity analysis of the national inpatient sample
CONCLUSIONS: Compared to COVID-19 patients not on long-term anticoagulation, we observed lower in-hospital mortality, stroke and acute myocardial infarction in COVID-19 patients on long-term anticoagulation. Prospective studies are needed for optimal anticoagulation strategies in hospitalized patients.PMID:37409406 | DOI:10.1080/14779072.2023.2234282
Source: Expert Review of Cardiovascular Therapy - July 6, 2023 Category: Cardiology Authors: Amro Taha Irisha Badu Harigopal Sandhyavenu Varun Victor Sanchit Duhan Lalitsiri Atti Hasham Masood Qureshi Thatiana Schulze Goni Bijeta Keisham Vasantha Sandhya Venu Harshith Thyagaturu Karthik Gonuguntla Waqas Ullah Himanshu Deshwal Sudarshan Balla Source Type: research

Risk of thromboembolism in atrial fibrillation.
Abstract Atrial fibrillation is considered as one of the cardiovascular pandemics of our days due to its increasing prevalence and the significant burden on healthcare systems. Management, especially prevention of thromboembolism associated with the arrhythmia is still a challenge even with recently available treatment options. Herein, the author reviews the possibilities of risk stratification and stroke prevention, which are important to all medical professionals who potentially encounter patients with this arrhythmia. Orv. Hetil., 2016, 157(38), 1511-1515. PMID: 27640617 [PubMed - in process]
Source: Orvosi Hetilap - August 31, 2016 Category: Journals (General) Authors: Csanádi Z Tags: Orv Hetil Source Type: research

Telemedicine Is Here to Stay
COVID-19 has prompted a rapid adoption of telemedicine, a trend that some experts say could have a significant and lasting impact on the medical device industry. Jason Mills, a medtech analyst at Canaccord Genuity, shared conclusions earlier this week from three recent physician surveys that his firm conducted across the structural heart, robotic surgery, and stroke/venous thromboembolism fields. One of the key takeaways is that the overwhelming majority of doctors have "swiftly embraced" telemedicine during the crisis. A look at some of the major telemedicine players' earnings projectio...
Source: MDDI - April 15, 2020 Category: Medical Devices Authors: Amanda Pedersen Tags: COVID-19 Digital Health Source Type: news

Forgetting “routine” deep venous thrombosis and stroke during COVID-19 is a parallel pandemic that will be costly if ignored
The current COVID-19 pandemic has resulted in a huge strategic and clinical change within the UK National Health Service (NHS) to ensure that it can cope with the surge in demand of respiratory patients. However, when attention is acutely shifted, routine care will suffer and that could be deadly for some and enormously expensive for the NHS in the long term. Fig, A, shows the increasing public interest over time relating to COVID-19 search terms in the Google Trends health category for the United Kingdom (UK) over the last 30  days.
Source: Journal of Vascular Surgery - April 29, 2020 Category: Surgery Authors: Steven K. Rogers, Michael Hughes Source Type: research

Understanding the neurotropic characteristics of SARS-CoV-2: from neurological manifestations of COVID-19 to potential neurotropic mechanisms
AbstractCoronavirus disease 2019 (COVID-19), a disease caused by the novel betacoronavirus (SARS-CoV-2), has become a global pandemic threat. The potential involvement of COVID-19 in central nervous system (CNS) has attracted considerable attention due to neurological manifestations presented throughout the disease process. In addition, SARS-CoV-2 is structurally similar to SARS-CoV, and both bind to the angiotensin-converting enzyme 2 (ACE2) receptor to enter human cells. Thus, cells expressing ACE2, such as neurons and glial cells may act as targets and are thus vulnerable to SARS-CoV-2 infection. Here, we have reviewed ...
Source: Journal of Neurology - May 25, 2020 Category: Neurology Source Type: research

Infection as a trigger for cardiovascular disease
A variety of clinical infections including the current pandemic and a variety of physical events such as bee stings and trauma have been documented as triggers of acute cardiovascular illness such as venous thromboembolism, myocardial infarction, and stroke.1 –12 A number of factors have been proposed to explain this association between infection and acute cardiovascular disease including activation of various inflammatory molecules and platelets, endothelial dysfunction, and/or augmented sympathetic nervous activity with release of high levels of cate cholamines into the circulation.
Source: The American Journal of Medicine - July 6, 2020 Category: General Medicine Authors: Joseph S. Alpert Tags: Commentary Source Type: research

Lipoprotein(a) and Its Potential Association with Thrombosis and Inflammation in COVID-19: a Testable Hypothesis
AbstractPurpose of ReviewThe COVID-19 pandemic has infected over> 11 million as of today people worldwide and is associated with significant cardiovascular manifestations, particularly in subjects with preexisting comorbidities and cardiovascular risk factors. Recently, a predisposition for arterial and venous thromboses has been reported in COVID-19 infection. We hypothesize that besides conventional risk factors, subjects with elevated lipoprotein(a) (Lp(a)) may have a particularly high risk of developing cardiovascular complications.Recent FindingsThe Lp(a) molecule has the propensity for inhibiting endogenous fibrin...
Source: Current Atherosclerosis Reports - July 24, 2020 Category: Cardiology Source Type: research

Development of pulmonary embolism in a nonhospitalized patient with COVID-19 who did not receive venous thromboembolism prophylaxis.
CONCLUSION: This case suggests that nonhospitalized patients with COVID-19 may be at higher risk for VTE than patients with other medical illnesses and warrants further research into the risk of VTE in outpatients with COVID-19. PMID: 32780839 [PubMed - as supplied by publisher]
Source: American Journal of Health-System Pharmacy : AJHP - August 10, 2020 Category: Drugs & Pharmacology Authors: Uppuluri EM, Shapiro NL Tags: Am J Health Syst Pharm Source Type: research

The potential role of microvascular pathology in the neurological manifestations of coronavirus infection
We present the hypothesis that pre-existing vascular damage (due to aging, cardiovascular disease, diabetes, hypertension or other conditions) facilitates infiltration of the virus into the central nervous system (CNS), increasing neuro-inflammation and the likelihood o f neurological symptoms. We also discuss the role of a neuroinflammatory cytokine profile in both blood–brain barrier dysfunction and macrovascular disease (e.g. ischemic stroke and thromboembolism). Future studies are needed to better understand the involvement of the microvasculature in coronavi rus neuropathology, and to test the diagnostic potential o...
Source: Fluids and Barriers of the CNS - September 9, 2020 Category: Neuroscience Source Type: research

Comparison of Clinical Outcomes in Patients with ST Elevation Myocardial Infarction with Percutaneous Coronary Intervention and the Use of a Telemedicine App Before and After the COVID-19 Pandemic at a Center in Beijing, China, from August 2019 to March 2020.
CONCLUSIONS Telemedicine reduced the delay time of STEMI patients during the COVID-19 pandemic. The difference in short-term adverse clinical outcomes was not statistically significant between patients who used the app and those who did not. PMID: 32938901 [PubMed - in process]
Source: Medical Science Monitor - September 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research

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