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Source: Thrombosis Research
Condition: Thrombosis
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Total 219 results found since Jan 2013.
Stroke diagnosis associated with thrombophilia testing overutilization
Thrombophilia broadly defines inherited or acquired coagulation disorders associated with increased tendency to form intravascular thrombi [1,2]. Although thrombophilia testing may help providers understand the underlying pathophysiology of a thrombotic event, universal thrombophilia screening for unselected patients presenting with thromboembolism is not recommended [3 –5]. Results of studies in both inpatient and outpatient settings have shown that the clinical utility of thrombophilia tests in anticoagulation management is limited, which potentially decreases cost-effectiveness of the testing [6,7].
Source: Thrombosis Research - July 18, 2017 Category: Hematology Authors: Kibum Kim, Nicholas Cox, Daniel M. Witt Tags: Letter to the Editors-in-Chief Source Type: research
β-Thromboglobulin and incident cardiovascular disease risk: The Atherosclerosis Risk in Communities study
Although it has been suggested that increased concentrations of activated platelet biomarkers are associated with increased risk of incident cardiovascular disease (CVD) in the general population, evidence for this association is still controversial. Thus, we tested the hypothesis that activated platelets, measured by higher concentrations of β-thromboglobulin, are associated with increased risk of incident CVD (coronary heart disease, heart failure ischemic stroke, and atrial fibrillation).
Source: Thrombosis Research - May 17, 2017 Category: Hematology Authors: Yasuhiko Kubota, Alvaro Alonso, Aaron R. Folsom Tags: Full Length Article Source Type: research
Present status and future orientation of rivaroxaban application in patients with nonvulvular atrial fibrillation
Nonvalvular atrial fibrillation (NVAF) is one of the most common supraventricular arrhythmias that require anticoagulation therapy to prevent stroke and systemic embolism. It affects 2% of the European population and is associated with an approximate 5-fold increased stroke risk [1], while in China, the estimated age-standardized AF prevalence was 0.65% in 2008, suggesting that at least 4 million adults had AF [2], and it was predicted that 5.2 million men and 3.1 million women aged>60years will be affected by AF in China by 2050 [3].
Source: Thrombosis Research - May 17, 2017 Category: Hematology Authors: Sui Huang, Liang Tang, Yu Hu Tags: Editorial Source Type: research
Cancer, atrial fibrillation, and stroke
Cancer patients appear to be at increased risk for atrial fibrillation. Although surgery and chemotherapy exacerbate this risk, this association is observed even in the absence of any cancer-specific treatment. The underlying mechanism of this is likely multifactorial, but systemic inflammation and autonomic dysregulation are hypothesized to play critical roles. Cancer and atrial fibrillation are both independent risk factors for ischemic stroke; however, it is not clear whether this translates to an increased risk of stroke in patients with both comorbidities.
Source: Thrombosis Research - May 9, 2017 Category: Hematology Authors: Tess Sudenis, Marc Carrier, Gr égoire Le Gal Tags: Review Article Source Type: research
Nonvitamin K-dependent oral anticoagulants (NOACs) in chronic kidney disease patients with atrial fibrillation
Atrial fibrillation (AF) represents the most common arrhythmia in patients with chronic kidney disease (CKD). As in the general population, in CKD patients AF is associated with an increased risk of thromboembolism and stroke. However, CKD patients, especially those on renal replacement therapy (RRT), also exhibit an increased risk of bleeding, especially from the gastrointestinal tract.Oral anticoagulation is the most effective form of thromboprophylaxis in patients with AF presenting increased risk of stroke.
Source: Thrombosis Research - May 3, 2017 Category: Hematology Authors: L. Di Lullo, C. Ronco, M. Cozzolino, D. Russo, L. Russo, B. Di Iorio, A. De Pascalis, V. Barbera, M. Galliani, E. Vitaliano, C. Campana, F. Santoboni, A. Bellasi Tags: Review Article Source Type: research
Increased expression of TFPI in human carotid stenosis
Tissue factor (TF) pathway inhibitor (TFPI) is the physiological inhibitor of TF induced blood coagulation and two isoforms exists, TFPI α and TFPIβ. In atherosclerotic plaques, TFPI may inhibit TF activity and thrombus formation, which is the main cause of ischemic stroke in carotid artery disease. We aimed to identify the isoforms of TFPI present in human carotid plaques and potential sources of TFPI.
Source: Thrombosis Research - April 27, 2017 Category: Hematology Authors: Benedicte Stavik, Sverre Holm, Sandra Espada, Nina Iversen, Bj ørnar Sporsheim, Vigdis Bjerkeli, Tuva Børresdatter Dahl, Per Morten Sandset, Mona Skjelland, Terje Espevik, Grethe Skretting, Bente Halvorsen Tags: Full Length Article Source Type: research
Efficacy and safety of rivaroxaban versus warfarin in patients from mainland China with nonvalvular atrial fibrillation: A subgroup analysis from the ROCKET AF trial
The ROCKET AF study evaluated once-daily rivaroxaban versus dose-adjusted warfarin for the prevention of stroke and systemic embolism in patients with atrial fibrillation (AF). In this analysis, we compared rivaroxaban with warfarin in patients with AF from China, East Asia, and the rest of the world (ROW).
Source: Thrombosis Research - April 13, 2017 Category: Hematology Authors: Yihong Sun, Dayi Hu, Susanna Stevens, Yuliya Lokhnygina, Richard C. Becker, Scott D. Berkowitz, G ünter Breithardt, Werner Hacke, Jonathan L. Halperin, Graeme J. Hankey, Kenneth W. Mahaffey, Christopher C. Nessel, Jonathan P. Piccini, Daniel E. Singer, K Tags: Full Length Article Source Type: research
Increased circulating leukocyte-derived microparticles in ischemic cerebrovascular disease
In this study, we examined the hypothesis that the quantity of leukocyte-derived microparticles is increased in patients with ischemic cerebrovascular diseases, and investigated utility of various phenotypes of leukocyte-derived microparticles as specific biomarkers of vascular inflammation injury. Additionally we focused on identifying leukocyte-derived microparticles that may be correlated with stroke severity in acute ischemic stroke patients.
Source: Thrombosis Research - April 3, 2017 Category: Hematology Authors: Zhangping He, Yanyan Tang, Chao Qin Tags: Full Length Article Source Type: research
Ischemic stroke in cancer patients treated with direct oral anticoagulants for venous thromboembolism
Direct oral anticoagulants (DOACs) are at least as efficacious as conventional anticoagulation therapy for the initial and long-term treatment of cancer patients with venous thromboembolism (VTE). Whether DOACs are non-inferior to low-molecular-weight heparin for the management of cancer patients with VTE is under investigation. In addition, the efficacy of DOACs for the treatment of cancer patients with arterial thrombosis (e.g., ischemic stroke) remains unclear. Herein, we report on two cancer patients admitted to our hospital with Stage IV gastric adenocarcinoma who were being treated with DOACs due to a history of VTE ...
Source: Thrombosis Research - March 31, 2017 Category: Hematology Authors: Yasufumi Gon, Manabu Sakaguchi, Junji Takasugi, Hideki Mochizuki Tags: Letter to the Editors-in-Chief Source Type: research
Effects of rivaroxaban on coagulation tests in patients with non-valvular atrial fibrillation under real-life conditions
Novel oral anticoagulants (NOACs), such as direct factor Xa inhibitors, are effective alternatives for anticoagulation therapy in stroke prevention in atrial fibrillation patients.
Source: Thrombosis Research - March 7, 2017 Category: Hematology Authors: V.M. Silva, M. Scanavacca, F. Darrieux, C. Cavalheiro-Filho, C.C. Strunz Tags: Letter to the Editors-in-Chief Source Type: research
Depression and post-traumatic stress disorder in individuals with hereditary hemorrhagic telangiectasia: A cross-sectional survey
Hereditary hemorrhagic telangiectasia (HHT) is characterized by frequent severe bleeding, particularly epistaxis, and life-threatening complications including stroke, brain abscess and heart failure. The psychological impact of HHT is not known. We conducted this cross sectional study to determine the prevalence of depression and post-traumatic stress disorder (PTSD) related to HHT.
Source: Thrombosis Research - March 7, 2017 Category: Hematology Authors: Shruti Chaturvedi, Marianne Clancy, Nicole Schaefer, Olalekan Oluwole, Keith McCrae Tags: Full Length Article Source Type: research
Patients' experiences of atrial fibrillation and non-vitamin K antagonist oral anticoagulants (NOACs), and their educational needs: A qualitative study
This study explores patients' experiences of dabigatran and their recommendations for development of educational materials.
Source: Thrombosis Research - March 6, 2017 Category: Hematology Authors: Danielle E Clarkesmith, Gregory Y H Lip, Deirdre A Lane Tags: Full Length Article Source Type: research
Platelet reactivity in patients carrying the e-NOS G894T polymorphism after a loading dose of aspirin plus clopidogrel
Nitric oxide (NO) plays an important role in the modulation of platelet reactivity through platelet recruitment, activation and aggregation. NO is produced by the endothelial NO synthase (eNOS) that is expressed not only in the endothelium but also in platelets [1]. G894T single nucleotide polymorphism of eNOS gene results in the substitution of glutamic acid at codon 298 by aspartic acid. This substitution in the protein sequence is responsible of lower enzyme activity, i.e. lower NO production, and it has been associated with coronary spasm, atherosclerosis, myocardial infarction, and stroke [2 –6].
Source: Thrombosis Research - January 25, 2017 Category: Hematology Authors: Teresa Strisciuglio, Giuseppe Di Gioia, Fabio Mangiacapra, Chiara De Biase, Leen Delrue, Mariano Pellicano, Jozef Bartunek, Marc Vanderheyden, Raffaele Izzo, Bruno Trimarco, William Wijns, Emanuele Barbato Tags: Letter to the Editors-in-Chief Source Type: research
Cancer, other comorbidity, and risk of venous thromboembolism after stroke: a population-based cohort study
The impact of cancer and other comorbidity on the risk of venous thromboembolism (VTE) after stroke is poorly understood.
Source: Thrombosis Research - September 28, 2016 Category: Hematology Authors: Priscila Corraini, Anne Gulbech Ording, Victor W. Henderson, Szimonetta Sz épligeti, Erzsébet Horváth-Puhó, Henrik Toft Sørensen Tags: Original Article Source Type: research
Endothelial cell senescence and thrombosis: Ageing clots
Age is an important cardiovascular risk factor. Among others, age is associated with an increased risk to develop thrombotic cardiovascular complications, both in the arterial (acute myocardial infarction, stroke) and the venous (deep vein thrombosis, pulmonary embolism) system, which cannot be explained by the age-associated increase in cardiovascular risk factors alone. A number of studies have demonstrated that the accumulation of senescent endothelial cells and specific phenotypic and functional alterations associated with endothelial cell senescence may play an important role during the development and progression of ...
Source: Thrombosis Research - September 18, 2016 Category: Hematology Authors: Magdalena L. Bochenek, Eva Sch ütz, Katrin Schäfer Tags: Review Article Source Type: research
