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Source: Thrombosis Research
Condition: Thrombosis
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Total 219 results found since Jan 2013.
Cancer and stroke: What do we know and where do we go?
Cancer is an increasingly recognized cause for ischemic stroke, with recent acknowledgement of cancer-related stroke as an emerging stroke subtype with unique pathophysiologic mechanisms. In addition, cancer-related stroke may differ from stroke in the general population as cancer patients may not receive guideline-recommended stroke care, and the occurrence of stroke may also preclude patients from receiving optimal cancer treatments. Due to the high degree of morbidity and mortality associated with both conditions, understanding the relationship between stroke and cancer is crucial.
Source: Thrombosis Research - September 16, 2022 Category: Hematology Authors: Ronda Lun, Deborah Siegal, Tim Ramsay, Dar Dowlatshahi Source Type: research
Clopidogrel High-on-Treatment Platelet Reactivity in Acute Ischemic Stroke Patients
Conclusions: Clopidogrel-HTPR was found in 44% of the patients with acute ischemic stroke. Besides time-dependency of the clopidogrel effect, major risk factors for clopidogrel-HTPR were diabetes mellitus and higher HbA1c values. Further investigations are required to analyse if a function test guided strategy has the potential to optimize the antiplatelet therapy of acute stroke patients.
Source: Thrombosis Research - January 9, 2014 Category: Hematology Authors: Saskia H. Meves, Kay D. Schröder, Heinz G. Endres, Christos Krogias, Jan C. Krüger, Horst Neubauer Tags: Platelets and cell biology Source Type: research
Metabolic syndrome, platelet activation and the development of transient ischemic attack or thromboembolic stroke
Stroke is the second most common cause of mortality in the world today, where transient ischemic attack (TIA) is a period of focal ischemia, the symptoms of which resemble a thromboembolic stroke. Contrary to stroke, TIA symptoms typically last less than one hour and necrosis is absent. Stroke is often preceded by TIA, making it an important predictor of future ischemic events. The causal role of atherosclerosis in the development of TIA is well established, however, research indicates that the atherosclerotic process begins years earlier with the development of metabolic syndrome, which affects approximately 45% of the ad...
Source: Thrombosis Research - January 16, 2015 Category: Hematology Authors: Mia-Jeanne van Rooy, Etheresia Pretorius Tags: Review Article Source Type: research
Pregnancy related stroke in the setting of homozygous type-II HBS antithrombin deficiency
Stroke is defined as a focal or global disturbance of cerebral function lasting over 24h; resulting from disruption of blood supply [1]. Stroke during pregnancy is fortunately a rare event, but it can have severe consequences, such as long-term disability or death, with 9.5% of all maternal deaths being related to stroke [2]. The overall risk of pregnancy-related stroke was 34.2 (95% CI 33.3–35.1) per 100000 deliveries in the USA, with 48% occurring postpartum, 41% at the time of delivery and 11% antepartum [3].
Source: Thrombosis Research - January 27, 2016 Category: Hematology Authors: Mirjana Kovac, Gorana Mitic, Zeljko Mikovic, Vesna Mandic, Valentina Djordjevic, Laszlo Muszbek, Zsuzsanna Bereczky Tags: Correspondence Source Type: research
Cancer diagnosis as a risk factor of ischemic stroke in atrial fibrillation patients with low stroke risk score
Introduction: Atrial fibrillation (AF) is a well known risk factor of ischemic stroke (IS). Patients categorized as low risk according to stroke risk scores are not routinely recommended anticoagulation prophylaxis. Cancer is known to increase the risk of IS, but it is not clear to what extent cancer is a risk factor of IS in AF patients with low stroke risk score.
Source: Thrombosis Research - April 1, 2018 Category: Hematology Authors: A. Atterman, B. Gigante, K. Asplund, S. Aspberg Tags: PO-25 Source Type: research
The pathogenesis of aging-induced left atrial appendage thrombus formation and cardioembolic stroke in mice is influenced by inflammation-derived matrix metalloproteinases
Elderly people without atrial fibrillation (AF) still have a high incidence of cardioembolic stroke, suggesting that thrombus formation within the left atrial appendage (LAA) may also occur in an AF-independent manner. In the present study, we explored the potential mechanisms for aging-induced LAA thrombus formation and stroke in mice. We monitored stroke events in 180 aging male mice (14 –24 months) and assessed left atrium (LA) remodeling by echocardiography at different ages. Mice that had stroke were implanted with telemeters to confirm AF.
Source: Thrombosis Research - April 25, 2023 Category: Hematology Authors: Ruopeng Tan, Mengyang Yuan, Lin Wang, Jingjie Liu, Guinan Jiang, Jiawei Liao, Yun-Long Xia, Xiaomeng Yin, Yang Liu Source Type: research
Oral Contraceptive Use and Incident Stroke in Women with Sickle Cell Disease
Oral contraceptives increase the risk of ischemic stroke among women. However, the effect is not studied in the stroke prone sickle cell disease population. We want to determine the rate of incident stroke among women with sickle cell disease (SCD) enrolled in a large cohort with longitudinal follow-up.
Source: Thrombosis Research - April 13, 2015 Category: Hematology Authors: Adnan I. Qureshi, Ahmed A. Malik, Malik M. Adil, M. Fareed K. Suri Tags: Regular article Source Type: research
Prevention and follow-up in thromboembolic ischemic stroke: Do we need to think out of the box?
Stroke is one of the most debilitating thrombotic diseases, and world-wide it is estimated that by, 2030 23 million people will be affected. Except for the impact on the individual families, the world economy is also affected adversely. Although the medical treatment and knowledge of stroke are both increasing and well-researched, we still do not see a light in the tunnel. Currently various diagnostic tests are employed to determine the specific type of ischemic stroke as classified by the TOAST criteria.
Source: Thrombosis Research - November 4, 2015 Category: Hematology Authors: Albe C. Swanepoel, Etheresia Pretorius Tags: Review Article Source Type: research
Clinical and laboratory predictors of deep vein thrombosis after acute stroke
Deep vein thrombosis (DVT) is a common complication of acute stroke, but the new incidence in the era of improved specialist input in stroke care is yet unknown. The models for VTE diagnosis is well established, but prediction models to target at-risk patients for pharmacological prophylaxis is lacking and requires further research, particularly in the aftermath of acute stroke.
Source: Thrombosis Research - April 8, 2016 Category: Hematology Authors: Ibrahim O. Balogun, Lara N. Roberts, Raj Patel, Rohan Pathansali, Lalit Kalra, Roopen Arya Tags: Full Length Article Source Type: research
Clinical and laboratory predictors of deep vein thrombosis after acute stroke; does D-dimer really improve predictive power?
We have read with great interest the paper “Clinical and laboratory predictors of deep vein thrombosis after acute stroke” by Balogun et al. [1], in which the authors investigate the interesting and relevant topic of deep vein thrombosis (DVT) prediction after acute stroke. Specifically, their main research question focusses on the predictive value of stroke severity score and markers of haemostatic activation. This is a relevant question as venous thrombosis, mainly manifested as DVT and pulmonary embolism, is regarded as a serious, potentially life-threatening complication in stroke patients, even though the reports ...
Source: Thrombosis Research - July 3, 2016 Category: Hematology Authors: Vasilis Kola, Hugoline de Haan, Bob Siegerink Tags: Correspondence Source Type: research
Cancer-associated ischemic stroke: A retrospective multicentre cohort study
The association between stroke and cancer is well-known but insufficiently investigated. Aim of this multicentre retrospective cohort study was to estimate the prevalence of cancer-associated ischemic stroke, describe clinical outcomes in patients with cancer-associated ischemic stroke and investigate independent factors associated with active cancer.
Source: Thrombosis Research - March 14, 2018 Category: Hematology Authors: Stefano Grazioli, Maurizio Paciaroni, Giancarlo Agnelli, Monica Acciarresi, Andrea Alberti, Cataldo D'Amore, Valeria Caso, Michele Venti, Luigina Guasti, Walter Ageno, Alessandro Squizzato Tags: Full Length Article Source Type: research
Patent foramen ovale increases the risk of acute ischemic stroke in patients with acute pulmonary embolism leading to right ventricular dysfunction
Patent foramen ovale (PFO) is an established risk factor for ischemic stroke. Since acute right ventricular dysfunction (RVD) observed in patients with PE can lead to right-to-left inter-atrial shunt via PFO, we hypothesized that PFO is a risk factor for ischemic stroke in PE with significant right ventricular dysfunction.
Source: Thrombosis Research - September 18, 2014 Category: Hematology Authors: Sylwia Goliszek, Małgorzata Wiśniewska, Katarzyna Kurnicka, Barbara Lichodziejewska, Michał Ciurzyński, Maciej Kostrubiec, Marek Gołębiowski, Marek Babiuch, Marzanna Paczynska, Marcin Koć, Piotr Palczewski, Anna Wyzgał, Piotr Pruszczyk Tags: Regular Article Source Type: research
