The pathogenesis of aging-induced left atrial appendage thrombus formation and cardioembolic stroke in mice is influenced by inflammation-derived matrix metalloproteinases

Elderly people without atrial fibrillation (AF) still have a high incidence of cardioembolic stroke, suggesting that thrombus formation within the left atrial appendage (LAA) may also occur in an AF-independent manner. In the present study, we explored the potential mechanisms for aging-induced LAA thrombus formation and stroke in mice. We monitored stroke events in 180 aging male mice (14 –24 months) and assessed left atrium (LA) remodeling by echocardiography at different ages. Mice that had stroke were implanted with telemeters to confirm AF.

Source: Thrombosis Research - April 25, 2023 Category: Hematology Authors: Ruopeng Tan, Mengyang Yuan, Lin Wang, Jingjie Liu, Guinan Jiang, Jiawei Liao, Yun-Long Xia, Xiaomeng Yin, Yang Liu Source Type: research