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Source: Thrombosis Research
Condition: Thrombosis
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Total 219 results found since Jan 2013.
Cancer as a risk factor for stroke in atrial fibrillation patients receiving long-term oral anticoagulant therapy
cancer and cerebrovascular disease are among the most common causes of death in the developed countries and are both associated with a steep increase in incidence among the elderly population. Despite being a less frequent neurological complication in cancer patients, compared to metastases or neurotoxicity from anticancer treatment, stroke incidence in cancer patients is high [1]. The pathophysiology of stroke in cancer patients is largely unknown [2] and can be attributed to cardiac or non-cardiac embolism.
Source: Thrombosis Research - June 18, 2015 Category: Hematology Authors: Gentian Denas, Vittorio Pengo, Roberta Joppi, Paolo Prandoni Source Type: research
Lack Of Tafi Increases Brain Damage And Microparticle Generation After Thrombolytic Therapy In Ischemic Stroke
Thrombin-activatable fibrinolysis inhibitor (TAFI) plays an important role in coagulation and fibrinolysis. Whereas TAFI deficiency may lead to a haemorrhagic tendency, data from TAFI knockout mice (TAFI−/−) are controversial and no differences have been reported in these animals after ischemic stroke. There are also no data regarding the role of circulating microparticles (MPs) in TAFI−/−.
Source: Thrombosis Research - June 10, 2015 Category: Hematology Authors: Orbe J, Alexandru N, Roncal C, Belzunce M, Bibiot P, Rodriguez JA, Meijers JCM, Georgescu A, Paramo JA Source Type: research
Denser plasma clot formation and impaired fibrinolysis in paroxysmal and persistent atrial fibrillation while on sinus rhythm: Association with thrombin generation, endothelial injury and platelet activation
Formation of compact and poorly lysable fibrin clots have been demonstrated in patients following ischemic stroke. Recently, it has been shown that denser fibrin networks and impaired fibrinolysis occurs in subjects with permanent atrial fibrillation (AF). Fibrin clot phenotype in other types of AF remains to be established. We evaluated fibrin clot properties in paroxysmal (PAF) and persistent AF (PsAF).
Source: Thrombosis Research - May 28, 2015 Category: Hematology Authors: Leszek Drabik, Paweł Wołkow, Anetta Undas Source Type: research
Clinical evaluation of laboratory methods to monitor apixaban treatment in patients with atrial fibrillation
The direct factor-Xa inhibitor apixaban is approved e.g. for the prevention of stroke in patients with atrial fibrillation (AF). Although routine monitoring of apixaban therapy is currently not recommended, selective monitoring could be useful to optimize efficacy and safety in certain clinical situations. We studied the exposure and effect of apixaban using different laboratory methods in a clinical setting with a well-defined cohort of AF patients.
Source: Thrombosis Research - April 29, 2015 Category: Hematology Authors: Mika Skeppholm, Fadiea Al-Aieshy, Maria Berndtsson, Faris Al-Khalili, Yuko Rönquist-Nii, Lisbeth Söderblom, Annika Y. Östlund, Anton Pohanka, Jovan Antovic, Rickard E. Malmström Tags: Regular Article Source Type: research
Current use of oral contraceptives and the risk of first-ever ischemic stroke: A meta-analysis of observational studies
: To evaluate the risk of first-ever ischemic stroke associated with current use of oral contraceptive pills (OCPs), and to describe how the risk was influenced by estrogen dose, progestin type, and study characteristics.
Source: Thrombosis Research - April 24, 2015 Category: Hematology Authors: Zhenlin Xu, Ying Li, Shaowen Tang, Xiaoping Huang, Tong Chen Tags: Regular Article Source Type: research
Oral Contraceptive Use and Incident Stroke in Women with Sickle Cell Disease
Oral contraceptives increase the risk of ischemic stroke among women. However, the effect is not studied in the stroke prone sickle cell disease population. We want to determine the rate of incident stroke among women with sickle cell disease (SCD) enrolled in a large cohort with longitudinal follow-up.
Source: Thrombosis Research - April 13, 2015 Category: Hematology Authors: Adnan I. Qureshi, Ahmed A. Malik, Malik M. Adil, M. Fareed K. Suri Tags: Regular article Source Type: research
The free-radical scavenger edaravone accelerates thrombolysis with alteplase in an experimental thrombosis model
Reperfusion injury after thrombolytic therapy can have adverse neurologic effects. The free-radical scavenger edaravone is used in combination with the recombinant tissue plasminogen activator alteplase to treat acute ischemic stroke. However, basic investigations of this combination use remain inadequate. Here, we used an in vivo model to investigate the effects of edaravone on alteplase-induced thrombolysis.
Source: Thrombosis Research - April 13, 2015 Category: Hematology Authors: Tsutomu Yamashita, Takumi Sato, Kumi Sakamoto, Hiromitsu Ishii, Junichiro Yamamoto Tags: Regular article Source Type: research
Safety of the direct-acting anticoagulants in patients with atrial fibrillation: a meta-analysis
: Atrial fibrillation (AF) is known as one of the independent risk factors for stroke and might significantly increase its risk. Nowadays, direct-acting oral anticoagulants (DOACs) have been developed and demonstrated a more promising option to warfarin, the conclusion for safety is heterogeneous in different studies. It indicates the importance of comprehensive comparison of safety between DOACs and warfarin.
Source: Thrombosis Research - April 10, 2015 Category: Hematology Authors: Fen Rong, Bin Jia, Pinxian Huang, Henry S. Lynn, Wei Zhang Tags: Regular Article Source Type: research
Anticoagulation for stroke prevention in new atrial fibrillation after coronary artery bypass graft surgery
The benefit of early anticoagulation for stroke prophylaxis in atrial fibrillation after coronary artery bypass graft (CABG) surgery is uncertain. We therefore studied what proportion of ischemic strokes in patients with atrial fibrillation early after CABG surgery were potentially preventable by anticoagulation with warfarin.
Source: Thrombosis Research - February 24, 2015 Category: Hematology Authors: S. Schulman, I. Cybulsky, J. Delaney Tags: Regular Article Source Type: research
Metabolic syndrome, platelet activation and the development of transient ischemic attack or thromboembolic stroke
Stroke is the second most common cause of mortality in the world today, where transient ischemic attack (TIA) is a period of focal ischemia, the symptoms of which resemble a thromboembolic stroke. Contrary to stroke, TIA symptoms typically last less than one hour and necrosis is absent. Stroke is often preceded by TIA, making it an important predictor of future ischemic events. The causal role of atherosclerosis in the development of TIA is well established, however, research indicates that the atherosclerotic process begins years earlier with the development of metabolic syndrome, which affects approximately 45% of the ad...
Source: Thrombosis Research - January 16, 2015 Category: Hematology Authors: Mia-Jeanne van Rooy, Etheresia Pretorius Tags: Review Article Source Type: research
Normal Platelet Activation Profile in Patients with Peripheral Arterial Disease on Aspirin
Peripheral arterial disease (PAD) is a progressive vascular disease associated with a high risk of cardiovascular morbidity and death. Antithrombotic prevention is usually applied by prescribing the antiplatelet agent aspirin. However, in patients with PAD aspirin fails to provide protection against myocardial infarction and death, only reducing the risk of ischemic stroke. Platelets may play a role in disease development, but this has not been tested by proper mechanistic studies. In the present study, we performed a systematic evaluation of platelet reactivity in whole blood from patients with PAD using two high-throughput assays, i.e.
Source: Thrombosis Research - January 5, 2015 Category: Hematology Authors: Johanna P. van Geffen, Marie-Claire Kleinegris, Remco Verdoold, Constance C.F.M.J. Baaten, Judith M.E.M. Cosemans, Kenneth J. Clemetson, Hugo ten Cate, Mark Roest, Bas de Laat, Johan W.M. Heemskerk Tags: Regular article Source Type: research
Safety of venous thromboembolism prophylaxis with fondaparinux in ischemic stroke
We examined adverse event frequency in hospitalized patients with ischemic stroke who received VTE prophylaxis with fondaparinux versus UFH.
Source: Thrombosis Research - December 13, 2014 Category: Hematology Authors: C.T. Hackett, R.S. Ramanathan, K. Malhotra, M.R. Quigley, K.M. Kelly, M. Tian, J. Protetch, C. Wong, D.G. Wright, A.H. Tayal Tags: Regular Article Source Type: research
The use of aspirin for primary and secondary prevention in venous thromboembolism and other cardiovascular disorders
Cardiovascular disease (CVD) includes a number of conditions such as myocardial infarction, coronary heart disease, stroke, and venous thromboembolism. CVD is a leading health problem worldwide and a major cause of mortality, morbidity, and disability; it is also associated with high healthcare costs. The incidence of CVD is predicted to increase in the forthcoming years, and thus it is crucial that physicians are aware of the benefits and limitations of the available therapies to ensure patients receive optimized treatment.
Source: Thrombosis Research - December 12, 2014 Category: Hematology Authors: A.T. Cohen, S. Imfeld, J. Markham, S. Granziera Tags: Review Article Source Type: research
Elevated Circulating VE-Cadherin+CD144+Endothelial Microparticles in Ischemic Cerebrovascular Disease
Circulating endothelial microparticles act as biological markers of endothelial function that reflect vascular injury. Here, we examined the hypothesis that the quantity of endothelial microparticles in the circulation is increased in patients with ischemic cerebrovascular diseases, and investigated the potential utility of various phenotypes of endothelial microparticles as specific biomarkers of endothelial cell dysfunction. We additionally focused on identifying endothelial microparticles that may be effectively utilized as biomarkers of stroke severity in acute ischemic stroke patients.
Source: Thrombosis Research - December 5, 2014 Category: Hematology Authors: Pingping Li, Chao Qin Tags: Regular Article Source Type: research
Venous thrombosis and risk of cancer in patients with arterial cardiovascular disease
We examined the association between venous thromboembolism and cancer in patients with acute myocardial infarction or stroke.
Source: Thrombosis Research - November 13, 2014 Category: Hematology Authors: Sigrun Alba Johannesdottir Schmidt, Dóra Körmendiné Farkas, Lars Pedersen, Paolo Prandoni, Henrik Toft Sørensen Source Type: research
