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Source: Thrombosis Research
Condition: Thrombosis
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Total 219 results found since Jan 2013.
D-dimer to fibrinogen ratio predicts early neurological deterioration in ischemic stroke with atrial fibrillation
The D-dimer to fibrinogen ratio (DFR) is a good indicator of clot-producing activity in thrombotic disease, but its clinical usefulness in stroke patients with nonvalvular atrial fibrillation (NVAF) has not been studied. We evaluated the association between the DFR and early neurological deterioration (END) in acute ischemic stroke (AIS) patients with NVAF.
Source: Thrombosis Research - July 31, 2023 Category: Hematology Authors: Ki-Woong Nam, Chi Kyung Kim, Sungwook Yu, Kyungmi Oh, Jong-Won Chung, Oh. Young Bang, Gyeong-Moon Kim, Jin-Man Jung, Tae-Jin Song, Yong-Jae Kim, Bum Joon Kim, Sung Hyuk Heo, Kwang-Yeol Park, Jeong-Min Kim, Jong-Ho Park, Jay Chol Choi, Man-Seok Park, Joon- Tags: Full Length Article Source Type: research
Barriers and facilitators for adherence to direct oral anticoagulants in patients with atrial fibrillation: A qualitative approach
Direct oral anticoagulants (DOACs) are the cornerstone for stroke prevention in patients with atrial fibrillation (AF) [1]. DOAC non-adherence and discontinuation have been associated with higher thromboembolic and mortality risks [2]. Until now, studies trying to optimise adherence to DOACs show disappointing results with limited effectiveness of interventions [3]. An explanation might be that medication (non-)adherence is a very complex behaviour in which different determinants, varying between patients, play a role.
Source: Thrombosis Research - June 14, 2023 Category: Hematology Authors: Andreas Capiau, Maxim Grymonprez, Sophie Scheire, Yenna Faute, Lies Lahousse, Els Mehuys, Tine De Backer, Koen Boussery Tags: Letter to the Editors-in-Chief Source Type: research
Clinical effectiveness and safety of edoxaban in obese patients — Results of the prospective Dresden NOAC Registry (NCT01588119)
Edoxaban is a direct factor Xa inhibitors approved for stroke prevention in atrial fibrillation (SPAF) and for venous thromboembolism (VTE) treatment. Edoxaban is given in a fixed dosing regimen (with recommended dose reductions for patients with renal impairment or body weight
Source: Thrombosis Research - June 2, 2023 Category: Hematology Authors: Luise Tittl, Christina K öhler, Sandra Marten, Christiane Naue, Kristina Fache, Laura Stanneck, Thomas Schreier, Jan Beyer-Westendorf Tags: Letter to the Editors-in-Chief Source Type: research
Predicting functional outcomes after acute ischemic stroke – Is thrombelastography useful outside perioperative bleeding management?
We read with great interest the recent publication by Ryu et al., on the utility of thrombelastography (TEG) as a prognosticator of functional outcomes after ischemic stroke among patients that underwent endovascular treatment (EVT) [1]. The authors suggested that a hypercoagulable signal on TEG, being a reaction time
Source: Thrombosis Research - May 12, 2023 Category: Hematology Authors: Amir Butt, Anna Miller, Kenichi Tanaka, Kenneth Stewart Tags: Letter to the Editors-in-Chief Source Type: research
Electronic alerts for ambulatory patients with atrial fibrillation not prescribed anticoagulation: A randomized, controlled trial (AF-ALERT2)
Despite widely available risk stratification tools, safe and effective anticoagulants, and guideline recommendations, anticoagulation for stroke prevention in atrial fibrillation (AF) is under-prescribed in ambulatory patients. To assess the impact of alert-based computerized decision support (CDS) on anticoagulation prescription in ambulatory patients with AF and high-risk for stroke, we conducted this randomized controlled trial.
Source: Thrombosis Research - May 10, 2023 Category: Hematology Authors: Gregory Piazza, Shelley Hurwitz, Umberto Campia, Behnood Bikdeli, Junyang Lou, Candrika D. Khairani, Antoine Bejjani, Julia E. Snyder, Mariana Pfeferman, Briana Barns, Samantha Rizzo, Alexandra Glezer, Samuel Z. Goldhaber Tags: Full Length Article Source Type: research
The pathogenesis of aging-induced left atrial appendage thrombus formation and cardioembolic stroke in mice is influenced by inflammation-derived matrix metalloproteinases
Elderly people without atrial fibrillation (AF) still have a high incidence of cardioembolic stroke, suggesting that thrombus formation within the left atrial appendage (LAA) may also occur in an AF-independent manner. In the present study, we explored the potential mechanisms for aging-induced LAA thrombus formation and stroke in mice. We monitored stroke events in 180 aging male mice (14 –24 months) and assessed left atrium (LA) remodeling by echocardiography at different ages. Mice that had stroke were implanted with telemeters to confirm AF.
Source: Thrombosis Research - April 25, 2023 Category: Hematology Authors: Ruopeng Tan, Mengyang Yuan, Lin Wang, Jingjie Liu, Guinan Jiang, Jiawei Liao, Yun-Long Xia, Xiaomeng Yin, Yang Liu Source Type: research
Thromboelastography as a predictor of functional outcome in acute ischemic stroke patients undergoing endovascular treatment
Thromboelastography (TEG) is a useful for predicting hemorrhagic transformation, early neurological deterioration, and functional outcome after stroke. We aimed to investigate whether TEG value could also be useful in predicting functional outcome via various intraprocedural and postprocedural factors in patients with acute large vessel occlusive stroke who underwent intraarterial thrombectomy (IAT).
Source: Thrombosis Research - March 31, 2023 Category: Hematology Authors: Jae-Chan Ryu, Seunguk Jung, Jae-Han Bae, Sang Hee Ha, Bum Joon Kim, Sang-Beom Jeon, Dong-Wha Kang, Sun U. Kwon, Jong S. Kim, Jun Young Chang Tags: Full Length Article Source Type: research
Hypercoagulability evaluation in congenital red blood cell disorders using thrombin generation assay
Congenital red blood cell (RBC) disorders are common diseases in the general population. The main outcomes are increased deformability due to erythrocyte instability, increased susceptibility to oxidative stress, and intravascular hemolysis. Hemolytic anemia is associated with thrombosis risk [1]. Main mechanisms are related to hypercoagulability, endothelial damage, altered blood flow, and decreased nitric oxide. Hypercoagulability is well documented in sickle cell disease (SCD) [2]. However, other RBC disorders are associated with pulmonary embolism, hypertension, non-ischemic stroke, and adverse vascular manifestations ...
Source: Thrombosis Research - March 23, 2023 Category: Hematology Authors: Guillaume Feugray, Maximilien Grall, C écile Dumesnil, Ygal Benhamou, Valery Brunel, Véronique Le Cam Duchez, Agnès Lahary, Paul Billoir Tags: Letter to the Editors-in-Chief Source Type: research
Air pollution impacts on in-hospital case-fatality rate of ischemic stroke patients
A growing body of evidence suggests that air pollution exposure is associated with an increased risk for cardiovascular diseases. Data regarding the impact of long-term air pollution exposure on ischemic stroke mortality are sparse.
Source: Thrombosis Research - March 22, 2023 Category: Hematology Authors: Karsten Keller, Seyed Hamed Rastguye Haghi, Omar Hahad, Irene Schmidtmann, Sourangsu Chowdhury, Jos Lelieveld, Thomas M ünzel, Lukas Hobohm Source Type: research
DOACs plasma levels in relation to clinical outcome. How far have we come?
Direct oral anticoagulants (DOACs) are the preferred treatment for prevention of ischemic stroke (IS) and systemic embolism (SE) in nonvalvular atrial fibrillation (NVAF) and treatment or prevention of venous thromboembolism (VTE) [1]. DOACs are administered in fixed doses and do not require routine laboratory monitoring [2]. Nonetheless, high interindividual variability of DOAC blood levels has been reported and the correlation between DOAC plasma levels and clinical outcome is still a grey area.
Source: Thrombosis Research - March 3, 2023 Category: Hematology Authors: Rosa Talerico, Roberto Pola, Menno Volkert Huisman, Frederikus Albertus Klok Tags: Letter to the Editors-in-Chief Source Type: research
DOACs plasma levels in relation to clinical outcome. How far have wecome?
Direct oral anticoagulants (DOACs) are the preferred treatment for prevention of ischemic stroke (IS) and systemic embolism (SE) in nonvalvular atrial fibrillation (NVAF) and treatment or prevention of venous thromboembolism (VTE) [1]. DOACs are administered in fixed doses and do not require routine laboratory monitoring [2]. Nonetheless, high interindividual variability of DOAC blood levels has been reported and the correlation between DOAC plasma levels and clinical outcome is still a grey area.
Source: Thrombosis Research - March 3, 2023 Category: Hematology Authors: Rosa Talerico, Roberto Pola, Menno Volkert Huisman, Frederikus Albertus Klok Tags: Letter to the Editors-in-Chief Source Type: research
Recurrent thrombotic events after disappearance of antiphospholipid autoantibodies: A long-term longitudinal study in patients with antiphospholipid syndrome
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the occurrence of thrombosis and/or pregnancy morbidity related to the presence of persistent antiphospholipid autoantibodies (aPL) [1]. The most frequent clinical manifestations of APS are thrombotic events and death may be caused by stroke, myocardial infarction, pulmonary embolism or catastrophic APS [2]. APS treatment is based on long term anticoagulation [3].
Source: Thrombosis Research - February 9, 2023 Category: Hematology Authors: Thomas Ballul, Arthur Mageau, Pascale Roland Nicaise, Nadine Ajzenberg, Andrey Strukov, Antoine Dossier, Diane Rouzaud, Thomas Papo, Karim Sacr é Tags: Letter to the Editors-in-Chief Source Type: research
Letter to the Editor Re “Endovascular thrombectomy or bridging therapy in minor ischemic stroke with large vessel occlusion”
We commend Tu et al. on the recent article on comparison of endovascular thrombectomy (EVT) versus bridging therapy (BT) in minor stroke patients with large vessel occlusion (LVO) [1]. Based on retrospective, observational study of 903 patients, the authors conclude non-inferiority of EVT compared to BT in patients presenting within 4.5 h of onset. We have a few questions and comments.
Source: Thrombosis Research - January 24, 2023 Category: Hematology Authors: Ajay Malhotra, Mihir Khunte, Xiao Wu, Mahla Radmard Tags: Letter to the Editors-in-Chief Source Type: research
A response to a letter to the editor TR-D-22-00887
In this study, we found that among patients with minor acute ischemic stroke due to large vessel occlusions (AIS-LVO), direct endovascular thrombectomy (EVT), compared with bridging therapy, met the prespecified statistical threshold for noninferiority for the 3-month prognosis [1].
Source: Thrombosis Research - January 16, 2023 Category: Hematology Authors: Wen-Jun Tu, Yicheng Xu Tags: Letter to the Editors-in-Chief Source Type: research
Stroke mortality in cancer survivors: A population-based study in Japan
The association between cancer survivors and stroke deaths remains unclear. We aimed to evaluate the risk of fatal stroke in patients with cancer.
Source: Thrombosis Research - January 9, 2023 Category: Hematology Authors: Yasufumi Gon, Ling Zha, Tsutomu Sasaki, Toshitaka Morishima, Yuko Ohno, Hideki Mochizuki, Tomotaka Sobue, Isao Miyashiro Source Type: research
