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Source: Thrombosis Research
Condition: Thrombosis
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Total 219 results found since Jan 2013.
Soluble P-selectin: The next step
It has long been recognised that platelets are implicated in both mortality and morbidity in the pathophysiology of a variety of conditions, including coronary artery disease , diabetes , cancer , stroke , and deep vein thrombosis . The success of aspirin in reducing thrombotic events, and the prognostic value of platelet volume, numbers and function in predicting cardiovascular death are further evidence of the importance of this cell. Consequently, the ability to accurately identify those subjects at risk of thrombosis, and possibly those experiencing an acute thrombotic event, is highly sought-after if risk reduction an...
Source: Thrombosis Research - November 11, 2013 Category: Hematology Authors: Andrew D. Blann Tags: Editorials Source Type: research
Markers of endothelial dysfunction differ between subphenotypes in children with sickle cell disease
Abstract: In adult patients with sickle cell disease two distinct subphenotypes have previously been defined: patients with the viscosity-vaso-occlusion subphenotype (VVO) suffer mainly from vaso-occlusive pain crises and have a relatively high hemoglobin concentration. Patients classified as the hemolysis-endothelial dysfunction subphenotype (HED) suffer from stroke and pulmonary hypertension and have an elevated concentration of lactate dehydrogenase. However, this classification is not possible in children due to low rates of complications. We used laboratory markers to classify children into the two subphenotypes, and ...
Source: Thrombosis Research - October 31, 2013 Category: Hematology Authors: Veronica van der Land, Marjolein Peters, Bart J. Biemond, Harriët Heijboer, Cornelis L. Harteveld, Karin Fijnvandraat Tags: Platelets and Cell Biology Source Type: research
Protein S deficiency and Heerlen polymorphism in a Polish patient with acute myocardial infarction and previous venous thromboembolism
Protein S (PS) deficiency is an autosomal dominant disorder with a prevalence of less than 0.5% in the general European population and 2% to 12% in thrombophilic patients . This deficiency is most frequently caused by missense mutations (HGMD database, http://www.hgmd.org) in the PS gene (PROS1) located on chromosome 3 . Hereditary PS deficiency is an established risk factor for venous thromboembolism (VTE), and few reports have linked this thrombophilic factor with myocardial infarction (MI) or ischemic stroke .
Source: Thrombosis Research - October 10, 2013 Category: Hematology Authors: Ewa Wypasek, Daniel P. Potaczek, Joanna Płonka, Martine Alhenc-Gelas, Anetta Undas Tags: Letters to the Editors-in-Chief Source Type: research
The Clinical Implications of ADAMTS13 Function: The Perspectives of Haemostaseologists
This article reviews the literature in these conditions.
Source: Thrombosis Research - September 19, 2013 Category: Hematology Authors: Savita Rangarajan, Craig Kessler, Louis Aledort Tags: Mini-Reviews Source Type: research
Time trends in pulmonary embolism: A matter of age and gender
Venous thromboembolism (VTE) is the third most common cardiovascular disease . Pulmonary embolism (PE) is potentially lethal and is the most serious manifestation of VTE . Notably, PE is the leading preventable cause of death in hospitalized patients , and is the third most common cardiovascular cause of death after myocardial infarction and stroke in Western world . Risk factors for VTE and PE include old age, surgery, immobilization, trauma, fractures, cancer, pregnancy, puerperium, oral contraceptive pill (OCP) use, and hormone replacement therapy (HRT) . Genetic factors are also important in VTE risk and family history...
Source: Thrombosis Research - June 24, 2013 Category: Hematology Authors: Bengt Zöller Tags: Editorials Source Type: research
Allogeneic bone marrow mesenchymal stem cells transplantation for stabilizing and repairing of atherosclerotic ruptured plaque
Abstract: Introduction: There have been no satisfactory therapies on stabilizing and repairing ruptured plagues nowadays, which are the fundamental causes of acute coronary syndrome (ACS) and stroke. The aim of this study was to investigate the therapeutic potential of bone marrow mesenchymal stem cells (MSCs) in stabilizing and repairing ruptured plaques.Materials and Methods: 28 male New Zealand rabbits were randomly divided into 2 groups after establishment of atherosclerotic disrupted plaque model by liquid nitrogen frostbite: MSCs transplantation group and control group. MSCs were isolated, cultured in vitro, and labe...
Source: Thrombosis Research - April 25, 2013 Category: Hematology Authors: Shun-Miao Fang, Da-Yong Du, Yun-Tian Li, Xing-Li Ge, Peng-Tao Qin, Qing-Hua Zhang, Yang Liu Tags: Platelets and Cell Biology Source Type: research
A low-volume, single pass in-vitro system of high shear thrombosis in a stenosis
Conclusions: Occlusive thrombus blocks the collagen-coated lumen with millions of platelets using human whole, heparinized blood. Rapid Platelet Accumulation rates in human blood are 4.5±2.4μm3/μm2/min (n=21). There is an initial lag time of 7.4±3.8min (n=21) before the onset of large scale thrombosis. The rates of platelet accumulation in vitro are consistent with the clinical timescale of coronary or carotid artery occlusion. Porcine blood has a faster accumulation rate of 9.6±6.1μm3/μm2/min (n=7, p
Source: Thrombosis Research - March 27, 2013 Category: Hematology Authors: Andrea N. Para, David N. Ku Tags: Coagulation and Fibrinolysis Source Type: research
Anticoagulation management in patients with mechanical heart valves having pacemaker or defibrillator insertion
Conclusion: We found a low risk for stroke in the absence of postoperative bridging. For patients with device replacement surgery reversal of the anticoagulant effect at the time of procedure might reduce the risk for pocket hematoma, but this requires prospective evaluation including the risk of thromboembolism.
Source: Thrombosis Research - January 31, 2013 Category: Hematology Authors: S. Schulman, J. Schoenberg, S. Divakara Menon, A.C. Spyropoulos, J.S. Healey, J.W. Eikelboom Tags: Clinical Studies Source Type: research
Inverse association between serum lipoprotein(a) and cerebral hemorrhage in the Japanese population
This study investigated the association between Lp(a) and the incidence of stroke and/or its subtypes in the general Japanese population.Materials and Methods: This population-based prospective cohort study included 10,494 community-dwelling participants (4,030 males/6,464 females). The incidence of stroke and its subtypes was the primary outcome. The subjects were divided into tertiles based on their Lp(a) levels, and the risk of all stroke and stroke subtypes was examined using Cox's proportional hazard model.Results: A total of 393 subjects (199 males and 194 females) with stroke were identified during a follow-up durat...
Source: Thrombosis Research - December 26, 2012 Category: Hematology Authors: Shizukiyo Ishikawa, Kazuhiko Kotani, Kazuomi Kario, Kazunori Kayaba, Tadao Gotoh, Yosikazu Nakamura, Eiji Kajii, the Jichi Medical School (JMS) cohort study group Tags: Clinical Studies Source Type: research
