A low-volume, single pass in-vitro system of high shear thrombosis in a stenosis

Conclusions: Occlusive thrombus blocks the collagen-coated lumen with millions of platelets using human whole, heparinized blood. Rapid Platelet Accumulation rates in human blood are 4.5±2.4μm3/μm2/min (n=21). There is an initial lag time of 7.4±3.8min (n=21) before the onset of large scale thrombosis. The rates of platelet accumulation in vitro are consistent with the clinical timescale of coronary or carotid artery occlusion. Porcine blood has a faster accumulation rate of 9.6±6.1μm3/μm2/min (n=7, p
Source: Thrombosis Research - Category: Hematology Authors: Tags: Coagulation and Fibrinolysis Source Type: research