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Source: Thrombosis Research
Condition: Thrombosis
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Total 219 results found since Jan 2013.
Specific risk scores for specific purposes: Use CHADS-VASc for assessing stroke risk, and use HAS-BLED for assessing bleeding risk in atrial fibrillation
Source: Thrombosis Research - June 10, 2014 Category: Hematology Authors: Mikhail S. Dzeshka, Gregory Y.H. Lip Source Type: research
Cost-effectiveness of Apixaban versus Warfarin and Aspirin in Sweden for Stroke Prevention in Patients with Atrial Fibrillation
Source: Thrombosis Research - May 26, 2014 Category: Hematology Authors: Tereza Lanitis, Thitima Kongnakorn, Lena Jacobson, Anna De Geer Source Type: research
D-dimer relates positively with increased blood pressure in black South Africans: The SABPA study
Conclusion: The black population had a more prothrombotic profile, with higher levels of coagulation markers and inhibited fibrinolysis, than the white study participants. The positive association between blood pressure and elevated D-dimer in the blacks may contribute to the high prevalence of hypertension and related increased cardiovascular and cerebrovascular risk in this group.
Source: Thrombosis Research - April 8, 2014 Category: Hematology Authors: Leandi Lammertyn, Aletta E. Schutte, Marlien Pieters, Rudolph Schutte Tags: Coagulation and Fibrinolysis Source Type: research
Mechanical heart valve prosthesis and warfarin – Treatment quality and prognosis
Conclusion: Patients with a lower warfarin treatment quality measured by TTR have a higher risk of complications such as severe bleeding or death. A TTR of 83% or higher at the individual level should be obtained for best outcome.
Source: Thrombosis Research - March 18, 2014 Category: Hematology Authors: Bartosz Grzymala-Lubanski, Ashkan Labaf, Erling Englund, Peter J. Svensson, Anders Själander Tags: Clinical Studies Source Type: research
Cost-effectiveness of dabigatran etexilate for the prevention of stroke and systemic embolism in atrial fibrillation in Taiwan
Abstract: Background: Economic evaluation of dabigatran, a new anti-antithrombotic agent, is done mostly in Western countries. It remains to be seen whether dabigatran will be cost effective in a practice environment where warfarin is significantly underused and the costs of both warfarin and international normalized ration INR monitoring are cheap.Methods: We performed a cost-effectiveness analysis with a Markov model to evaluate the value of dabigatran to prevent stroke and systemic embolism in patients with atrial fibrillation (AF) in Taiwan. Dabigatran was given through sequential dosing, where patients
Source: Thrombosis Research - March 17, 2014 Category: Hematology Authors: Chia-Hsien Chang, Yea-Huei Kao Yang, Jyh-Hong Chen, Li-Jen Lin Tags: Clinical Studies Source Type: research
Should women suffering from migraine with aura be screened for biological thrombophilia?: Results from a cross-sectional French study
Conclusion: FVL or FIIL mutations were more likely among patients suffering from MA. Whether biological thrombophilia screening should be systematically performed in women suffering from MA remains to be determined.
Source: Thrombosis Research - February 18, 2014 Category: Hematology Authors: L. Maitrot-Mantelet, M.H. Horellou, H. Massiou, J. Conard, A. Gompel, G. Plu-Bureau Tags: Clinical Studies Source Type: research
MC-002 exhibits positive effects against platelets aggregation and endothelial dysfunction through thromboxane A2 inhibition
In conclusion, MC-002 exerted antiplatelet aggregation effect through TXA2 inhibition and relieved inflammatory injury of endothelial cells through NF-κB signal pathway.
Source: Thrombosis Research - February 12, 2014 Category: Hematology Authors: Weirong Fang, Jie Wei, Dan Han, Xi Chen, Guangwei He, Qiang Wu, Shaoxing Chu, Yunman Li Tags: Platelets and cell biology Source Type: research
Possible limitations of using the HAS-BLED bleeding score in real life settings
Atrial fibrillation (AF) is the most prevalent sustained arrhythmia associated with a fivefold to sevenfold increased risk of ischemic stroke. Current recommendations are to consider oral anticoagulation (OAC) for all AF patients with a CHA2DS2VASc score of 1 or higher . In conjunction with the CHA2DS2VASc score, the HAS-BLED bleeding score is recommended for use when weighing the risk of thrombosis against the risk of bleeding . Although HAS-BLED is an objective and easily remembered scoring system, I have found that it is prone to misinterpretation by end-users.
Source: Thrombosis Research - February 12, 2014 Category: Hematology Authors: Sadi Gulec Tags: Editorials Source Type: research
Ensuring medication adherence with direct oral anticoagulant drugs: Lessons from adherence with vitamin K antagonists (VKAs)
Abstract: Medication adherence (taking drugs properly) is uncommon among patients on warfarin. Poor adherence to warfarin leads to an increase in adverse medical events, including stroke in atrial fibrillation (AF). Factors related to patients, physicians and the health system account for poor adherence. Direct oral anticoagulants (DOACs) are easier to use than warfarin, with fewer drug and food interactions and no need for routine blood monitoring. A proper use of DOACs may reduce the risk of stroke in AF. However, in clinical settings where no laboratory monitoring is needed, a poor medication adherence is common and may...
Source: Thrombosis Research - February 12, 2014 Category: Hematology Authors: Alessandro Di Minno, Gaia Spadarella, Antonella Tufano, Domenico Prisco, Giovanni Di Minno Tags: Mini-Reviews Source Type: research
Comparing patient-level and site-level anticoagulation control as predictors of adverse events
Conclusion: iTTR significantly predicted risk of major hemorrhage, ischemic stroke, and all-cause mortality. cTTR was a weak predictor of all-cause mortality. Though cTTR may be a better target for site-level quality improvement efforts, iTTR may be a more suitable measure for use in comparative effectiveness research.
Source: Thrombosis Research - February 6, 2014 Category: Hematology Authors: Ramon S. Cancino, Elaine M. Hylek, Joel I. Reisman, Adam J. Rose Tags: Coagulation and Fibrinolysis Source Type: research
CHADS2, CHA2DS2-VASc and HAS-BLED as predictors of outcome in patients with atrial fibrillation undergoing percutaneous coronary intervention
Conclusions: High CHA2DS2-VASc score was the best predictor of thrombotic outcomes after PCI in a high risk AF population. High mHAS-BLED score was not predictive of bleeding events. More accurate, simple risk scores are needed.
Source: Thrombosis Research - January 24, 2014 Category: Hematology Authors: Marja K. Puurunen, Tuomas Kiviniemi, Axel Schlitt, Andrea Rubboli, Britta Dietrich, Pasi Karjalainen, Kai Nyman, Matti Niemelä, Gregory Y.H. Lip, K.E. Juhani Airaksinen Tags: Clinical Studies Source Type: research
Influence of the β-fibrinogen-455G/A polymorphism on development of ischemic stroke and coronary heart disease
Conclusion: Our meta-analysis suggests that the FGB-455G/A polymorphism contributes to susceptibility to IS and CHD.
Source: Thrombosis Research - January 21, 2014 Category: Hematology Authors: Lian Gu, Wenhui Liu, Yan Yan, Li Su, Guangliang Wu, Baoyun Liang, Jinjing Tan, Guihua Huang Tags: Clinical Studies Source Type: research
Clopidogrel High-on-Treatment Platelet Reactivity in Acute Ischemic Stroke Patients
Conclusions: Clopidogrel-HTPR was found in 44% of the patients with acute ischemic stroke. Besides time-dependency of the clopidogrel effect, major risk factors for clopidogrel-HTPR were diabetes mellitus and higher HbA1c values. Further investigations are required to analyse if a function test guided strategy has the potential to optimize the antiplatelet therapy of acute stroke patients.
Source: Thrombosis Research - January 9, 2014 Category: Hematology Authors: Saskia H. Meves, Kay D. Schröder, Heinz G. Endres, Christos Krogias, Jan C. Krüger, Horst Neubauer Tags: Platelets and cell biology Source Type: research
Risk factors for arterial thrombosis in antiphospholipid syndrome
Conclusions: Among APS patients those with ACL IgG antibodies, having livedo reticularis, and suffering from hypertension an hypercholesterolemia are at the increased risk of arterial thrombosis.
Source: Thrombosis Research - December 9, 2013 Category: Hematology Authors: Aleksandra Matyja-Bednarczyk, Jakub Swadźba, Teresa Iwaniec, Marek Sanak, Sylwia Dziedzina, Adam Ćmiel, Jacek Musiał Tags: Clinical Studies Source Type: research
Differences in Thrombotic Risk Factors in Black and White Women with Adverse Pregnancy Outcome
Conclusions: Thrombotic risk factors differ significantly in white and black women with adverse pregnancy outcomes. Such differences highlight the importance of considering race separately when assessing thrombotic risk factors for adverse pregnancy outcomes.
Source: Thrombosis Research - November 18, 2013 Category: Hematology Authors: Claire S. Philipp, Ambarina S. Faiz, Michele G. Beckman, Althea Grant, Paula L. Bockenstedt, John A. Heit, Andra H. James, Roshni Kulkarni, Marilyn J. Manco-Johnson, Stephan Moll, Thomas L. Ortel Tags: Coagulation and Fibrinolysis Source Type: research
