Stroke RSS Page 8

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Source: Thrombosis Research
Condition: Thrombosis

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Total 219 results found since Jan 2013.

Cancer diagnosis as a risk factor of ischemic stroke in atrial fibrillation patients with low stroke risk score
Introduction: Atrial fibrillation (AF) is a well known risk factor of ischemic stroke (IS). Patients categorized as low risk according to stroke risk scores are not routinely recommended anticoagulation prophylaxis. Cancer is known to increase the risk of IS, but it is not clear to what extent cancer is a risk factor of IS in AF patients with low stroke risk score.
Source: Thrombosis Research - April 1, 2018 Category: Hematology Authors: A. Atterman, B. Gigante, K. Asplund, S. Aspberg Tags: PO-25 Source Type: research

Antidotes for the direct oral anticoagulants: What news?
The direct oral anticoagulants (DOACs) are recommended as the first-choice anticoagulants for both stroke prevention in patients with non-valvular atrial fibrillation and the treatment and secondary prevention of venous thromboembolism. DOACs cause bleeding, albeit less than warfarin. Most bleeding complications can be controlled by general reversal strategies and supportive care. However, in case of life-threatening bleeding, or when urgent invasive procedures are needed, a more rapid and thorough reversal may be required.
Source: Thrombosis Research - April 1, 2018 Category: Hematology Authors: S. Galliazzo, M.P. Donadini, W. Ageno Tags: Full Length Article Source Type: research

The effect of dabigatran on thrombin generation and coagulation assays in rabbit and human plasma
Dabigatran etexilate is widely used for stroke prevention in the patients with atrial fibrillation. The anticoagulation activity of dabigatran is not necessary monitored in routine clinical practice. We aimed to study the effect of dabigatran on thrombin generation (TG) and coagulation assays in rabbit and human plasma.
Source: Thrombosis Research - March 14, 2018 Category: Hematology Authors: Chi Zhang, Peizhe Zhang, Hongxia Li, Lianhua Han, Lei Zhang, Lei Zhang, Xiangjun Yang Tags: Full Length Article Source Type: research

Cancer-associated ischemic stroke: A retrospective multicentre cohort study
The association between stroke and cancer is well-known but insufficiently investigated. Aim of this multicentre retrospective cohort study was to estimate the prevalence of cancer-associated ischemic stroke, describe clinical outcomes in patients with cancer-associated ischemic stroke and investigate independent factors associated with active cancer.
Source: Thrombosis Research - March 14, 2018 Category: Hematology Authors: Stefano Grazioli, Maurizio Paciaroni, Giancarlo Agnelli, Monica Acciarresi, Andrea Alberti, Cataldo D'Amore, Valeria Caso, Michele Venti, Luigina Guasti, Walter Ageno, Alessandro Squizzato Tags: Full Length Article Source Type: research

Red cell distribution width as a predictor of 1-year survival in ischemic stroke patients treated with intravenous thrombolysis
Red cell distribution width (RDW) has been found to be a prognostic marker in vascular diseases. Increased RDW predicted mortality and outcome after ischemic stroke however, the underlying mechanisms are unclear. Our study aimed to clarify the relation of RDW with stroke severity and 1-year survival.
Source: Thrombosis Research - February 6, 2018 Category: Hematology Authors: Jo ão Pinho, Sofia Alexandra Marques, Eduardo Freitas, José Araújo, Mariana Taveira, José Nuno Alves, Carla Ferreira Tags: Full Length Article Source Type: research

CREM-transgene mice: A step towards understanding thrombogenesis in atrial fibrillation
Thrombo-embolic stroke is one of the most consequential complications of atrial fibrillation. One of the first decisions made when managing patients with this condition is estimating the thrombo-embolic risk and initiating appropriate therapy to lower this risk [1]. Several clinical risk factors have been associated with thrombo-embolization in atrial fibrillation, including age, hypertension, diabetes, heart failure, vascular disease and others. The predictive accuracy of clinical parameter based models for stroke prediction in AF has been modest [2], as the mechanistic explanation linking clinical risk factors to thrombu...
Source: Thrombosis Research - December 27, 2017 Category: Hematology Authors: Nazem Akoum Tags: Editorial Source Type: research

Outpatient therapy for acute symptomatic pulmonary embolism diagnosed in the emergency department: Time to improve the evidence base
Pulmonary embolism (PE) remains a worldwide major public health issue [1 –4]. After myocardial infarction and stroke, PE is the third most common cause of vascular death. In addition, PE is the leading preventable cause of death in hospitalized patients [2]. Treatment of PE costs over 19 billion dollars annually in the USA [3], and more than 50% of that expenditure rel ates to the cost of in-patient care [4]. The initial decision to admit the patient diagnosed with acute symptomatic PE in the emergency department (ED) to the hospital or to treat the patient at home therefore has significant patient care and public health implications.
Source: Thrombosis Research - November 25, 2017 Category: Hematology Authors: David Jim énez, Roger D. Yusen Tags: Editorial Source Type: research

Predicted risk of stroke and bleeding and use of oral anticoagulants in atrial fibrillation: Danish nationwide temporal trends 2011 –2016
We used Danish nationwide registries to examine temporal trends in the predicted stroke and bleeding risks (mean CHA2DS2-VASc and HAS-BLED scores per year, respectively) as well as the combination of selected stroke and bleeding risk factors per year among atrial fibrillation (AF) patients initiated for the first time between 2011 and 2016 on vitamin K antagonists (VKAs), dabigatran, rivaroxaban, or apixaban.
Source: Thrombosis Research - October 16, 2017 Category: Hematology Authors: Alexandar Dukanovic, Laila Staerk, Emil Loldrup Fosb øl, Kasper Gadsbøll, Gunnar Hilmar Gislason, Jonas Bjerring Olesen Tags: Full Length Article Source Type: research

Plasma let-7i and miR-15a expression are associated with the effect of recombinant tissue plasminogen activator treatment in acute ischemic stroke patients
Circulating microRNAs (miRNAs) have been reported as diagnosis biomarkers and predictors in acute ischemic stroke (AIS). However, how the expression of circulating miRNAs changes after recombinant tissue plasminogen activator (rt-PA) treatment in AIS patients is still unknown.
Source: Thrombosis Research - September 5, 2017 Category: Hematology Authors: Wei Xiang, Canhui Tian, Jingru Lin, Xiaohui Wu, Guanlai Pang, Liang Zhou, Suyue Pan, Zhen Deng Tags: Full Length Article Source Type: research

Ischemic stroke rates decline in patients with atrial fibrillation as anticoagulants uptake improves: A Swedish cohort study
The impact of the increased anticoagulants uptake on incidence rate of ischemic stroke is largely unknown. We assessed time trends in rates of ischemic stroke in patients with incident atrial fibrillation (AF) diagnosed between 2011 and 2013.
Source: Thrombosis Research - August 10, 2017 Category: Hematology Authors: Natalia Mochalina, Nazim Isma, Peter J. Svensson, Anders Sj älander, Maj Carlsson, Tord Juhlin, Mattias Wieloch Tags: Full Length Article Source Type: research

Outcomes of an online pharmacist-managed anticoagulation clinic for individuals on warfarin therapy living in rural communities
Warfarin is one of the oral anticoagulants used for the prevention of stroke in patients with atrial fibrillation and mechanical heart valves or the treatment of venous thromboembolism [1]. However, warfarin therapy is challenging not only because this drug is known to have a narrow therapeutic range and carry a risk of bleeding but also because it can be influenced by certain patient variables and potential drug –drug, drug–food, and drug–herb interactions. In Chinese patients, warfarin therapy is especially challenging because Chinese patients are more sensitive than Caucasians to the anticoagulant effect of warfar...
Source: Thrombosis Research - July 20, 2017 Category: Hematology Authors: Jinhua Zhang, Maobai Liu, Qiang Chen, Jianmei Wu, Hua Cao Tags: Letter to the Editors-in-Chief Source Type: research

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