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Source: Thrombosis Research
Condition: Thrombosis
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Total 219 results found since Jan 2013.
Impact of stroke on survival in patients with cancer
Thromboembolic events, including venous thromboembolism (VTE) and arterial thromboembolism (ATE), are significant concerns for patients with cancer as they can interrupt or delay essential cancer treatments and worsen outcomes [1]. Previous studies have suggested that VTE is associated with an increased risk of mortality in patients with cancer [2 –5]. Meanwhile, few studies have investigated the relationship between ATE and outcomes in patients with cancer. Grilz et al. assessed the effect of ATE on 2-year survival in such patients and reported that ATE was associated with a 3.2-fold increased risk of all-cause mortality [6].
Source: Thrombosis Research - January 6, 2023 Category: Hematology Authors: Yasufumi Gon, Tsutomu Sasaki, Tomohiro Kawano, Shuhei Okazaki, Kenichi Todo, Toshihiro Takeda, Yasushi Matsumura, Hideki Mochizuki Tags: Letter to the Editors-in-Chief Source Type: research
Endovascular thrombectomy or bridging therapy in minor ischemic stroke with large vessel occlusion
Whether direct endovascular thrombectomy (EVT) is non-inferior to bridging therapy (intravenous thrombolysis [IVT] followed by EVT) in minor acute ischemic stroke due to large vessel occlusions (AIS-LVO) is not clear. Therefore, this study aimed to assess whether direct EVT is non-inferior to bridging therapy in minor AIS-LVO.
Source: Thrombosis Research - September 25, 2022 Category: Hematology Authors: Wen-Jun Tu, Yicheng Xu, Yakun Liu, Jichen Du, Jizong Zhao Source Type: research
Cancer and stroke: What do we know and where do we go?
Cancer is an increasingly recognized cause for ischemic stroke, with recent acknowledgement of cancer-related stroke as an emerging stroke subtype with unique pathophysiologic mechanisms. In addition, cancer-related stroke may differ from stroke in the general population as cancer patients may not receive guideline-recommended stroke care, and the occurrence of stroke may also preclude patients from receiving optimal cancer treatments. Due to the high degree of morbidity and mortality associated with both conditions, understanding the relationship between stroke and cancer is crucial.
Source: Thrombosis Research - September 16, 2022 Category: Hematology Authors: Ronda Lun, Deborah Siegal, Tim Ramsay, Dar Dowlatshahi Source Type: research
Age and composition of the thrombus retrieved by mechanical thrombectomy from patients with acute ischemic stroke are associated with revascularization and clinical outcomes
Understanding the composition of stroke thrombi retrieved by mechanical thrombectomy is essential to clarify the pathogenesis of stroke. However, it is difficult to evaluate thrombus composition precisely and objectively. Immunohistochemical staining was used to evaluate thrombus composition and age.
Source: Thrombosis Research - September 6, 2022 Category: Hematology Authors: Hisao Shimizu, Kinta Hatakeyama, Kozue Saito, Ryogo Shobatake, Nobuyuki Takahashi, Jun Deguchi, Hidemori Tokunaga, Keiji Shimada, Ichiro Nakagawa, Kaoru Myochin, Kazuya Sakai, Masayuki Kubo, Atsushi Yamashita, Chiho Obayashi, Kazuma Sugie, Masanori Matsum Tags: Full Length Article Source Type: research
The long haul COVID-19 arterial thrombosis
The presence of a coexisting hypercoagulable state associated with Covid-19 infection has gained attention and several studies have already described acute limb ischemia (ALI) and peripheral arterial disease in critically ill patients, as well as coronary artery disease and ischemic stroke as manifestations usually associated with respiratory distress. Actually no information is currently available on how long inflammation and thrombotic derangements can last after recovery from Covid-19 symptoms and which patients are prone to develop acute arterial thrombosis.
Source: Thrombosis Research - July 26, 2022 Category: Hematology Authors: Maria Pia Borrelli, Adelaide Buora, Paolo Frigatti Tags: Letter to the Editors-in-Chief Source Type: research
Effectiveness and safety of edoxaban therapy in daily-care patients with atrial fibrillation. Results from the DRESDEN NOAC REGISTRY
Edoxaban is a non-vitamin K dependent oral anticoagulant (NOAC) licensed for stroke prevention in atrial fibrillation (SPAF). Outcome data on clinical effectiveness and safety in routine care are increasing.
Source: Thrombosis Research - May 22, 2022 Category: Hematology Authors: Christina K öhler, Luise Tittl, Sandra Marten, Christiane Naue, Marianne Spindler, Laura Stannek, Kristina Fache, Jan Beyer-Westendorf Tags: Letter to the Editors-in-Chief Source Type: research
Low molecular weight heparin anti-Xa assays can identify patients with clinically important apixaban and rivaroxaban drug levels
Direct oral anticoagulants (DOACs) do not require routine coagulation monitoring but measuring plasma drug levels may be helpful in specific circumstances. For example, patients with DOAC drug levels below 30 to 50 ng/mL are unlikely to benefit from anticoagulant reversal strategies before an urgent medical procedure or to treat major bleeding [1] or may be suitable candidates for systemic thrombolysis in the setting of acute ischemic stroke [2].
Source: Thrombosis Research - May 12, 2022 Category: Hematology Authors: Siraj Mithoowani, Karen A. Moffat, Akash Gupta, Stephen A. Carlino, Mark A. Crowther Tags: Letter to the Editors-in-Chief Source Type: research
PO-11: Risk of major bleeding in cancer patients with ischemic stroke treated with thrombolysis
Source: Thrombosis Research - May 1, 2022 Category: Hematology Authors: N. Skajaa, K. Adelborg, F.S. Troelsen, C.H. Fuglsang, E. Horv áth-Puhó, H.T. Sørensen Tags: Posters Source Type: research
OC-12: Stroke and risk of cancer: a Danish population-based cohort study
Source: Thrombosis Research - May 1, 2022 Category: Hematology Authors: N. Skajaa, K. Veres, F.S. Troelsen, J.D. Petersen, K. Adelborg, H.T. S ørensen Tags: Oral Communications Source Type: research
Coagulation factors XI and XII as possible targets for anticoagulant therapy
In this review, we give an overview over observational and experimental studies supporting factors XI and XII as targets for anticoagulant therapy. The majority of observational studies on FXI report low concentrations of FXI to be protective against ischemic stroke and venous thrombosis. There is also extensive evidence from experimental and animal studies supporting FXI inhibition as a target for anticoagulant therapy, alone or in combination with other antithrombotic treatments. Four Phase 2 clinical trials on patients undergoing total knee arthroplasty showed non-inferiority or superiority of FXI inhibition compared to...
Source: Thrombosis Research - April 23, 2022 Category: Hematology Authors: Karsten Engseth Kluge, Ingebj ørg Seljeflot, Harald Arnesen, Torstein Jensen, Sigrun Halvorsen, Ragnhild Helseth Source Type: research
Markers of NET formation and stroke risk in patients with atrial fibrillation: association with a prothrombotic state
Neutrophil extracellular traps (NETs) formation contributes to thrombosis but its role in atrial fibrillation (AF) is poorly explored. We investigated whether increased circulating NETs markers in relation to a hypercoagulable state can predispose to ischemic stroke in anticoagulated AF patients during long-term follow-up.
Source: Thrombosis Research - March 2, 2022 Category: Hematology Authors: Patrycja Mo łek, Michał Ząbczyk, Krzysztof P. Malinowski, Joanna Natorska, Anetta Undas Tags: Full Length Article Source Type: research
Diverse thrombus composition in thrombectomy stroke patients with longer time to recanalization time
Delayed time to recanalization is associated with reduced recanalization success of mechanical thrombectomy (MT) and thrombolysis in acute ischemic stroke (AIS). The reasons for this are unclear. We hypothesized that alterations in thrombus structure and composition could be responsible for this.
Source: Thrombosis Research - November 27, 2021 Category: Hematology Authors: Mehdi Abbasi, Jorge Arturo Larco, Madalina Oana Mereuta, Yang Liu, Se án Fitzgerald, Daying Dai, Ramanathan Kadirvel, Luis Savastano, David F. Kallmes, Waleed Brinjikji Source Type: research
Diverse thrombus composition in thrombectomy stroke patients with longer time to recanalization
Delayed time to recanalization is associated with reduced recanalization success of mechanical thrombectomy (MT) and thrombolysis in acute ischemic stroke (AIS). The reasons for this are unclear. We hypothesized that alterations in thrombus structure and composition could be responsible for this.
Source: Thrombosis Research - November 27, 2021 Category: Hematology Authors: Mehdi Abbasi, Jorge Arturo Larco, Madalina Oana Mereuta, Yang Liu, Se án Fitzgerald, Daying Dai, Ramanathan Kadirvel, Luis Savastano, David F. Kallmes, Waleed Brinjikji Source Type: research
To aPTT or not to aPTT: Evaluating the optimal monitoring strategy for unfractionated heparin
Anticoagulation is widely used in the inpatient setting for various indications for both surgical and medical patients including stroke prevention in non-valvular atrial fibrillation, prevention of venous thromboembolism in post-surgical patients, management of acute coronary syndromes, and treatment of acute thrombosis. For patients with acute thrombosis, anticoagulation is the key therapy to stabilize the thrombus, prevent extension, and to prevent development of new thrombosis while risk factors are present [1].
Source: Thrombosis Research - November 21, 2021 Category: Hematology Authors: Nathan T. Connell, Katelyn W. Sylvester Tags: Editorial Source Type: research
Fibrin to von Willebrand factor ratio in arterial thrombi is associated with plasma levels of inflammatory biomarkers and local abundance of extracellular DNA
The composition of thrombi determines their structure, mechanical stability, susceptibility to lysis, and consequently, the clinical outcome in coronary artery disease (CAD), acute ischemic stroke (AIS), and peripheral artery disease (PAD). Fibrin forms the primary matrix of thrombi intertwined with DNA, derived from neutrophil extracellular traps (NETs), and von Willebrand factor (VWF) bridging DNA and platelets. Here we examined the relative content of fibrin, DNA and VWF in thrombi and analyzed their interrelations and quantitative associations with systemic biomarkers of inflammation and clinical characteristics of the patients.
Source: Thrombosis Research - November 17, 2021 Category: Hematology Authors: Erzs ébet Tóth, László Beinrohr, István Gubucz, László Szabó, Kiril Tenekedjiev, Natalia Nikolova, Anikó I. Nagy, László Hidi, Péter Sótonyi, István Szikora, Béla Merkely, Krasimir Kolev Source Type: research
