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Source: Thrombosis Research
Condition: Thrombosis
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Total 219 results found since Jan 2013.
Multidisciplinary Stepwise Management Strategy for Acute Superior Mesenteric Venous Thrombosis: An Intestinal Stroke Center Experience
BackgroudAcute superior mesenteric venous thrombosis (ASMVT) is an uncommon but catastrophic abdominal vascular emergency with high rate of intestinal failure and mortality. The retrospective pilot study was performed to assess the effect of a multidisciplinary stepwise management strategy on survival and mesenteric recanalization in an integrated intestinal stroke center (ISC).
Source: Thrombosis Research - November 10, 2014 Category: Hematology Authors: Shuofei Yang, Xinxin Fan, Weiwei Ding, Baochen Liu, Jiaxiang Meng, Dandan Xu, Changsheng He, Wenkui Yu, Xingjiang Wu, Jieshou Li Tags: Regular article Source Type: research
Mesenteric Venous Thrombosis and the need for a specialized Intestinal Stroke Center
Mesenteric Venous Thrombosis (MVT) is an uncommon cause of Acute Mesenteric Ischemia (AMI) (9-16% among four types of AMI), typically affecting the superior mesenteric vein and more rarely the inferior mesenteric vein [1–3].
Source: Thrombosis Research - November 6, 2014 Category: Hematology Authors: Raffaele Serra, Stefano de Franciscis Tags: Editorial Source Type: research
VASP phosphorylation and genetic polymorphism for clopidogrel resistance in Chinese patients with non-cardioembolic ischemic stroke
Clopidogrel resistance(CR)is found in non-cardioembolic ischemic stroke (NCIS) patients. However, it is still largely unknown how to identify CR in NCIS patients by laboratory and genetic characteristics.
Source: Thrombosis Research - October 10, 2014 Category: Hematology Authors: Shijun Zhang, Xinqiang Lai, Wenxian Li, Zhen Jing, Zhilin Xiong, Anding Xu, Yiwen Ruan, Li'an Huang Tags: Regular Article Source Type: research
Thrombosis: A major contributor to global disease burden
Thrombosis is a common pathology underlying ischemic heart disease, ischemic stroke, and venous thromboembolism (VTE). The Global Burden of Disease Study 2010 (GBD 2010) documented that ischemic heart disease and stroke collectively caused one in four deaths worldwide. GBD 2010 did not report data for VTE as a cause of death and disability. We performed a systematic review of the literature on the global disease burden due to VTE in low, middle and high income countries. Studies from Western Europe, North America, Australia, and Southern Latin America (Argentina) yielded consistent results with annual incidences ranging fr...
Source: Thrombosis Research - October 10, 2014 Category: Hematology Authors: ISTH Steering Committee for World Thrombosis Day Tags: Review Article Source Type: research
Apixaban exerts anti-inflammatory effects in mesangial cells by blocking thrombin/protease-activated receptor-1 system
Atrial fibrillation (AF) is most frequent arrhythmia in patients with chronic kidney disease (CKD) [1,2]. Since diabetes and hypertension are risk components of CHADS2 score and also risk factors for CKD, CKD could affect cardiovascular outcomes in patients with AF [2–5]. Indeed, several papers have shown that renal dysfunction increases the risk of thromboembolic events, stroke and all-cause mortality in AF patients [2–5]. In randomized trials of AF patients with stage III CKD, novel oral anticoagulant, dabigatran 150mg twice daily was superior to warfarin for stroke prevention, while apixaban was superior in regard t...
Source: Thrombosis Research - September 25, 2014 Category: Hematology Authors: Yuji Ishibashi, Takanori Matsui, Sho-ichi Yamagishi Tags: Letter to the Editor-in-Chief Source Type: research
Anti-apoptotic role of sonic hedgehog on blood platelets
Sonic hedgehog (Shh) is an essential morphogen involved in vertebrate organogenesis. Perturbation of Hh signaling is associated with pathological consequences like tumor formation and chronic lung fibrosis. Platelets are highly sensitive circulating blood cells responsible for hemostasis, while hyperactivity of these cells lead to morbidities like ischemic heart diseases and stroke. Despite being terminally differentiated cells with life span of 10-12 days, platelets have recently been shown to respond to Wnt ligand, another developmental signal similar to Shh.
Source: Thrombosis Research - September 25, 2014 Category: Hematology Authors: Sharda Kumari, Susheel N. Chaurasia, Kailash Kumar, Debabrata Dash Tags: Regular Article Source Type: research
Patent foramen ovale increases the risk of acute ischemic stroke in patients with acute pulmonary embolism leading to right ventricular dysfunction
Patent foramen ovale (PFO) is an established risk factor for ischemic stroke. Since acute right ventricular dysfunction (RVD) observed in patients with PE can lead to right-to-left inter-atrial shunt via PFO, we hypothesized that PFO is a risk factor for ischemic stroke in PE with significant right ventricular dysfunction.
Source: Thrombosis Research - September 18, 2014 Category: Hematology Authors: Sylwia Goliszek, Małgorzata Wiśniewska, Katarzyna Kurnicka, Barbara Lichodziejewska, Michał Ciurzyński, Maciej Kostrubiec, Marek Gołębiowski, Marek Babiuch, Marzanna Paczynska, Marcin Koć, Piotr Palczewski, Anna Wyzgał, Piotr Pruszczyk Tags: Regular Article Source Type: research
New Method of Thrombus Preparation Using a Fluid Model for Evaluation of Thrombectomy Devices in a Swine Model
The objective of this study was to explore a new method of thrombus preparation with fluid model (FM) for assessment of thrombectomy devices used in the recanalization of acute ischemic stroke.
Source: Thrombosis Research - August 22, 2014 Category: Hematology Authors: Qiuji Shao, Liangfu Zhu, Tianxiao Li, Li Li, Dujuan Li, Jiaqiang Zhang, Wei Ren, Liheng Wu Source Type: research
New method of thrombus preparation using a fluid model for evaluation of thrombectomy devices in a swine model
The objective of this study was to explore a new method of thrombus preparation with fluid model (FM) for assessment of thrombectomy devices used in the recanalization of acute ischemic stroke.
Source: Thrombosis Research - August 22, 2014 Category: Hematology Authors: Qiuji Shao, Liangfu Zhu, Tianxiao Li, Li Li, Dujuan Li, Jiaqiang Zhang, Wei Ren, Liheng Wu Tags: Regular Article Source Type: research
Ex vivo reversal of the anticoagulant effects of edoxaban
This study evaluated the effect of two prohemostatic agents, recombinant factor VIIa (rFVIIa) and factor VIII inhibitor bypass activity (FEIBA), on the anticoagulatory effects of supratherapeutic concentrations of edoxaban in human whole blood ex vivo.
Source: Thrombosis Research - August 7, 2014 Category: Hematology Authors: Abdel-Baset Halim, Meyer M. Samama, Jeanne Mendell Source Type: research
Erythropoiesis-stimulating agents and thrombotic events in dialysis patients
Erythropoiesis-stimulating agents (ESA) have been associated with a higher cardiovascular event and mortality rate in dialysis patients. The ESA-associated risk of arterial thrombotic events is mainly based on composite endpoints of anemia-correction trials targeting high hemoglobin levels. The ESA-associated risk of venous thromboembolism (VTE) has not been studied in dialysis patients yet. We therefore aimed to determine the association between ESA use and dose with ischemic stroke, myocardial infarction (MI) and VTE.
Source: Thrombosis Research - August 1, 2014 Category: Hematology Authors: Marit M. Suttorp, Tiny Hoekstra, Gürbey Ocak, Anouk T.N. van Diepen, Ilka Ott, Moshe Mittelman, Ton J. Rabelink, Raymond T. Krediet, Friedo W. Dekker Source Type: research
On the monitoring of dabigatran treatment in “real life” patients with atrial fibrillation
The oral direct thrombin inhibitor dabigatran is increasingly used to prevent thromboembolic stroke in patients with atrial fibrillation (AF). Routine laboratory monitoring is currently not recommended, but measurements of dabigatran and/or its effect are desirable in certain situations. We studied dabigatran exposure and compared different tests for monitoring of dabigatran in a real-life cohort of AF patients.
Source: Thrombosis Research - July 6, 2014 Category: Hematology Authors: Mika Skeppholm, Paul Hjemdahl, Jovan P. Antovic, Josephine Muhrbeck, Jaak Eintrei, Yuko Rönquist-Nii, Anton Pohanka, Olof Beck, Rickard E. Malmström Tags: Regular Article Source Type: research
Blood genomic profiling in extracranial- and intracranial atherosclerosis in ischemic stroke patients
Source: Thrombosis Research - July 6, 2014 Category: Hematology Authors: Han-Bin Lee, Yoon Kim, Hanna Yoo, Ji-Min Lee, Yu-Kyung Kim, Nam-Keun Kim, Jin-Kyeoung Kim, Seung-Hun Oh Source Type: research
Lysability of fibrin clots is a potential new determinant of stroke risk in atrial fibrillation
Source: Thrombosis Research - July 5, 2014 Category: Hematology Authors: Jane Skov, Johannes J. Sidelmann, Else-Marie Bladbjerg, Jørgen Jespersen, Jørgen Gram Source Type: research
