Platelet reactivity in patients carrying the e-NOS G894T polymorphism after a loading dose of aspirin plus clopidogrel

Nitric oxide (NO) plays an important role in the modulation of platelet reactivity through platelet recruitment, activation and aggregation. NO is produced by the endothelial NO synthase (eNOS) that is expressed not only in the endothelium but also in platelets [1]. G894T single nucleotide polymorphism of eNOS gene results in the substitution of glutamic acid at codon 298 by aspartic acid. This substitution in the protein sequence is responsible of lower enzyme activity, i.e. lower NO production, and it has been associated with coronary spasm, atherosclerosis, myocardial infarction, and stroke [2 –6].
Source: Thrombosis Research - Category: Hematology Authors: Tags: Letter to the Editors-in-Chief Source Type: research