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Cardiovascular and Neuronal Consequences of Thyroid Hormones Alterations in the Ischemic Stroke
Metabolites. 2022 Dec 23;13(1):22. doi: 10.3390/metabo13010022.ABSTRACTIschemic stroke is one of the leading global causes of neurological morbidity and decease. Its etiology depends on multiple events such as cardiac embolism, brain capillaries occlusion and atherosclerosis, which ultimately culminate in blood flow interruption, incurring hypoxia and nutrient deprivation. Thyroid hormones (THs) are pleiotropic modulators of several metabolic pathways, and critically influence different aspects of tissues development. The brain is a key TH target tissue and both hypo- and hyperthyroidism, during embryonic and adult life, a...
Source: Atherosclerosis - January 21, 2023 Category: Cardiology Authors: Melania Murolo Olivia Di Vincenzo Annunziata Gaetana Cicatiello Luca Scalfi Monica Dentice Source Type: research

Benefit of Anticoagulation Therapy in Hyperthyroidism‐Related Atrial Fibrillation
ConclusionsPatients with hyperthyroidism‐related AF are at high risk of stroke (3.9% per year). Warfarin confers stroke prevention in patients with CHA2DS2‐VASc ≥1 and non–self‐limiting AF. Overall stroke risk was lower in hyperthyroid non–self‐limiting AF patients compared with nonhyperthyroid counterparts.
Source: Clinical Cardiology - July 1, 2015 Category: Cardiology Authors: Pak‐Hei Chan, Jojo Hai, Chun‐Yip Yeung, Gregory Y.H. Lip, Karen Siu‐Ling Lam, Hung‐Fat Tse, Chung‐Wah Siu Tags: Clinical Investigations Source Type: research

Antihypertensive treatment and risk of atrial fibrillation: a nationwide study
Conclusion Use of ACEis and ARBs compared with β-blockers and diuretics associates with a reduced risk of atrial fibrillation, but not stroke, within the limitations of a retrospective study reporting associations. This suggests that controlling activation of the renin-angiotensin system in addition to controlling blood pressure is associated with a reduced risk of atrial fibrillation.
Source: European Heart Journal - May 7, 2014 Category: Cardiology Authors: Marott, S. C. W., Nielsen, S. F., Benn, M., Nordestgaard, B. G. Tags: Hypertension Source Type: research

Should antithrombotic therapy be different in patients with atrial fibrillation and a so-called temporary cause and especially after an acute coronary syndrome?
ConclusionIn patients with a possibly TCAF, use of oral anticoagulation was independently associated with a better prognosis. Antiplatelet therapy use was also independently associated with a better prognosis when patients with TCAF had ACS.
Source: Archives of Cardiovascular Diseases Supplements - December 25, 2018 Category: Cardiology Source Type: research

Prevalence and predisposing conditions for atrial fibrillation in hospitalised patients with hypertension.
CONCLUSIONS: Among hospitalised patients with hypertension, AF is present in a significant proportion of patients. Conditions predisposing to this arrhythmia in hypertensives include HF, IHD, thyroid diseases, and previous myocardial infarction. There was no evidence that diabetes, abnormal lipid profile, and impaired kidney function affected AF rate among patients with hypertension. PMID: 23788340 [PubMed - as supplied by publisher]
Source: Polish Heart Journal - June 22, 2013 Category: Cardiology Authors: Gorczyca-Michta I, Wożakowska-Kapłon B, Tomasik E Tags: Kardiol Pol Source Type: research

Prevalence and spectrum of PITX2c mutations associated with familial atrial fibrillation
Atrial fibrillation (AF) is the most common form of cardiac arrhythmia seen in clinical practice, accounting for approximately one-third of hospitalizations for heart rhythm disorders. The prevalence of AF is estimated to be 1% in the general population and increases markedly with advancing age, rising from about 0.5% of people in their fifties to nearly 10% of the octogenarians . AF is associated with substantial morbidity and mortality. It confers a 5-fold increased risk of stroke and a double risk of death . AF generally occurs secondary to various cardiac and systemic disorders, including hypertension, coronary artery ...
Source: International Journal of Cardiology - April 22, 2013 Category: Cardiology Authors: Yi-Qing Yang, Ying-Jia Xu, Ruo-Gu Li, Xin-Kai Qu, Wei-Yi Fang, Xu Liu Tags: Letters to the Editor Source Type: research

Serum nitrate and nitrite are associated with the prevalence of various chronic diseases except cancer.
CONCLUSION: Thus, fasting concentrations of NOx in serum can be an important diagnostic parameter characteristic for specific chronic diseases. PMID: 26899180 [PubMed - as supplied by publisher]
Source: International Angiology - February 25, 2016 Category: Cardiology Tags: Int Angiol Source Type: research

Clinical and etiological study of atrial fibrillation in elderly in upper Assam
In this study the majority of the patients (78), i.e., 22.03% were in the age group of 61–70 years. Majority of the patients were female (58.19%). Males comprised of 41.81%. The common symptoms of atrial fibrillation in the patients were palpitation 85.31% and breathlessness 82.77%. Next common symptoms were fatigue 73.16%, PND 70.06% and swelling of dependant parts 68.93% respectively. Giddiness 57.91% and orthopnea 53.67% were the next common presenting symptoms. Chest pain was the presenting complaint in 22.32% cases and limb weakness or stroke in 7.34% cases. Involuntary movements 3.95% and sleep apnea 1.97% were amo...
Source: Journal of Indian College of Cardiology - February 9, 2017 Category: Cardiology Source Type: research

Thyroid Function Within the Normal Range, Subclinical Hypothyroidism and the Risk of Atrial Fibrillation.
Conclusions -In euthyroid individuals, higher circulating fT4 levels, but not TSH levels, are associated with increased risk of incident AF. PMID: 29061566 [PubMed - as supplied by publisher]
Source: Circulation - October 23, 2017 Category: Cardiology Authors: Baumgartner C, da Costa BR, Collet TH, Feller M, Floriani C, Bauer DC, Cappola AR, Heckbert SR, Ceresini G, Gussekloo J, den Elzen WPJ, Peeters RP, Luben R, Völzke H, Dörr M, Walsh JP, Bremner A, Iacoviello M, Macfarlane P, Heeringa J, Stott DJ, Westend Tags: Circulation Source Type: research

Subclinical thyroid dysfunction and cardiovascular diseases: 2016 update
AbstractSubclinical thyroid dysfunction comprises subclinical hypothyroidism (SHypo), defined as elevated thyroid-stimulating hormone (TSH) by normal free thyroxine (FT4), and subclinical hyperthyroidism (SHyper) with decreased or undetectable TSH and normal FT4. Up to 10% of the elderly have SHypo, which is usually asymptomatic. Individual participant data (IPD) analyses of prospective cohort studies from the international Thyroid Studies Collaboration show that SHypo is associated with increased coronary heart disease (CHD) mortality [hazard ratio (HR) 1,58 for TSH ≥ 10 mIU/L, 95% CI 1.10–2.27), as well as increased ...
Source: European Heart Journal - February 27, 2017 Category: Cardiology Source Type: research

Relation between Thyroid Function and Mortality in patients with Chronic Heart Failure
Thyroid hormones have genomic and non-genomic effects on the cardiovascular system. They increase stroke volume, heart rate, and reduce systemic vascular resistance. (1) Overt thyroid disease (both hypothyroidism and hyperthyroidism) can cause heart failure. (2) Subclinical thyroid dysfunction is present when serum thyroid-stimulating hormone level (TSH) is outside the reference range, but free thyroxine (fT4), and total or free triiodothyronine level (T3) are normal. (3) In subclinical hyperthyroidism, TSH is low, and in subclinical hypothyroidism, TSH is raised.
Source: The American Journal of Cardiology - October 24, 2020 Category: Cardiology Authors: Nathan A. Samuel, Joseph J. Cuthbert, Oliver I. Brown, Syed Kazmi, John G.F. Cleland, Alan S. Rigby, Andrew L. Clark Source Type: research

Prediction of short-term atrial fibrillation risk using primary care electronic health records
Conclusions FIND-AF, a machine learning algorithm applicable at scale in routinely collected primary care data, identifies people at higher risk of short-term AF.
Source: Heart - June 26, 2023 Category: Cardiology Authors: Nadarajah, R., Wu, J., Hogg, D., Raveendra, K., Nakao, Y. M., Nakao, K., Arbel, R., Haim, M., Zahger, D., Parry, J., Bates, C., Cowan, C., Gale, C. P. Tags: Open access, Editor's choice Arrhythmias and sudden death Source Type: research