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Condition: Hemorrhagic Stroke
Procedure: Perfusion

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Total 533 results found since Jan 2013.

Flat-Panel Computed Tomography (DYNA-CT) in Neuroradiology. From High-Resolution Imaging of Implants to One-Stop-Shopping for Acute Stroke
Abstract Originally aimed at improving standard radiography by providing higher absorption efficiency and a wider dynamic range, flat-panel detector technology has meanwhile got widely accepted in the neuroradiological community. Especially flat-panel detector computed tomography (FD-CT) using rotational C-arm mounted flat-panel detector technology is capable of volumetric imaging with a high spatial resolution. By providing CT-like images of the brain within the angio suite, FD-CT is able to rapidly visualize hemorrhage and may thus improve complication management without the need of patient transfer. As “Angio...
Source: Clinical Neuroradiology - June 20, 2015 Category: Neurology Source Type: research

Arteriovenous shunts and capillary blush as an early sign of basal ganglia infarction after successful mechanical intra-arterial thrombectomy in ischaemic stroke
Conclusions Both angiographic signs seem to predict the irreversible damage of tissue in the basal ganglia reliably despite successful recanalization of the middle cerebral artery in patients with ischaemic stroke. Key Points • Evaluation of success in neurointerventional procedures is mainly based on recanalization rates. • Two separate angiographic signs can predict infarction immediately after proximal MCA recanalization. • Combining both signs increases their specificity.
Source: European Radiology - September 7, 2015 Category: Radiology Source Type: research

Computed tomography perfusion-based thrombolysis in wake-up stroke
Abstract Wake-up stroke (WUS) patients are typically excluded from reperfusion treatment, as the time of symptoms onset is unknown. The purpose of this study is to evaluate the clinical outcome and safety of intravenous thrombolysis with rt-PA in patients with WUS eligible for therapy using computed tomography perfusion criteria (CTP), compared to patients treated with rt-PA within 4.5 h of symptoms onset (non-WUS). This is an experimental, open-label trial, controlled against the best therapy currently in use. Primary endpoints were functional independence after 3 months [modified Rankin scale (mRS) ≤ 1] ...
Source: Internal and Emergency Medicine - September 14, 2015 Category: Emergency Medicine Source Type: research

Effects of Induced Hypertension on Cerebral Perfusion in Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage: A Randomized Clinical Trial Brief Reports
Conclusions— Change in overall CBF did not differ to a statistically significant extent between the groups. Based on our results, 225 to 250 patients per group are needed to find a statistically significant difference in change in overall CBF between induced hypertension and no hypertension. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT0161323.
Source: Stroke - October 26, 2015 Category: Neurology Authors: Gathier, C. S., Dankbaar, J. W., van der Jagt, M., Verweij, B. H., Oldenbeuving, A. W., Rinkel, G. J. E., van den Bergh, W. M., Slooter, A. J. C., for the HIMALAIA Study Group, Algra, Beute, Coert, Dammers, Dippel, Dirven, Horn, Muller, Kesecioglu, van Ko Tags: Clinical Studies, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Computerized tomography and Magnetic Resonance Imaging, Other Stroke Treatment - Medical Brief Reports Source Type: research

Effect of recombinant plasminogen activator timing on thrombolysis in a novel rat embolic stroke model
Publication date: Available online 30 March 2016 Source:Pharmacological Research Author(s): Yinzhong Ma, Li Li, Ziran Niu, Junke Song, Yihuang Lin, Huifang Zhang, Guanhua Du The treatment of acute ischemic stroke (AIS) using thrombolysis with recombinant tissue-plasminogen activator (rtPA, alteplase) is limited by its narrow time window and the risk of hemorrhage. Recombinant plasminogen activator (rPA, reteplase) has been used clinically on coronary artery thrombosis and acute myocardial infarction. It is necessary to induce strokes experimentally as a means of validating the rPA timing on patients with AIS. Howe...
Source: Pharmacological Research - March 30, 2016 Category: Drugs & Pharmacology Source Type: research

Feasibility of Near Infra-Red Spectroscopy in Blood Pressure Management Following Thrombectomy for Acute Large Vessel Occlusion Ischemic Stroke (P5.045)
Conclusions:NIRS monitoring is a feasible method of evaluating patients undergoing thrombectomy for LVO ischemic strokes. This study is continuing to enroll patients to help determine whether NIRS monitoring may help determine better blood pressure targets following thrombectomy.Disclosure: Dr. Saini has nothing to disclose. Dr. Mahapatra has nothing to disclose. Dr. O'Phelan has nothing to disclose. Dr. Kottapally has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Saini, V., Mahapatra, A., OPhelan, K., Kottapally, M. Tags: Neurocritical Care: Ischemic Injury Source Type: research

Induced Hypertension for Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage Clinical Sciences
Conclusions—Before this trial, the effectiveness of induced hypertension for DCI in aneurysmal subarachnoid hemorrhage patients was unknown because current literature consists only of uncontrolled case series. The results from our premature halted trial do not add any evidence to support induced hypertension and show that this treatment can lead to serious adverse events.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT01613235.
Source: Stroke - December 22, 2017 Category: Neurology Authors: Celine S. Gathier, Walter M. van den Bergh, Mathieu van der Jagt, Bon H. Verweiȷ, Jan Willem Dankbaar, Marcella C. Muller, Annemarie W. Oldenbeuving, Gabriel J.E. Rinkel, Arȷen J.C. Slooter, for the HIMALAIA Study Group* Tags: Treatment, Quality and Outcomes, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Rationale and design of a randomized trial of early intensive blood pressure lowering on cerebral perfusion parameters in thrombolysed acute ischemic stroke patients
Conclusion: This randomized study will provide important information about the physiological effects of BP reduction on cerebral perfusion after intravenous thrombolysis in AIS.
Source: Medicine - October 1, 2018 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Leukoaraiosis is associated with poor outcomes after successful recanalization for large vessel occlusion stroke
ConclusionsLA severity may be associated with poor outcomes after successful recanalization for ischemic stroke with anterior large vessel occlusion.
Source: Neurological Sciences - January 5, 2019 Category: Neurology Source Type: research

Cerebral Hemodynamic Evaluation After Cerebral Recanalization Therapy for Acute Ischemic Stroke
Cerebral recanalization therapy, either intravenous thrombolysis or mechanical thrombectomy, improves the outcomes in patients with acute ischemic stroke by restoring the cerebral perfusion of the ischemic penumbra. Cerebral hemodynamic evaluation after recanalization therapy, can help identify patients with high risks of reperfusion-associated complications. Among the various hemodynamic modalities, magnetic resonance imaging, computed tomography perfusion, and transcranial Doppler sonography are the most commonly used. Poststroke hypoperfusion is associated with infarct expansion, while hyperperfusion, which once was con...
Source: Frontiers in Neurology - July 2, 2019 Category: Neurology Source Type: research

A perfusion territory shift attributable solely to the secondary collaterals in moyamoya patients: a potential risk factor for preoperative hemorrhagic stroke revealed by t-ASL and 3D-TOF-MRA.
CONCLUSIONS: t-ASL could reveal comprehensive MMD cerebral blood perfusion and the vivid perfusion territory shifts fed by the unilateral ICA and ECA and bilateral VAs in a noninvasive, straightforward, nonradioactive, and nonenhanced manner. 3D-TOF-MRA could subdivide t-ASL perfusion territory shifts according to their shunt arteries. A perfusion territory shift attributable to the secondary collaterals is a potential independent risk factor for preoperative hemorrhage in MMD patients. A perfusion territory shift fed by the primary collaterals may not have a strong effect on preoperative hemorrhage in MMD patients. These ...
Source: Journal of Neurosurgery - August 8, 2019 Category: Neurosurgery Authors: Gao XY, Li Q, Li JR, Zhou Q, Qu JX, Yao ZW Tags: J Neurosurg Source Type: research

What is the Role of Hyperosmolar Therapy in Hemispheric Stroke Patients?
AbstractThe role of hyperosmolar therapy (HT) in large hemispheric ischemic or hemorrhagic strokes remains a controversial issue. Past and current stroke guidelines state that it represents a reasonable therapeutic measure for patients with either neurological deterioration or intracranial pressure (ICP) elevations documented by ICP monitoring. However, the lack of evidence for a clear effect of this therapy on radiological tissue shifts and clinical outcomes produces uncertainty with respect to the appropriateness of its implementation and duration in the context of radiological mass effect without clinical correlates of ...
Source: Neurocritical Care - March 19, 2020 Category: Neurology Source Type: research

Pituitary apoplexy causing acute ischemic stroke: Which treatment should be given priority.
Conclusion: Direct compression of ICA is rare complication of pituitary apoplexy, which caused cerebral ischemia. Conventional angiography should be necessary for accurate diagnosis and prompt surgical decompression should be the treatment of choice. PMID: 32494388 [PubMed]
Source: Surgical Neurology International - June 6, 2020 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

Computed tomography perfusion in patients of stroke with left ventricular assist device
AbstractLeft ventricular assist devices (LVAD) are widely applied for patients with severe heart failure as a bridge to heart transplantation as well as destination therapy. Patients with implanted LVAD have an increased risk of cerebral thrombosis and computed tomographic perfusion (CTP) has the potential to be performed for early diagnosis and treatment of acute ischemic stroke (AIS), including interventional thrombectomy. Here, we report our series of CTP examination in patients having suspected AIS after LVAD implantation. We retrospectively investigated 33 contrast-enhanced CTPs from January 2017 to December 2018 whic...
Source: Heart and Vessels - August 9, 2020 Category: Cardiology Source Type: research

The Relationship Between Penumbral Tissue and Blood-Brain Barrier Disruption in Acute Stroke Patients Presenting in an Extended Time Window
Conclusions: Patients presenting in an extended time window with a favorable penumbral profile for treatment have less severe BBB disruption. Up to a third of patients who currently go untreated could be considered for enrollment in a clinical trial of thrombolysis in an extended time window.
Source: Frontiers in Neurology - December 8, 2020 Category: Neurology Source Type: research