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Condition: Hemorrhagic Stroke
Procedure: Perfusion

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Total 533 results found since Jan 2013.

Early Insulin Glycemic Control Combined With tPA Thrombolysis Reduces Acute Brain Tissue Damages in a Focal Embolic Stroke Model of Diabetic Rats Brief Reports
Conclusions— Early insulin glycemic control may be beneficial in combination with tPA thrombolysis for ischemic stroke with diabetes mellitus or poststroke hyperglycemia.
Source: Stroke - December 24, 2012 Category: Neurology Authors: Fan, X., Ning, M., Lo, E. H., Wang, X. Tags: Animal models of human disease, Type 1 diabetes, Acute Cerebral Infarction, Embolic stroke, Emergency treatment of Stroke, Thrombolysis Brief Reports Source Type: research

Remote Ischemic Perconditioning as an Adjunct Therapy to Thrombolysis in Patients With Acute Ischemic Stroke: A Randomized Trial Clinical Sciences
Conclusions— Although the overall results were neutral, a tissue survival analysis suggests that prehospital rPerC may have immediate neuroprotective effects. Future clinical trials should take such immediate effects, and their duration, into account. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00975962.
Source: Stroke - December 23, 2013 Category: Neurology Authors: Hougaard, K. D., Hjort, N., Zeidler, D., Sorensen, L., Norgaard, A., Hansen, T. M., von Weitzel-Mudersbach, P., Simonsen, C. Z., Damgaard, D., Gottrup, H., Svendsen, K., Rasmussen, P. V., Ribe, L. R., Mikkelsen, I. K., Nagenthiraja, K., Cho, T.-H., Reding Tags: Emergency treatment of Stroke, Computerized tomography and Magnetic Resonance Imaging, Neuroprotectors, Thrombolysis Clinical Sciences Source Type: research

Prevalence of Imaging Biomarkers to Guide the Planning of Acute Stroke Reperfusion Trials Brief Report
Conclusions—As part of the feasibility analysis in stroke clinical trials, this analysis and the resulting tables can help investigators determine sample size and the number needed to screen.
Source: Stroke - May 22, 2017 Category: Neurology Authors: Bin Jiang, Robyn L. Ball, Patrik Michel, Tudor Jovin, Manisha Desai, Ashraf Eskandari, Zack Naqvi, Max Wintermark Tags: Computerized Tomography (CT), Ischemic Stroke Brief Reports Source Type: research

Neurorestorative Responses to Delayed Human Mesenchymal Stromal Cells Treatment of Stroke in Type 2 Diabetic Rats Basic Sciences
Conclusions—In T2DM stroke rats, delayed hMSC treatment significantly improves neurological functional outcome and increases neurorestorative effects and M2 macrophage polarization. Increasing brain platelet-derived growth factor expression may contribute to hMSC-induced neurorestoration.
Source: Stroke - October 23, 2016 Category: Neurology Authors: Yan, T., Venkat, P., Chopp, M., Zacharek, A., Ning, R., Roberts, C., Zhang, Y., Lu, M., Chen, J. Tags: Cell Therapy, Stem Cells, Diabetes, Type 2, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Induction of Cooling With a Passive Head and Neck Cooling Device: Effects on Brain Temperature After Stroke Clinical Sciences
Conclusions— Although the decrease of brain temperature after Sovika cooling device application was statistically significant, we doubt clinical relevance of this rather limited effect (–0.36°C). Moreover, the transient increases of blood pressure and ICP warrant caution.
Source: Stroke - February 25, 2013 Category: Neurology Authors: Poli, S., Purrucker, J., Priglinger, M., Diedler, J., Sykora, M., Popp, E., Steiner, T., Veltkamp, R., Bosel, J., Rupp, A., Hacke, W., Hametner, C. Tags: Cerebrovascular disease/stroke, CPR and emergency cardiac care, Other Treatment, Emergency treatment of Stroke Clinical Sciences Source Type: research

Permeability Surface of Deep Middle Cerebral Artery Territory on Computed Tomographic Perfusion Predicts Hemorrhagic Transformation After Stroke Clinical Sciences
Conclusions—Increased PS can predict HT of deep MCA territory after recanalization therapy for cerebral proximal large-vessel occlusion. Proximal MCA-M1 complete occlusion and distal internal carotid artery occlusion in conjunction with poor collaterals elevate deep MCA territory PS.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Qiao Li, Xinyi Gao, Zhenwei Yao, Xiaoyuan Feng, Huijin He, Jing Xue, Peiyi Gao, Lumeng Yang, Xin Cheng, Weijian Chen, Yunjun Yang Tags: Angiography, Computerized Tomography (CT), Blood-Brain Barrier, Ischemic Stroke Original Contributions Source Type: research

Identification of Reversible Disruption of the Human Blood-Brain Barrier Following Acute Ischemia Brief Reports
Conclusions— This study demonstrates that diffuse, mild BBB disruption in the acutely ischemic human brain is reversible with reperfusion. This study also confirms prior findings that focal severe BBB disruption confers an increased risk of hemorrhagic transformation in patients treated with intravenous tissue-type plasminogen activator.
Source: Stroke - August 21, 2016 Category: Neurology Authors: Simpkins, A. N., Dias, C., Leigh, R., on behalf of the National Institutes of Health Natural History of Stroke Investigators, Benson, Hsia, Latour, Luby, Lynch, Merino, Nadareishvili, Warach Tags: Magnetic Resonance Imaging (MRI), Blood-Brain Barrier, Intracranial Hemorrhage, Ischemic Stroke Brief Reports Source Type: research

Worse stroke outcome in atrial fibrillation is explained by more severe hypoperfusion, infarct growth, and hemorrhagic transformation
ConclusionAtrial fibrillation is associated with greater volumes of more severe baseline hypoperfusion, leading to higher infarct growth, more frequent severe hemorrhagic transformation and worse stroke outcomes.
Source: International Journal of Stroke - March 12, 2013 Category: Neurology Authors: Hans T. H. Tu, Bruce C. V. Campbell, Soren Christensen, Patricia M. Desmond, Deidre A. De Silva, Mark W. Parsons, Leonid Churilov, Maarten G. Lansberg, Michael Mlynash, Jean‐Marc Olivot, Matus Straka, Roland Bammer, Gregory W. Albers, Geoffrey A. Donnan Tags: Research Source Type: research

Canadian Stroke Best Practice Recommendations: Hyperacute Stroke Care Guidelines, Update 2015
The 2015 update of the Canadian Stroke Best Practice Recommendations Hyperacute Stroke Care guideline highlights key elements involved in the initial assessment, stabilization, and treatment of patients with transient ischemic attack (TIA), ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, and acute venous sinus thrombosis. The most notable change in this 5th edition is the addition of new recommendations for the use of endovascular therapy for patients with acute ischemic stroke and proximal intracranial arterial occlusion. This includes an overview of the infrastructure and resources required ...
Source: International Journal of Stroke - July 6, 2015 Category: Neurology Authors: Leanne K. Casaubon, Jean‐Martin Boulanger, Dylan Blacquiere, Scott Boucher, Kyla Brown, Tom Goddard, Jacqueline Gordon, Myles Horton, Jeffrey Lalonde, Christian LaRivière, Pascale Lavoie, Paul Leslie, Jeanne McNeill, Bijoy K. Menon, Brian Moses, Melani Tags: Guidelines Source Type: research

Protocol for the perfusion and angiography imaging sub‐study of the Third International Stroke Trial (IST‐3) of alteplase treatment within six‐hours of acute ischemic stroke
RationaleIntravenous thrombolysis with recombinant tissue Plasminogen Activator improves outcomes in patients treated early after stroke but at the risk of causing intracranial hemorrhage. Restricting recombinant tissue Plasminogen Activator use to patients with evidence of still salvageable tissue, or with definite arterial occlusion, might help reduce risk, increase benefit and identify patients for treatment at late time windows. AimsTo determine if perfusion or angiographic imaging with computed tomography or magnetic resonance help identify patients who are more likely to benefit from recombinant tissue Plasminogen Ac...
Source: International Journal of Stroke - January 22, 2013 Category: Neurology Authors: Joanna M. Wardlaw, Rudiger Kummer, Trevor Carpenter, Mark Parsons, Richard I. Lindley, Geoff Cohen, Veronica Murray, Adam Kobayashi, Andre Peeters, Francesca Chappell, Peter A. G. Sandercock Tags: Protocols Source Type: research

Endovascular treatment beyond 24 hours from the onset of acute ischemic stroke: the Italian Registry of Endovascular Thrombectomy in Acute Stroke (IRETAS)
Conclusions These findings suggest that, in a real world setting, very late endovascular therapy is feasible in appropriately selected patients.
Source: Journal of NeuroInterventional Surgery - November 14, 2022 Category: Neurosurgery Authors: Casetta, I., Fainardi, E., Pracucci, G., Saia, V., Vallone, S., Zini, A., Bergui, M., Cerrato, P., Nappini, S., Nencini, P., Gasparotti, R., Saletti, A., Causin, F., Romano, D., Burdi, N., Giorgianni, A., Mangiafico, S., Toni, D., The Italian Registry of Tags: Ischemic stroke Source Type: research

Safety and Effectiveness of Endovascular Treatment after 6 Hours of Symptom Onset in Patients with Anterior Circulation Ischemic Stroke: A Matched Case Control Study
Conclusions: We did not observe any evidence of benefit in halting neurologic worsening or improving outcomes among patients undergoing endovascular treatment for treatment of an anterior circulation ischemic stroke after 6 hours of symptom onset. Strong evidence of both the safety and efficacy of emergent endovascular treatment when administered to patients with stroke in the anterior circulation is needed.
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2012 Category: Neurology Authors: Adnan I. Qureshi, Jefferson T. Miley, Saqib A. Chaudhry, Edouard Semaan, Gustavo J. Rodriguez, M.Fareed K. Suri, Harold P. Adams Tags: Original Articles Source Type: research

Correlation between cerebral blood volume values and outcomes in endovascular therapy for acute ischemic stroke
Conclusions We found that cortical CBV loss is predictive of poor clinical outcomes, whereas basal ganglia CBV loss is predictive of hemorrhagic transformation but without translation into poor clinical outcomes. Our study findings support published results of baseline preintervention CBV as a predictor of outcomes in patients undergoing intra-arterial stroke therapies.
Source: Journal of NeuroInterventional Surgery - September 13, 2015 Category: Neurosurgery Authors: Mokin, M., Morr, S., Fanous, A. A., Shallwani, H., Natarajan, S. K., Levy, E. I., Snyder, K. V., Siddiqui, A. H. Tags: Ischemic stroke Source Type: research

Prediction of Poststroke Hemorrhagic Transformation Using Computed Tomography Perfusion Clinical Sciences
Conclusions— Tmax >14 s was the CTP parameter most strongly associated with PH. This outperformed relative cerebral blood flow <30%, which closely equates to CTP estimates of ischemic core volume. Although ischemic core volume on CTP is useful in the pretreatment prediction of PH, severe hypoperfusion on Tmax is more strongly associated and may allow better prediction of the likely anatomic location of hemorrhage.
Source: Stroke - October 21, 2013 Category: Neurology Authors: Yassi, N., Parsons, M. W., Christensen, S., Sharma, G., Bivard, A., Donnan, G. A., Levi, C. R., Desmond, P. M., Davis, S. M., Campbell, B. C. V. Tags: Acute Cerebral Infarction, Emergency treatment of Stroke, Computerized tomography and Magnetic Resonance Imaging, Thrombolysis Clinical Sciences Source Type: research

Effects of Noninvasive Facial Nerve Stimulation in the Dog Middle Cerebral Artery Occlusion Model of Ischemic Stroke Basic Sciences
Conclusions— These results support the development and evaluation of a noninvasive facial nerve stimulator device as a treatment of ischemic stroke.
Source: Stroke - March 24, 2014 Category: Neurology Authors: Borsody, M. K., Yamada, C., Bielawski, D., Heaton, T., Castro Prado, F., Garcia, A., Azpiroz, J., Sacristan, E. Tags: Other Treatment Basic Sciences Source Type: research