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Condition: Hemorrhagic Stroke
Nutrition: Calcium

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Total 162 results found since Jan 2013.

Advances in the Development of Biomarkers for Poststroke Epilepsy
Biomed Res Int. 2021 Apr 17;2021:5567046. doi: 10.1155/2021/5567046. eCollection 2021.ABSTRACTStroke is the main cause of acquired epilepsy in elderly people. Poststroke epilepsy (PSE) not only affects functional recovery after stroke but also brings considerable social consequences. While some factors such as cortical involvement, hemorrhagic transformation, and stroke severity are associated with increased seizure risk, so far that remains controversial. In recent years, there are an increasing number of studies on potential biomarkers of PSE as tools for diagnosing and predicting epileptic seizures. Biomarkers such as i...
Source: Biomed Res - May 7, 2021 Category: Research Authors: Mengke Liang Liren Zhang Zhi Geng Source Type: research

Usability of serum annexin A7 as a biochemical marker of poor outcome and early neurological deterioration after acute primary intracerebral hemorrhage: A prospective cohort study
ConclusionSerum ANXA7 may represent a useful blood-derived biomarker for assessing the severity, END, and prognosis of ICH.
Source: Frontiers in Neurology - August 8, 2022 Category: Neurology Source Type: research

3D Ultrasonic Tissue Characterization for Asymptomatic Carotid Atherosclerosis
Carotid plaque histology has confirmed that intraplaque hemorrhage and enlarging lipid-cores are important determinants of plaque rupture and stroke. Noninvasive characterization of these features may identify individuals at risk for stroke. Two-dimensional (2D) longitudinal-sectional ultrasound images have been used to predict plaque histology, but a single slice provides limited information. Tissue-characterization from 3D ultrasound imaging may offer more comprehensive information. We developed a clinical 3D ultrasound protocol to quantify plaque composition (hemorrhage, lipid, calcium and fibromuscular tissue), measure...
Source: Journal of Vascular Surgery - August 22, 2014 Category: Surgery Authors: Khalid AlMuhanna, Murad Hossain, Limin Zhao, Gregory Kowalewski, Siddhartha Sikdar, Brajesh K. Lal Tags: Abstracts from the 2014 New England Society for Vascular Surgery/Eastern Vascular Society Joint Annual Meeting Source Type: research

Medtech approvals: FDA releases August 2015 PMAs
The FDA today released its list of the pre-market approvals it granted for medical devices in August 2015: Summary of PMA Originals & Supplements Approved Originals: 2 Supplements: 70 Summary of PMA Originals Under Review Total Under Review: 57 Total Active: 28 Total On Hold: 29 Summary of PMA Supplements Under Review Total Under Review: 569 Total Active: 422 Total On Hold: 147 Summary of All PMA Submissions Originals: 5 Supplements: 90 Summary of PMA Supplement PMA Approval/Denial Decision Times Number of Approvals: 70 Number of Denials: 0 Average Days Fr Receipt to Decision (Total Time): 229.0 FDA Time: 130...
Source: Mass Device - October 23, 2015 Category: Medical Equipment Authors: Brad Perriello Tags: Food & Drug Administration (FDA) Pre-Market Approval (PMA) Regulatory/Compliance Source Type: news

Hypertension Canada ’s 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults
Publication date: Available online 10 March 2017 Source:Canadian Journal of Cardiology Author(s): Alexander A. Leung, Stella S. Daskalopoulou, Kaberi Dasgupta, Kerry McBrien, Sonia Butalia, Kelly B. Zarnke, Kara Nerenberg, Kevin C. Harris, Meranda Nakhla, Lyne Cloutier, Mark Gelfer, Maxime Lamarre-Cliche, Alain Milot, Peter Bolli, Guy Tremblay, Donna McLean, Sheldon W. Tobe, Marcel Ruzicka, Kevin D. Burns, Michel Vallée, G. V. Ramesh Prasad, Steven E. Gryn, Ross D. Feldman, Peter Selby, Andrew Pipe CM, Ernesto L. Schiffrin, Philip A. McFarlane, Paul Oh, Robert A. Hegele, Milan Khara, Thomas W. Wilson, S. Brian Penner, El...
Source: Canadian Journal of Cardiology - March 9, 2017 Category: Cardiology Source Type: research

White Matter Injury in Early Brain Injury after Subarachnoid Hemorrhage.
Abstract Subarachnoid hemorrhage (SAH) is a major cause of high morbidity, disability, and mortality in the field of neurovascular disease. Most previous SAH studies have focused on improving cerebral blood flow, reducing cerebral vasospasm, reducing neuronal calcium overload, and other treatments. While these studies showed exciting findings in basic science, therapeutic strategies based on the findings have not significantly improved neurological outcomes in patients with SAH. Currently, the only drug proven to effectively reduce the neurological defects of SAH patients is nimodipine. Current advances in imaging...
Source: Cell Transplantation - November 16, 2018 Category: Cytology Authors: Pang J, Peng J, Yang P, Kuai L, Chen L, Zhang JH, Jiang Y Tags: Cell Transplant Source Type: research

Association between physical activity and sedentary behaviour on carotid atherosclerotic plaques: an epidemiological and histological study in 90 asymptomatic patients.
CONCLUSION: In this cross-sectional study of asymptomatic patients who underwent endarterectomy (i) higher reported PA, (ii) intensity of PA and (iii) lower reported SB were associated with lower prevalence of intraplaque haemorrhage. This could be a mechanism whereby PA protects against cerebrovascular disease (stroke) and death. PMID: 30842104 [PubMed - as supplied by publisher]
Source: British Journal of Sports Medicine - March 5, 2019 Category: Sports Medicine Authors: Mury P, Mura M, Della-Schiava N, Chanon S, Vieille-Marchiset A, Nicaise V, Chirico EN, Collet-Benzaquen D, Lermusiaux P, Connes P, Millon A, Pialoux V Tags: Br J Sports Med Source Type: research

Mediacalcosis in hemodialysis, predictors and prognosis
ConclusionMediacalcosis is a severe complication since it increases the risk of cardiovascular morbidity and mortality in hemodialysis patients, to this end, the individualization of entangled factors involved in its pathophysiology, will slow down or prevent its progression in the future.
Source: Archives of Cardiovascular Diseases Supplements - July 24, 2019 Category: Cardiology Source Type: research

Nimodipine Reappraised: An Old Drug With a Future.
Abstract Nimodipine is a dihydropyridine calcium channel antagonist that blocks the flux of extracellular calcium through L-type, voltage-gated calcium channels. While nimodipine is FDA-approved for the prevention and treatment of neurological deficits in patients with aneurysmal subarachnoid hemorrhage (aSAH), it affects myriad cell types throughout the body, and thus, likely has more complex mechanisms of action than simple inhibition of cerebral vasoconstriction. Newer understanding of the pathophysiology of delayed ischemic injury after a variety of acute neurologic injuries including aSAH, traumatic brain inj...
Source: Current Neuropharmacology - September 26, 2019 Category: Drugs & Pharmacology Authors: Carlson AP, Hänggi D, Macdonald RL, Shuttleworth CW Tags: Curr Neuropharmacol Source Type: research

Serum calcium channel subunit α2δ-1 concentrations and outcomes in patients with acute spontaneous intracerebral hemorrhage
CONCLUSIONS: Serum α2δ-1 subunit concentrations are intimately correlated with illness severity and are independently associated with poor 90-day outcome, substantializing serum α2δ-1 subunit as a potential prognostic biomarker for ICH.PMID:35007528 | DOI:10.1016/j.cca.2022.01.002
Source: International Journal of Clinical Chemistry - January 10, 2022 Category: Chemistry Authors: Hao Zhang Ze-Sheng Wu Jing-Quan Liu Huan Huang Source Type: research

Influence of Experimental Subarachnoid Hemorrhage on Nicotine-induced Contraction of the Rat Basilar Artery in Relation to Nicotinic Acetylcholine Receptors, Calcium, and Potassium Channels
Conclusions: Nicotine-induced contraction of the rat basilar artery involved the CNS nAChR subfamily, skeletal muscle nAChR subfamily, and L-type Ca2+ channel pathways. SAH did not affect any of the subfamilies of nAChR, but the Ca2+ channel was reduced and the adenosine triphosphate–sensitive K+ channel was enhanced by SAH.
Source: Journal of Stroke and Cerebrovascular Diseases - November 4, 2011 Category: Neurology Authors: Xu Ji, Aimin Wang, Cristina C. Trandafir, Kazuyoshi Kurahashi Tags: Original Articles Source Type: research

Influence of Experimental Subarachnoid Hemorrhage on Nicotine-induced Contraction of the Rat Basilar Artery in Relation to Arachidonic Acid Metabolites Signaling Pathway
Conclusions: One week after exposure to SAH, PLC, sPLA2, and COX-2 activity were enhanced and cPLA2 activity was inhibited. One hour after exposure to SAH, PLC activity was enhanced and cPLA2 and iPLA2 activity was inhibited. Such changes of inflammatory arachidonic acid metabolites by smoking after SAH may play important roles in fatal cerebral circulatory disorders, suggesting important implications for the etiology and pathogenesis of SAH.
Source: Journal of Stroke and Cerebrovascular Diseases - January 3, 2012 Category: Neurology Authors: Xu Ji, Aimin Wang, Cristina C. Trandafir, Kazuyoshi Kurahashi Tags: Original Articles Source Type: research

Plaque hemorrhage in carotid artery disease: Pathogenesis, clinical and biomechanical considerations
Abstract: Stroke remains the most prevalent disabling illness today, with internal carotid artery luminal stenosis due to atheroma formation responsible for the majority of ischemic cerebrovascular events. Severity of luminal stenosis continues to dictate both patient risk stratification and the likelihood of surgical intervention. But there is growing evidence to suggest that plaque morphology may help improve pre-existing risk stratification criteria. Plaque components such a fibrous tissue, lipid rich necrotic core and calcium have been well investigated but plaque hemorrhage (PH) has been somewhat overlooked. In this r...
Source: Journal of Biomechanics - February 3, 2014 Category: Biomedical Science Authors: Zhongzhao Teng, Umar Sadat, Adam J. Brown, Jonathan H. Gillard Source Type: research

The Relationship Between Nocturnal Blood Pressure and Hemorrhagic Stroke in Chinese Hypertensive Patients
To study the relationship between nocturnal blood pressure (BP) variation and spontaneous intracerebral hemorrhage (ICH) among Chinese hypertensive patients and its clinical significance, the authors retrospectively screened 371 patients with primary hypertension (189 patients with ICH, 182 patients without ICH) in Shanghai and analyzed their demographics, clinical information, nocturnal blood pressure variability and medication. Compared with the control group, the levels of blood glucose, triglycerides, and creatinine were significantly increased in the ICH group, along with a marked reduction in nocturnal BP drop (P<...
Source: The Journal of Clinical Hypertension - July 24, 2014 Category: Cardiology Authors: Jialan Sun, Wanlin Yang, Yang Zhu, Xiaohong Liu, Xin Wei, Baisong Wang, Jiuchang Zhong, Yi Fu Tags: Original Paper Source Type: research