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Condition: Glaucoma

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Total 129 results found since Jan 2013.

Associations of ophthalmic and systemic conditions with incident dementia in the UK Biobank
CONCLUSIONS: AMD, cataract and DRED but not glaucoma are associated with an increased risk of dementia. Individuals with both ophthalmic and systemic conditions are at higher risk of dementia compared with those with an ophthalmic or systemic condition only.PMID:34518160 | DOI:10.1136/bjophthalmol-2021-319508
Source: The British Journal of Ophthalmology - September 14, 2021 Category: Opthalmology Authors: Xianwen Shang Zhuoting Zhu Yu Huang Xueli Zhang Wei Wang Danli Shi Yu Jiang Xiaohong Yang Mingguang He Source Type: research

Identification of a New Genetic Mutation Associated With Peters Anomaly
Conclusions: PA might be associated with the mutation c.181_189delinsAGGTTTCCG; p.Gly61Arg in the COL4A1 gene. The COL4A1 gene encodes for collagen IVα1, an essential component of basal membranes, and mutations are associated with an increased risk for renal and cerebrovascular disorders and stroke. This should be considered when advising and monitoring patients.
Source: Cornea - February 17, 2021 Category: Opthalmology Tags: Case Report Source Type: research

Assessment of Cerebral Vasomotor Reactivity in Patients With Primary Open-angle Glaucoma and Ocular Hypertension Using the Breath-Holding Index
Précis: Patients with ocular hypertension (OHT) do not show impaired cerebral vasodilation responses to hypercapnia but patients with primary open-angle glaucoma (POAG) do. Impaired vasoreactivity in patients with POAG may have neuronal or vascular origins and increase stroke risk. Purpose: To investigate changes in cerebral blood flow and cerebral vasomotor reactivity using the breath-holding index in patients with POAG and OHT, to examine whether these parameters contribute to the risk of ischemic stroke. Methods: Thirty patients with POAG, 30 patients with OHT, and 30 age- and sex-matched healthy cont...
Source: Journal of Glaucoma - February 1, 2021 Category: Opthalmology Tags: Clinical Science: Original Studies Source Type: research

Low- and moderate-dose non-cancer effects of ionizing radiation in directly exposed individuals, especially circulatory and ocular diseases: a review of the epidemiology.
CONCLUSIONS: We document statistically significant excess risk of the major types of circulatory disease, specifically ischemic heart disease and stroke, in moderate- or low-dose exposed groups, with some not altogether consistent evidence suggesting dose response non-linearity, particularly for stroke. However, the patterns of risk reported are not straightforward. We also document evidence of excess risks at lower doses/dose-rates of posterior subcapsular and cortical cataract in the Chernobyl liquidators, US Radiologic Technologists and Russian Mayak nuclear workers, with fundamentally linear dose response. Nuclear cata...
Source: International Journal of Radiation Biology - January 22, 2021 Category: Radiology Tags: Int J Radiat Biol Source Type: research

How Good is Photoscreening For Young Children ’ s Vision Problems?
This study showed that not only was smartphone photoscreening feasible, but was quite good at screening for potential vision problems. Smartphone photoscreening has the advantages of being more ubiquitously available and thus children in almost any location can be screened. A study of photoscreening using a handheld digital photoscreener in primary care offices validated the technology showing an overall referral rate of 10% to an ophthalmologist with suspected astigmatism, anisometropia and strabismus being the most common reasons. The overall positive predictive rate was 0.60. “…[O]ver 60% of children referre...
Source: PediatricEducation.org - January 4, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Association between cognitive performance and self-reported glaucoma in middle-aged and older adults: a cross-sectional analysis of ELSA-Brasil.
Authors: Vidal KS, Suemoto CK, Moreno AB, Duncan B, Schmidt MI, Maestri M, Barreto SM, Lotufo PA, Bertola L, Bensenor IM, Brunoni AR Abstract Recent evidence suggests that glaucoma and Alzheimer's disease are neurodegenerative diseases sharing common pathophysiological and etiological features, although findings are inconclusive. We sought to investigate whether self-reported glaucoma patients without dementia present poorer cognitive performance, an issue that has been less investigated. We employed cross-sectional data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) and included participants â...
Source: Brazilian Journal of Medical and Biological Research - November 5, 2020 Category: Research Tags: Braz J Med Biol Res Source Type: research

Complement-Mediated Microglial Phagocytosis and Pathological Changes in the Development and Degeneration of the Visual System
The focus of this review is the role of complement-mediated phagocytosis in retinal and neurological diseases affecting the visual system. Complement activation products opsonize synaptic material on neurons for phagocytic removal, which is a normal physiological process during development, but a pathological process in several neurodegenerative diseases and conditions. We discuss the role of complement in the refinement and elimination of synapses in the retina and lateral geniculate nucleus, both during development and in disease states. How complement and aberrant phagocytosis promotes injury to the visual system is dis...
Source: Frontiers in Immunology - September 23, 2020 Category: Allergy & Immunology Source Type: research

IJERPH, Vol. 17, Pages 6808: An Artificial Neural Network Model for Assessing Frailty-Associated Factors in the Thai Population
In this study, general characteristics and health data were assessed using modified versions of Fried’s Frailty Phenotype (mFFP) and the Frail Non-Disabled (FiND) questionnaire (mFiND) to construct a Self-Organizing Map (SOM). Trained data, composed of the component planes of each variable, were visualized using 2-dimentional hexagonal grid maps. The relationship between the variables and the final SOM was then investigated. The SOM model using the modified FiND questionnaire showed a correct classification rate (%CC) of about 66% rather than the model responded to mFFP models. The SOM Discrimination Index (S...
Source: International Journal of Environmental Research and Public Health - September 17, 2020 Category: Environmental Health Authors: Nawapong Chumha Sujitra Funsueb Sila Kittiwachana Pimonpan Rattanapattanakul Peerasak Lerttrakarnnon Tags: Article Source Type: research

Inactive bowel movement and stroke are associated with increased risks of mild cognitive impairment among community-living Singapore elderly.
Abstract Mild cognitive impairment (MCI), as a preclinical phase of dementia, provides an invaluable time window for intervention. Besides several proposed modifiable risk factors, the associations of MCI with dietary habits and bowel movement are not well clarified. We thus conducted a cross-sectional study of community-living Singapore elderly and focused on the relationship of clinically diagnosed MCI with dietary habits and bowel movement frequencies. The multiple logistic regression results showed that frequent (≥4 days per week) fruit consumption (P = 0.004), active (≥4 days per week) bowel movement with...
Source: Aging - September 8, 2020 Category: Biomedical Science Authors: Huang KY, Tang XY, Yang L, Zhang ZY, Ye KX, Shen QF, Wang X, Zhu XH, Huang XW, Lu GD, Feng L Tags: Aging (Albany NY) Source Type: research

Automatic Grading of Retinal Blood Vessel in Deep Retinal Image Diagnosis
AbstractAutomatic grading of retinal blood vessels from fundus image can be a useful tool for diagnosis, planning and treatment of eye. Automatic diagnosis of retinal images for early detection of glaucoma, stroke, and blindness is emerging in intelligent health care system. The method primarily depends on various abnormal signs, such as area of hard exudates, area of blood vessels, bifurcation points, texture, and entropies. The development of an automated screening system based on vessel width, tortuosity, and vessel branching are also used for grading. However, the automated method that directly can come to a decision b...
Source: Journal of Medical Systems - August 31, 2020 Category: Information Technology Source Type: research

Identification of a mosaic activating mutation in GNA11 in atypical Sturge-Weber Syndrome
Sturge-Weber syndrome (Online Mendelian Inheritance in Man #185300) is a capillary malformation condition (Bichsel and Bischoff, 2019, Comi, 2015). Affected regions include the skin (typically with facial cutaneous vascular malformations called port-wine birthmarks), brain (often resulting in seizures, intellectual disability, and recurrent stroke-like episodes), and eye (often causing glaucoma). We (Shirley et al., 2013) and others (Frigerio et al., 2015, Nakashima et al., 2014) reported that 90% of individuals with SWS or nonsyndromic PWB have a mosaic, activating mutation in GNAQ, encoding G protein subunit alpha q (G αq).
Source: Journal of Investigative Dermatology - August 5, 2020 Category: Dermatology Authors: Jeremy Thorpe, Laurence P. Frelin, Meghan McCann, Carlos A. Pardo, Bernard A. Cohen, Anne M. Comi, Jonathan Pevsner Tags: Letters to the Editor Source Type: research

CDKN2B-AS1: An indispensable long non-coding RNA in multiple diseases.
CONCLUSIONS: Long non-coding RNA CDKN2B-AS1 likely serves as a promising therapeutic target or prognosis biomarker in multiple human diseases. PMID: 32767927 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - August 4, 2020 Category: Drugs & Pharmacology Authors: Song C, Qi Y, Zhang J, Guo C, Yuan C Tags: Curr Pharm Des Source Type: research

IJERPH, Vol. 17, Pages 3398: Prevalence of Comorbidities in Individuals Diagnosed and Undiagnosed with Alzheimer ’s Disease in León, Spain and a Proposal for Contingency Procedures to Follow in the Case of Emergencies Involving People with Alzheimer’s Disease
Conclusions: Some comorbidities were present in both the AD and control groups, while others were found in the AD group and not in the control group, and vice versa.
Source: International Journal of Environmental Research and Public Health - May 12, 2020 Category: Environmental Health Authors: Tortajada-Soler S ánchez-Valdeón Blanco-Nistal Ben ítez-Andrades Li ébana-Presa Bay ón-Darkistade Tags: Article Source Type: research