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Condition: Peripheral Vascular Disease (PVD)

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Total 2060 results found since Jan 2013.

Interaction Between Chromosome 2 and 3 Regulates Pulse Pressure in the Stroke-Prone Spontaneously Hypertensive Rat Genetics
In an F2 cross between stroke-prone spontaneously hypertensive (SHRSP) and Wistar Kyoto (WKY) rats, we previously identified blood pressure quantitative trait loci (QTL) on rat chromosome (RNO) 2 and a pulse pressure QTL on RNO3. The aims of this study were to confirm the QTL on RNO3 and to investigate interaction between RNO2 and RNO3 loci through the generation and phenotypic assessment of single RNO3 congenic (SP.WKYGla3a) and bicongenic (SP.WKYGla2a/3a) strains. Hemodynamic profiling, vascular function, and renal histology were examined in these newly generated strains along with the previously reported RNO2 congenic s...
Source: Hypertension - June 12, 2013 Category: Cardiology Authors: Koh-Tan, H. H. C., McBride, M. W., McClure, J. D., Beattie, E., Young, B., Dominiczak, A. F., Graham, D. Tags: Animal models of human disease, Peripheral vascular disease Genetics Source Type: research

The association of ankle‐brachial index with silent cerebral small vessel disease: results of the Atahualpa Project
ConclusionsIn this population‐based study conducted in rural Ecuador, apparently healthy individuals aged ≥60 years with ankle‐brachial index values ≤0·90 and ≥1·4 are almost four times more likely to have a silent lacunar infarct. Ankle‐brachial index screening might allow recognition of asymptomatic people who need further investigation and preventive therapy.
Source: International Journal of Stroke - January 12, 2015 Category: Neurology Authors: Oscar H. Del Brutto, Mark J. Sedler, Robertino M. Mera, Julio Lama, Jadry A. Gruen, Kelsie J. Phelan, Elizabeth H. Cusick, Mauricio Zambrano, David L. Brown Tags: Research Source Type: research

Clopidogrel Versus Aspirin in Patients with Recent Ischemic Stroke and Established Peripheral Artery Disease: An Economic Evaluation in a Chinese Setting
Conclusions The analysis suggests that clopidogrel for secondary prevention is cost effective for patients with either PAD or recent IS in a Chinese setting in comparison with aspirin.
Source: Clinical Drug Investigation - May 19, 2015 Category: Drugs & Pharmacology Source Type: research

Vascular comorbidities in younger people with dementia: a cross-sectional population-based study of 616 245 middle-aged people in Scotland
This study aims to determine the prevalence of vascular comorbidity in people aged <65 with dementia in comparison to the general population. Methods Analysis of routine clinical data from 314 (30%) general medical practices in Scotland. Results From an overall population of 616 245 individuals, 1061 cases of ‘all-cause’ dementia were identified (prevalence 172/100 000 population, 95% CI 161 to 182). The prevalence of dementia was higher in people with vascular morbidities, and prevalence progressively increased from 129/100 000 in people with no vascular comorbidity to 999/100 000 in p...
Source: Journal of Neurology, Neurosurgery and Psychiatry - August 13, 2015 Category: Neurosurgery Authors: Heath, C. A., Mercer, S. W., Guthrie, B. Tags: JNNP Patients' choice, Dementia, Stroke, Hypertension, Ischaemic heart disease, Memory disorders (psychiatry) Cognitive neurology Source Type: research

Predictors of intracranial cerebral artery stenosis in patients before cardiac surgery and its impact on perioperative and long-term stroke risk
Conclusion The occurrence of intracranial artery stenosis in CABG patients cannot be predicted by well-known atherosclerotic risk factors and seems not to be associated with perioperative stroke.
Source: Polish Journal of Neurology and Neurosurgery - January 19, 2016 Category: Neurosurgery Source Type: research

Coronary Heart Disease, Peripheral Arterial Disease, and Stroke in Familial Hypercholesterolaemia: Insights From the SAFEHEART Registry (Spanish Familial Hypercholesterolaemia Cohort Study).
CONCLUSIONS: The prevalence of ASCVD is higher, and the involvement of the arterial territories is different in FH patients when compared with their unaffected relatives. Age, male sex, increased body mass index, hypertension, type 2 diabetes mellitus, smoking habit, and lipoprotein(a) >50 mg/dL were independently associated to ASCVD. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT02693548. PMID: 27444203 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - July 20, 2016 Category: Cardiology Authors: Pérez de Isla L, Alonso R, Mata N, Saltijeral A, Muñiz O, Rubio-Marin P, Diaz-Diaz JL, Fuentes F, de Andrés R, Zambón D, Galiana J, Piedecausa M, Aguado R, Mosquera D, Vidal JI, Ruiz E, Manjón L, Mauri M, Padró T, Miramontes JP, Mata P, SAFEHEART In Tags: Arterioscler Thromb Vasc Biol Source Type: research

A Clinical Score for Predicting Atrial Fibrillation in Patients with Cryptogenic Stroke or Transient Ischemic Attack
Conclusions: Findings from this study support the strategy of looking longer and harder for AF in post-CS/TIA patients. The HAVOC score identifies different levels of AF risk and may be used to select patients for extended rhythm monitoring.Cardiology 2017;138:133-140
Source: Cardiology - June 27, 2017 Category: Cardiology Source Type: research

Bayer ’s Xarelto® significantly lowered the combined risk of stroke, cardiovascular death and heart attack in patients with chronic coronary or peripheral artery disease by 24% (for specialized target groups only)
Importantly, rivaroxaban vascular dose, 2.5 mg twice daily, plus aspirin 100 mg once daily showed an unprecedented 42% relative risk reduction in stroke and 22% in cardiovascular death compared with aspirin 100 mg once daily alone / Bleeding rates were low, and while major bleeding was increased, notably there was no significant increase in intracranial or fatal bleeding / This combination regimen demonstrated a substantial improvement in net clinical benefit of 20%
Source: Bayer Company News - August 27, 2017 Category: Pharmaceuticals Source Type: news

Rivaroxaban in the cardiovascular world: a direct anticoagulant useful to prevent stroke, and venous and arterial thromboembolism.
Authors: Seoane L, Cortés M, Aris Cancela ME, Furmento J, Baranchuk A, Conde D Abstract INTRODUCTION: Until recently, vitamin K antagonists were the only drugs available for long-term anticoagulation. The use of these drugs is laborious due to their variable pharmacokinetics and pharmacodynamics. The advent of direct oral anticoagulants has produced a paradigm shift due to their low incidence of drug interactions, their stable plasma levels and their lack of monitoring. Rivaroxaban, a factor Xa inhibitor, has been tested in different clinical scenarios and has proved to be effective and safe, even increasing the s...
Source: Expert Review of Cardiovascular Therapy - June 6, 2018 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Strong Correlation Of Stroke And Mortality With Low Bile Acid Output
Background and Aims: Hypercholesterolemia is a major risk factor for atherosclerosis which is a cornerstone of coronary artery disease (CAD), stroke, peripheral vascular disease, aortic aneurism and renal artery stenosis.
Source: Atherosclerosis - August 4, 2019 Category: Cardiology Authors: L. Charach, G. Charach Tags: Posters 26 - 29 May, 2019 Source Type: research

Perfusion Assessment in Critical Limb Ischemia: Principles for Understanding and the Development of Evidence and Evaluation of Devices: A Scientific Statement From the American Heart Association.
Abstract There are >12 million patients with peripheral artery disease in the United States. The most severe form of peripheral artery disease is critical limb ischemia (CLI). The diagnosis and management of CLI is often challenging. Ethnic differences in comorbidities and presentation of CLI exist. Compared with white patients, black and Hispanic patients have higher prevalence rates of diabetes mellitus and chronic renal disease and are more likely to present with gangrene, whereas white patients are more likely to present with ulcers and rest pain. A thorough evaluation of limb perfusion is important in the ...
Source: Circulation - August 11, 2019 Category: Cardiology Authors: Misra S, Shishehbor MH, Takahashi EA, Aronow HD, Brewster LP, Bunte MC, Kim ESH, Lindner JR, Rich K, American Heart Association Council on Peripheral Vascular Disease; Council on Clinical Cardiology; and Council on Cardiovascular and Stroke Nursing Tags: Circulation Source Type: research

9798 —Hidradenitis suppurativa is associated with increased odds of stroke, coronary artery disease, heart failure, and PAD: A population-based analysis in the United States
Introduction: Hidradenitis suppurativa (HS) and psoriasis has been linked to cardiovascular disease. There is currently a deficiency in the literature regarding the prevalence of clinically important cardiovascular diseases that arise in patients with HS in a United States population. We sought to determine the odds of stroke, coronary artery disease (CAD), heart failure (HF), and peripheral artery disease (PAD) in patients with HS compared with patients with psoriasis and controls.
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Implementation of Supervised Exercise Therapy for Patients With Symptomatic Peripheral Artery Disease: A Science Advisory From the American Heart Association.
sing; Council on Epidemiology and Prevention; and Council on Lifestyle and Cardiometabolic Health Abstract Patients with lower-extremity peripheral artery disease (PAD) have greater functional impairment, faster functional decline, increased rates of mobility loss, and poorer quality of life than people without PAD. Supervised exercise therapy (SET) improves walking ability, overall functional status, and health-related quality of life in patients with symptomatic PAD. In 2017, the Centers for Medicare & Medicaid Services released a National Coverage Determination (CAG-00449N) for SET programs for patients wit...
Source: Circulation - August 25, 2019 Category: Cardiology Authors: Treat-Jacobson D, McDermott MM, Beckman JA, Burt MA, Creager MA, Ehrman JK, Gardner AW, Mays RJ, Regensteiner JG, Salisbury DL, Schorr EN, Walsh ME, American Heart Association Council on Peripheral Vascular Disease; Council on Cardiovascular and Stroke Nu Tags: Circulation Source Type: research

Genetic study ties higher alcohol consumption to increased stroke and PAD risk
(American Heart Association) Using genetic analysis, researchers found higher alcohol consumption increased risks for stroke and peripheral artery disease (PAD).Studies using genetic analysis don't rely on observational data, which often use self-reported data and could be subject to unreported risk factors.
Source: EurekAlert! - Medicine and Health - May 5, 2020 Category: International Medicine & Public Health Source Type: news

Heavy Drinking Tied to Raised Stroke Risk, Study Finds
TUESDAY, May 5, 2020 -- Lots of boozing might increase your risk for a stroke, Swedish researchers report. Heavy alcohol use can triple your risk for peripheral artery disease, a narrowing of arteries that results in reduced blood flow, usually to...
Source: Drugs.com - Daily MedNews - May 5, 2020 Category: General Medicine Source Type: news