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Condition: Staphylococcus Aureus

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Total 124 results found since Jan 2013.

Monoclonal antibodies neutralizing alpha-hemolysin, bicomponent leukocidins, and clumping factor A protected against Staphylococcus aureus-induced acute circulatory failure in a mechanically ventilated rabbit model of hyperdynamic septic shock
ConclusionThese results demonstrate the potential utility of a mechanically ventilated rabbit model that reproduced hallmark clinical features of hyperdynamic septic shock and the translational potential of immunotherapy targeting S. aureus virulence factors for the prevention of staphylococcal septic shock.
Source: Frontiers in Immunology - September 15, 2023 Category: Allergy & Immunology Source Type: research

These ants are ballooning with microbe-killing honey
Buried deep underneath the red, sunbaked soil of Australia’s deserts are hidden treasure troves of honey. It’s not the delicacy produced by bees, but rather the only type of honey made by ants. It’s also, a new study confirms, a potentially powerful medicine with antimicrobial properties. Australia’s Indigenous peoples have long used honey from honeypot ants ( Camponotus inflatus ) to treat a variety of maladies, from sore throats to infected wounds. Now, Western scientists are finally getting up to speed. In a study published today in PeerJ , researchers show that the honeypot ant’s honey has...
Source: Science of Aging Knowledge Environment - July 26, 2023 Category: Geriatrics Source Type: research

Aseptic presentation of interventricular septal abscess with progressive heart block: a case report
ConclusionIntracardiac abscesses should be considered a possible initial differential in patients with progressive heart block despite aseptic presentation and no risk factors.
Source: Journal of Medical Case Reports - April 10, 2023 Category: General Medicine Source Type: research

Unlucky numbers: Fighting murder convictions that rest on shoddy stats
LEIDEN, THE NETHERLANDS— When a Dutch nurse named Lucia de Berk stood trial for serial murder in 2003, statistician Richard Gill was aware of the case. But he saw no reason to stick his nose into it. De Berk was a pediatric nurse at Juliana Children’s Hospital in The Hague. In 2001, after a baby died while she was on duty, a colleague told superiors that De Berk had been present at a suspiciously high number of deaths and resuscitations. Hospital staff immediately informed the police. When investigators reexamined records from De Berk’s shifts, they found 10 suspicious incidents. Three other hospitals where D...
Source: Science of Aging Knowledge Environment - January 19, 2023 Category: Geriatrics Source Type: research

Evaluation of a Novel Synthetic Peptide Derived from Cytolytic Mycotoxin Candidalysin
Toxins (Basel). 2022 Oct 11;14(10):696. doi: 10.3390/toxins14100696.ABSTRACTThe importance of neuroinflammation in neurology is becoming increasingly apparent. In addition to neuroinflammatory diseases such as multiple sclerosis, the role of neuroinflammation has been identified in many non-inflammatory neurological disorders such as stroke, epilepsy, and cancer. The immune response within the brain involves the presence of CNS resident cells; mainly glial cells, such as microglia, the CNS resident macrophages. We evaluated the peptide Ca-MAP1 bioinspired on the C. albicans immature cytolytic toxin candidalysin to develop ...
Source: Cancer Control - October 26, 2022 Category: Cancer & Oncology Authors: Pedro Henrique de Oliveira Cardoso Ana Paula de Ara újo Boleti Patr ícia Souza E Silva Lincoln Takashi Hota Mukoyama Alexya Sandim Guindo Luiz Filipe Ramalho Nunes de Moraes Caio Fernando Ramalho de Oliveira Maria Ligia Rodrigues Macedo Cristiano Marcel Source Type: research

Treatment with IgM-enriched intravenous immunoglobulins (IgM-IVIg) enhances clearance of stroke-associated bacterial lung infection
Immunology. 2022 Jul 26. doi: 10.1111/imm.13553. Online ahead of print.ABSTRACTPost-stroke infection is a common complication of stroke that is associated with poor outcome. We previously reported that stroke induces an ablation of multiple sub-populations of B cells and reduces levels of IgM antibody, which coincides with the development of spontaneous bacterial pneumonia. The loss of IgM after stroke could be an important determinant of infection susceptibility and highlights this pathway as a target for intervention. We treated mice with a replacement dose of IgM-enriched intravenous immunoglobulin (IgM-IVIg) prior to a...
Source: Immunology - July 26, 2022 Category: Allergy & Immunology Authors: Laura McCulloch Alison J Harris Alexandra Malbon Michael J D Daniels Mehwish Younas John R Grainger Stuart M Allan Craig J Smith Barry W McColl Source Type: research

E-136 Morphology of mycotic aneurysms and outcomes
ConclusionPatients with secured mycotic aneurysms are less likely to have in-hospital mortality from postoperative hemorrhage and more likely to have better outcomes upon discharge. This snapshot study warrants further investigation to determine the optimal safe timing between securing IIAs to valvular surgery.Disclosures N. Krothapalli: None. M. Tsikvadze: None. N. Akram: None. A. Elmashad: None. N. Desai: None. A. Tunguturi: None. T. Mehta: None. S. Patel: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Krothapalli, N., Tsikvadze, M., Akram, N., Elmashad, A., Desai, N., Tunguturi, A., Mehta, T., Patel, S. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

Risk Factors for Wound Infections after Vascular Surgery: Kuwait Experience
Conclusion Diabetes, hypertension, ischemic heart disease, hyperlipidemia, and chronic renal failure were all found to have a significant association with post-operative wound infections. An ticipation of wound complications in patients with these risk factors may aid in early diagnosis and treatment.
Source: Medical Principles and Practice - May 19, 2022 Category: Internal Medicine Source Type: research

Etiology, clinical characteristics, and outcome of infective endocarditis: 10-year experience from a tertiary care center in Pakistan
In conclusion, our study provided valuable data on the clinical characteristics and outcomes of patients with IE in a developing country. S. aureus was the most common causative agent. Heart failure and stroke were the most common complications. The presence of prosthetic valves, history of chronic kidney disease, ischemic heart disease and previous stroke were associated with a significantly increased risk of mortality. Surgical management was not associated with improved outcomes.PMID:35347974 | DOI:10.4081/monaldi.2022.2212
Source: Monaldi Archives for Chest Disease - March 29, 2022 Category: Respiratory Medicine Authors: Sara Salim Ali Imran Ahmed Qureshi Ahmed Ayaz Ainan Arshad Awais Farhad Bushra Jamil Muhammad Rizwan Sohail Source Type: research

Very early infective endocarditis after transcatheter aortic valve replacement
ConclusionA significant proportion of IE episodes following TAVR occurs within a few weeks following the procedure and are associated with dismal outcomes. Some baseline and TAVR procedural factors were associated with VE-IE, andStaphylococcus aureus and enterococci were the main causative pathogens. These results may help to select the more appropriate antibiotic prophylaxis in TAVR procedures and guide the initial antibiotic therapy in those cases with a clinical suspicion of IE.Graphical abstractVery early infective endocarditis after trans-catheter aortic valve replacement. VE-IE indicates very early infective endocard...
Source: Clinical Research in Cardiology - March 9, 2022 Category: Cardiology Source Type: research

Fatal Staphylococcus Aureus Endocarditis Misdiagnosed as Multisystem Inflammatory Syndrome in Children
We present a case of a 10-year-old male with Staphylococcus aureus mitral endocarditis who was initially misdiagnosed with multisystem inflammatory syndrome associated with coronavirus disease 2019, with eventual fatal outcome due to brain hemorrhage after cardiac intervention. Our case differs from recent studies, in which microbleeds did not increase the risk of hemorrhagic stroke or global mortality risk.
Source: The Pediatric Infectious Disease Journal - January 19, 2022 Category: Infectious Diseases Tags: Brief Reports Source Type: research