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Phospholipase C-related catalytically inactive protein: A novel signaling molecule for modulating fat metabolism and energy expenditure
ConclusionWe propose PRIP as a new therapeutic target for controlling obesity or developing novel anti-obesity drugs.
Source: Journal of Oral Biosciences - May 16, 2019 Category: Biomedical Science Source Type: research

Association of non-alcoholic fatty liver disease with cardiovascular disease and subclinical atherosclerosis.
Authors: Sao R, Aronow WS Abstract Non-alcoholic fatty liver disease (NAFLD) refers to fatty infiltration of liver in the absence of significant alcohol intake, use of steatogenic medication, or hereditary disorders. It is a common cause of chronic liver disease with a worldwide estimated prevalence ranging from 6.3% to 33%. The NAFLD is considered a hepatic manifestation of the metabolic syndrome. Insulin resistance and increased oxidative stress are central to pathogenesis of NAFLD, and risk factors include metabolic syndrome, diabetes mellitus, obesity, lack of physical activity, smoking, and high fat diet. NAFL...
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Obesity and cardiovascular disease: revisiting an old relationship
A wealth of clinical and epidemiological evidence has linked obesity to a broad spectrum of cardiovascular diseases (CVD) including coronary heart disease, heart failure, hypertension, stroke, atrial fibrillation and sudden cardiac death. Obesity can increase CVD morbidity and mortality directly and indirectly. Direct effects are mediated by obesity-induced structural and functional adaptations of the cardiovascular system to accommodate excess body weight, as well as by adipokine effects on inflammation and vascular homeostasis.
Source: Metabolism - Clinical and Experimental - November 3, 2018 Category: Biomedical Science Authors: Chrysi Koliaki, Stavros Liatis, Alexander Kokkinos Tags: Review Source Type: research

Analysis of genetic and nongenetic factors influencing triglycerides-lowering drug effects based on paired observations
In this study, we assessed both genetic and nongenetic factors that influence drug responses and stratified patients into groups based on differential drug effect and sensitivity. Our methodology of investigating genetic factors and nongenetic factors is applicable to studying differential effects of other drugs, such as statins, and provides an approach to the development of personalized medicine.
Source: BMC Proceedings - September 17, 2018 Category: Biomedical Science Source Type: research

Patients with atrial fibrillation and coronary artery disease – Double trouble
Publication date: March 2018Source: Advances in Medical Sciences, Volume 63, Issue 1Author(s): Ewelina Michniewicz, Elżbieta Mlodawska, Paulina Lopatowska, Anna Tomaszuk-Kazberuk, Jolanta MalyszkoAbstractCoronary artery disease (CAD) is the most common cardiovascular disease while atrial fibrillation (AF) is the most common cardiac arrhythmia. Both diseases share associated risk factors – hypertension, diabetes mellitus, sleep apnea, obesity and smoking. Moreover, inflammation plays a causative role in both diseases. The prevalence of CAD in patients with AF is from 17% to 46.5% while the prevalence of AF among patients...
Source: Advances in Medical Sciences - July 11, 2018 Category: Biomedical Science Source Type: research

Adipose tissue and metabolic and inflammatory responses to stroke are altered in obese mice RESEARCH ARTICLE
ABSTRACT Obesity is an independent risk factor for stroke, although several clinical studies have reported that obesity improves stroke outcome. Obesity is hypothesised to aid recovery by protecting against post-stroke catabolism. We therefore assessed whether obese mice had an altered metabolic and inflammatory response to stroke. Obese ob/ob mice underwent a 20-min middle cerebral artery occlusion and 24-h reperfusion. Lipid metabolism and expression of inflammatory cytokines were assessed in the plasma, liver and adipose tissue. The obese-specific metabolic response to stroke was assessed in plasma using non-targeted ul...
Source: DMM Disease Models and Mechanisms - October 9, 2017 Category: Biomedical Science Authors: Haley, M. J., Mullard, G., Hollywood, K. A., Cooper, G. J., Dunn, W. B., Lawrence, C. B. Tags: RESEARCH ARTICLE Source Type: research

Patients with atrial fibrillation and coronary artery disease – Double trouble
Publication date: March 2018 Source:Advances in Medical Sciences, Volume 63, Issue 1 Author(s): Ewelina Michniewicz, Elżbieta Mlodawska, Paulina Lopatowska, Anna Tomaszuk-Kazberuk, Jolanta Malyszko Coronary artery disease (CAD) is the most common cardiovascular disease while atrial fibrillation (AF) is the most common cardiac arrhythmia. Both diseases share associated risk factors – hypertension, diabetes mellitus, sleep apnea, obesity and smoking. Moreover, inflammation plays a causative role in both diseases. The prevalence of CAD in patients with AF is from 17% to 46.5% while the prevalence of AF among patients with...
Source: Advances in Medical Sciences - August 17, 2017 Category: Biomedical Science Source Type: research

Patients with atrial fibrillation and coronary artery disease - Double trouble.
Abstract Coronary artery disease (CAD) is the most common cardiovascular disease while atrial fibrillation (AF) is the most common cardiac arrhythmia. Both diseases share associated risk factors - hypertension, diabetes mellitus, sleep apnea, obesity and smoking. Moreover, inflammation plays a causative role in both diseases. The prevalence of CAD in patients with AF is from 17% to 46.5% while the prevalence of AF among patients with CAD is low and it is estimated from 0.2% to 5%. AF is a well-established factor of poor short- and long-term prognosis in patients with acute myocardial infarction (AMI) and is associ...
Source: Advances in Medical Sciences - August 14, 2017 Category: Biomedical Science Authors: Michniewicz E, Mlodawska E, Lopatowska P, Tomaszuk-Kazberuk A, Malyszko J Tags: Adv Med Sci Source Type: research

Traumatic Brain Injury, Diabetic Neuropathy and Altered-Psychiatric Health: The Fateful Triangle
Traumatic brain injury is a detrimental medical condition particularly when accompanied by diabetes. There are several comorbidities going along with diabetes including, but not limited to, kidney failure, obesity, coronary artery disease, peripheral vascular disease, hypertension, stroke, neuropathies and amputations. Unlike diabetes type 1, diabetes type 2 is more common in adults who simultaneously suffer from other comorbid conditions making them susceptible to repetitive fall incidents and sustaining head trauma.
Source: Medical Hypotheses - August 7, 2017 Category: Biomedical Science Authors: Hadi Abou-El-Hassan, Batoul Dia, Khalil Choucair, Stephanie A. Eid, Farah Najdi, Lama Baki, Farid Talih, Assaad A. Eid, Firas Kobeissy Source Type: research

Healthy aging of the left ventricle in relationship to cardiovascular risk factors: The Multi-Ethnic Study of Atherosclerosis (MESA)
ConclusionOur results support that LV structure and function are better preserved in senescent hearts in the absence of traditional cardiovascular risk factors, and such protection is more prominent in men than in women.
Source: PLoS One - June 22, 2017 Category: Biomedical Science Authors: Chia-Ying Liu Source Type: research

Vitamin D and Urinary Incontinence among Korean Women: a Propensity Score-matched Analysis from the 2008-2009 Korean National Health and Nutrition Examination Survey.
In conclusion, low serum vitamin D is not significantly and independently related to female UI after propensity score matching in representative Korean data. PMID: 28244294 [PubMed - in process]
Source: Journal of Korean Medical Science - March 2, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Prevalence and Risk Factors of Prehypertension and Hypertension in Southern China
ConclusionsPrehypertension and hypertension are epidemic in southern China. Further studies are needed to explore an indicator that can represent the visceral fat accurately and has a close relationship with cardiovascular disease.
Source: PLoS One - January 16, 2017 Category: Biomedical Science Authors: Lihua Hu Source Type: research

Circulating Adiponectin Levels in Relation to Carotid Atherosclerotic Plaque Presence, Ischemic Stroke Risk, and Mortality: A Systematic Review and Meta-analyses
Low circulating levels of adiponectin, an anti-inflammatory and vasculoprotective adipokine, are associated with obesity, type 2 diabetes, and atherosclerotic disease. Presence of unstable plaques in the carotid artery is a known etiological factor causing ischemic strokes. Herein, we systematically reviewed the association between circulating adiponectin and progression of carotid atherosclerotic disease, particularly evaluating the occurrence of (1) carotid atherosclerotic plaques, (2) ischemic stroke, and (3) mortality in subjects who suffered a previous ischemic stroke.
Source: Metabolism - Clinical and Experimental - January 4, 2017 Category: Biomedical Science Authors: Jessica Gorgui, Karina Gasbarrino, Marios K. Georgakis, Maria A. Karalexi, B énédicte Nauche, Eleni Th. Petridou, Stella S. Daskalopoulou Source Type: research

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