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Specialty: Biomedical Science
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Total 2301 results found since Jan 2013.
Association between electronic nicotine delivery systems use and risk of stroke: a meta-analysis of 1,024,401 participants
CONCLUSIONS: The ENDS usage appears to be associated with a higher risk of stroke compared to non-use, whereas there was no association between former ENDS use and the risk of stroke.PMID:37732043 | PMC:PMC10507757 | DOI:10.5114/aoms/171473
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Kamal Awad Maged Mohammed Seth S Martin Maciej Banach Source Type: research
Analysis of 622 paediatric hospitalisations due to arterial ischaemic stroke in Poland - National Health Fund registry-based study from 2011 to 2020
CONCLUSIONS: Data from the NHF registry proved that AIS occurs more often in boys than in girls and is more common in adolescents (15-18 years) than in younger children.PMID:37732035 | PMC:PMC10507785 | DOI:10.5114/aoms/151684
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Beata Sarecka-Hujar Micha ł Maluchnik Jaros ław Bartosiński Karol Tarkowski Agnieszka Ch łoń-Domińczak Ilona Kopyta Dorota Raczkiewicz Source Type: research
Mouse model hints at pharmacogenomic strategies for stroke treatment in patients possessing a risk variant
Source: Journal of Clinical Investigation - September 15, 2023 Category: Biomedical Science Authors: Douglas E. Vaughan Source Type: research
The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes
Protease-activated receptor 4 (PAR4) (gene F2RL3) harbors a functional dimorphism, rs773902 A/G (encoding Thr120/Ala120, respectively) and is associated with greater platelet aggregation. The A allele frequency is more common in Black individuals, and Black individuals have a higher incidence of ischemic stroke than White individuals. However, it is not known whether the A allele is responsible for worse stroke outcomes. To directly test the in vivo effect of this variant on stroke, we generated mice in which F2rl3 was replaced by F2RL3, thereby expressing human PAR4 (hPAR4) with either Thr120 or Ala120. Compared with hPAR...
Source: Journal of Clinical Investigation - September 15, 2023 Category: Biomedical Science Authors: Frederik Denorme, Nicole D. Armstrong, Michelle L. Stoller, Irina Portier, Emilia A. Tugolukova, Rikki M. Tanner, Emilie Montenont, Seema Bhatlekar, Mark Cody, John L. Rustad, Abigail Ajanel, Neal D. Tolley, Darian C. Murray, Julie L. Boyle, Marvin T. Nie Source Type: research
Report on Cardiovascular Health and Diseases in China 2022: an Updated Summary
Biomed Environ Sci. 2023 Aug 20;36(8):669-701. doi: 10.3967/bes2023.106.ABSTRACTIn the past 30 years, the accessibility and quality index of medical care have made remarkable progress in China, ranking the first among middle-income countries. Many cardiovascular technologies are at or near the world's leading level, and significant progress has been achieved in China solving the problem of "treatment difficulty" of cardiovascular diseases (CVD). However, due to the prevalence of unhealthy lifestyles among Chinese residents, a huge population with CVD risk factors, accelerated population aging, and other reasons, the incide...
Source: Biomedical and Environmental Sciences : BES - September 15, 2023 Category: Biomedical Science Authors: Writing Committee Of The Report On Cardiovascular Health And Diseases In China The Source Type: research
Mortality risk after the first occurrence of osteoporotic vertebral compression fractures in the general population: A nationwide cohort study
This study aimed to evaluate mortality risk after the first occurrence of OVCF in the general population using a nationwide dataset from the Korean National Health Insurance System. We identified 291,203 newly diagnosed patients with OVCF and 873,609 patients without OVCF at a ratio of 1:3 matched by sex and age between 2010 and 2012. We investigated the latent characteristics of patients’ demographic information and chronic comorbidities that could affect mortality when diagnosed with OVCF. By comparing the cohort data, the hazar d ratio for subsequent mortality in patients with OVCF was calculated and adjusted based on...
Source: PLoS One - September 14, 2023 Category: Biomedical Science Authors: Hee Jung Son Source Type: research
Modeling the public health impact of voxelotor in the management of sickle cell disease in France
The objective of this study was to estimate the impact of voxelotor on the burden of SCD in France using a modeling approach, accounting for its anticipated adoption and diffusion over the next 5 years. We designed a sequential multi-cohort model to project and compare the cumulative incidence of SCD complications over a 20-year time horizon in a world with and without voxelotor. A distribution of patients was simulated across various levels of Hb response based on the phase 3 HO PE trial results, and relative risk reduction was adjusted using published meta-analysis results that projected risk reduction due to a 1 g/dL in...
Source: PLoS One - September 13, 2023 Category: Biomedical Science Authors: Fr édéric Galacteros Source Type: research
Galectin-3 promotes brain injury by modulating the phenotype of microglia via binding TLR-4 after intracerebral hemorrhage
CONCLUSIONS: This study proves that Gal-3 is involved in neuroinflammation and nerve damage after ICH. Gal-3 expression should not be encouraged early on to prevent neuroinflammation. which provides a new possibility for clinical treatment for ICH patients.PMID:37698533 | DOI:10.18632/aging.205014
Source: Aging - September 12, 2023 Category: Biomedical Science Authors: Tianyu Liang Zheng Zhu Fangxiao Gong Xiaobo Yang Xiaoju Lei Ling Lu Source Type: research
Herpesvirus latent infection promotes stroke via activating the OTUD1/NF- κB signaling pathway
CONCLUSION: Herpes virus latent infection promotes cerebral infarction by activating the OTUD1/NF-κB signaling pathway.PMID:37695739 | DOI:10.18632/aging.205011
Source: Aging - September 11, 2023 Category: Biomedical Science Authors: Jiacai Lin Yangrui Zheng Ning Zhao Fang Cui Siting Wu Source Type: research
