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Insulin Regulation of Hepatic Lipid Homeostasis
Compr Physiol. 2023 Jun 26;13(3):4785-4809. doi: 10.1002/cphy.c220015.ABSTRACTThe incidence of obesity, insulin resistance, and type II diabetes (T2DM) continues to rise worldwide. The liver is a central insulin-responsive metabolic organ that governs whole-body metabolic homeostasis. Therefore, defining the mechanisms underlying insulin action in the liver is essential to our understanding of the pathogenesis of insulin resistance. During periods of fasting, the liver catabolizes fatty acids and stored glycogen to meet the metabolic demands of the body. In postprandial conditions, insulin signals to the liver to store exc...
Source: Comprehensive Physiology - June 26, 2023 Category: Physiology Authors: Kahealani Uehara Dominic Santoleri Anna E Garcia Whitlock Paul M Titchenell Source Type: research

16.5MILLION Americans at risk of stroke from EXERCISING too hard, study suggests
Overweight and obese people may have a partial blockage in their carotid arteries - running to the brain via the neck - due to a build-up of plaque, scientists in India warned.
Source: the Mail online | Health - June 24, 2023 Category: Consumer Health News Source Type: news

PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis
Hum Reprod Update. 2023 Jun 23:dmad015. doi: 10.1093/humupd/dmad015. Online ahead of print.ABSTRACTBACKGROUND: Current knowledge about the consequences of PCOS during the late reproductive years and after menopause is limited.OBJECTIVE AND RATIONALE: We performed a systematic review and meta-analysis of data on the pathophysiology, clinical manifestations, diagnosis, prognosis, and treatment of women ≥45 years of age-peri- or postmenopausal-with PCOS.SEARCH METHODS: Studies published up to 15 April 2023, identified by Entrez-PubMed, EMBASE, and Scopus online facilities, were considered. We included cross-sectional or pro...
Source: Cancer Control - June 24, 2023 Category: Cancer & Oncology Authors: Mercedes Mill án-de-Meer Manuel Luque-Ram írez L ía Nattero-Chávez H éctor F Escobar-Morreale Source Type: research

Is increased myocardial triglyceride content associated with early changes in left ventricular function? A 1H-MRS and MRI strain study
ConclusionsPredicting MTGC remains a challenge in routine clinical practice, as only BMI independently correlates with increased MTGC. MTGC may play a role in LV dysfunction but does not appear to be involved in the development of subclinical strain abnormalities.
Source: Frontiers in Endocrinology - June 22, 2023 Category: Endocrinology Source Type: research

Metabolic syndrome and osteoarthritis: implications for the management of an increasingly common phenotype
Metabolic syndrome is an accumulation of three or more seemingly benign and relatively common conditions (central obesity, hypertension, raised triglycerides, low HDL-cholesterol, glucose intolerance) that, together, increase the risk of developing serious chronic disease.1 It is estimated that one-quarter of adults worldwide have metabolic syndrome2 — a concerning statistic considering that this population is five times more likely to develop diabetes, and two-to-three times more likely to develop heart disease, stroke, and certain cancers.
Source: Osteoarthritis and Cartilage - June 20, 2023 Category: Rheumatology Authors: Casey L Peiris, Adam G Culvenor Tags: Editorial Source Type: research

7 Myths About Cholesterol, Debunked
You may not recall every lab value from your last physical, but you probably remember one: Your cholesterol level. If it’s higher than ideal, you’re not alone. According to the U.S. Centers for Disease Control and Prevention, between 2015 and 2018, almost 12% of U.S. adults ages 20 and up had high total cholesterol, defined as above 240 mg/dL. The type that physicians mostly worry about is LDL (or “bad”) cholesterol, which is one component of that total. Why do doctors care so much about cholesterol? First, “it predicts risk,” says Dr. Jeffrey Berger, a cardiologist and director of the C...
Source: TIME: Health - June 19, 2023 Category: Consumer Health News Authors: Katherine Hobson Tags: Uncategorized freelance healthscienceclimate heart health Source Type: news

ApoC-III Proteoforms, Plasma Lipids, and Cardiovascular Risk in MESA
CONCLUSIONS: Our data indicate differences in clinical and demographic relationships of apoC-III proteoforms, and highlight the importance of apoC-III proteoform composition in predicting future lipid patterns and cardiovascular disease risk.PMID:37317850 | DOI:10.1161/ATVBAHA.123.319035
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 15, 2023 Category: Cardiology Authors: Shripad Sinari Juraj Koska Yueming Hu Jeremy Furtado Majken K Jensen Matthew J Budoff Dobrin Nedelkov Robyn L McClelland Dean Billheimer Peter Reaven Source Type: research

FTO alleviates cerebral ischemia/reperfusion-induced neuroinflammation by decreasing cGAS mRNA stability in an m6A-dependent manner
In conclusion, this study deepens our understanding on the relationship of m6A modification and microglia-mediated inflammation in cerebral I/R injury, and insights a novel m6A-based therapeutic for inhibiting inflammatory response against ischemic stroke.PMID:37321527 | DOI:10.1016/j.cellsig.2023.110751
Source: Cellular Signalling - June 15, 2023 Category: Cytology Authors: Zhiyong Yu Linbo Zheng Yan Geng Yuting Zhang Yupeng Wang Guoxing You Mingsheng Cai Meili Li Xiao Cheng Jie Zan Source Type: research

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