FTO alleviates cerebral ischemia/reperfusion-induced neuroinflammation by decreasing cGAS mRNA stability in an m6A-dependent manner

In conclusion, this study deepens our understanding on the relationship of m6A modification and microglia-mediated inflammation in cerebral I/R injury, and insights a novel m6A-based therapeutic for inhibiting inflammatory response against ischemic stroke.PMID:37321527 | DOI:10.1016/j.cellsig.2023.110751

Source: Cellular Signalling - June 15, 2023 Category: Cytology Authors: Zhiyong Yu Linbo Zheng Yan Geng Yuting Zhang Yupeng Wang Guoxing You Mingsheng Cai Meili Li Xiao Cheng Jie Zan Source Type: research