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Condition: Obesity
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Total 4516 results found since Jan 2013.
Risk and population attributable fraction of stroke subtypes in Japan
CONCLUSION: Although there are differences according to the subtypes, hypertension could be regarded as the most crucial target for preventing strokes in Japan.PMID:37460296 | DOI:10.2188/jea.JE20220364
Source: Journal of Epidemiology - July 17, 2023 Category: Epidemiology Authors: Hiroshi Yatsuya Kazumasa Yamagishi Yuanying Li Isao Saito Yoshihiro Kokubo Isao Muraki Manami Inoue Shoichiro Tsugane Hiroyasu Iso Norie Sawada Source Type: research
ICAM-1 and VCAM-1: gatekeepers in various inflammatory and cardiovascular disorders
Clin Chim Acta. 2023 Jul 11:117487. doi: 10.1016/j.cca.2023.117487. Online ahead of print.ABSTRACTLeukocyte migration from the vascular compartment is critical fornormal lymphocyte recirculation in specific tissues and immune response in inflammatory locations. Leukocyte recruitment, migration to inflammatory areas, and targeting in the extravascular space are caused by cellular stimulation and local expression of adhesion molecules. Intercellular adhesion molecule 1 (ICAM-1) and Vascular cell adhesion molecule 1 (VCAM-1) belong to the immunoglobulin superfamily of cell adhesion molecules with a crucial role in mediating t...
Source: International Journal of Clinical Chemistry - July 13, 2023 Category: Chemistry Authors: Varinder Singh Rupinder Kaur Pratima Kumari Chirag Pasricha Ravinder Singh Source Type: research
GSE225671 The role of stromal and immune cells in atrial disease III
Contributors : Maarten Hulsmans ; Maximilian J Schloss ; I-Hsiu Lee ; Kamila Naxerova ; Matthias NahrendorfSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn atrial fibrillation, disturbed electrical conduction disrupts the coordinated contraction of the heart ’s antechambers, increasing the risk of stroke and heart failure. The rising prevalence of this disease approaches 9% in patients>65 years. Studying freshly isolated human atrial tissue and a new mouse model, we here decipher how immune and stromal cells contribute to the structural tissue remodeling that underlies atrial fibr...
Source: GEO: Gene Expression Omnibus - July 13, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE224947 The role of stromal and immune cells in atrial disease II
Contributors : Maarten Hulsmans ; Maximilian J Schloss ; I-Hsiu Lee ; Kamila Naxerova ; Matthias NahrendorfSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn atrial fibrillation, disturbed electrical conduction disrupts the coordinated contraction of the heart ’s antechambers, increasing the risk of stroke and heart failure. The rising prevalence of this disease approaches 9% in patients>65 years. Studying freshly isolated human atrial tissue and a new mouse model, we here decipher how immune and stromal cells contribute to the structural tissue remodeling that underlies atrial fibr...
Source: GEO: Gene Expression Omnibus - July 13, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE197518 The role of stromal and immune cells in atrial disease I
Contributors : Maarten Hulsmans ; Maximilian J Schloss ; I H Lee ; George Tolis ; Serguei Melnitchouk ; Kamila Naxerova ; Matthias NahrendorfSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusIn atrial fibrillation, disturbed electrical conduction disrupts the coordinated contraction of the heart ’s antechambers, increasing the risk of stroke and heart failure. The rising prevalence of this disease approaches 9% in patients>65 years. Studying freshly isolated human atrial tissue and a new mouse model, we here decipher how immune and stromal cells contribute to the struct...
Source: GEO: Gene Expression Omnibus - July 13, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Mus musculus Source Type: research
Which Antiplatelet Agent for Patients With TIA and Obesity? Which Antiplatelet Agent for Patients With TIA and Obesity?
Ticagrelor plus aspirin was associated with a lower risk for recurrent stroke than clopidogrel plus aspirin in patients with obesity who carry the CYP2C19 loss-of-function allele.Medscape Medical News
Source: Medscape FamilyMedicine Headlines - July 12, 2023 Category: Primary Care Tags: Cardiology News Source Type: news
Women with PCOS have an increased risk for cardiovascular disease regardless of diagnostic criteria - a prospective population-based cohort study
CONCLUSIONS: PCOS should be considered a significant risk factor for CVD. Future follow-up will show how the risk of CVD events develops after menopausal age.PMID:37436934 | DOI:10.1093/ejendo/lvad077
Source: European Journal of Endocrinology - July 12, 2023 Category: Endocrinology Authors: M M Ollila R K Arffman E Korhonen L Morin-Papunen S Franks J Junttila T T Piltonen Source Type: research
Body mass index and waist circumference as predictors of recurrent vascular events after a recent ischemic stroke
Obesity is an independent contributor to ischemic stroke incidence. A meta-analysis of 13 studies revealed that a 5 kg/m2 increase in body mass index (BMI) was associated with a 22% increased risk of ischemic stroke in European/North American/Australian cohorts and a 35% increased risk of ischemic stroke among the Asian populations.1 In a meta-analysis of 7 prospective studies, persons in the highest waist circumference (WC) category had a relative risk of 1.41 (95% CI, 1.21 –1.56) for ischemic stroke compared with persons in the lowest category.
Source: Journal of Stroke and Cerebrovascular Diseases - July 11, 2023 Category: Neurology Authors: Kyusik Kang, Jong-Moo Park, Wi-Sun Ryu, Sang-Wuk Jeong, Dong-Eog Kim, Hong-Kyun Park, Yong-Jin Cho, Keun-Sik Hong, Kyung Bok Lee, Tai Hwan Park, Sang-Soon Park, Juneyoung Lee, Beom Joon Kim, Moon-Ku Han, Hee-Joon Bae Source Type: research
Ticagrelor-Acetylsalicylic Acid More Beneficial for Obese With Minor Stroke, TIA
MONDAY, July 10, 2023 -- For patients with minor stroke or transient ischemic attack (TIA) who carry the CYP2C19 loss-of-function allele, those with obesity receive more clinical benefit from ticagrelor-acetylsalicylic acid (ASA) than...
Source: Drugs.com - Pharma News - July 10, 2023 Category: Pharmaceuticals Source Type: news
Impact of body mass index on efficacy and safety of ticagrelor versus clopidogrel in patients with minor stroke or transient ischemic attack
CMAJ. 2023 Jul 10;195(26):E897-E904. doi: 10.1503/cmaj.230262.ABSTRACTBACKGROUND: Body mass index (BMI) may affect the response to platelet P2Y12 receptor inhibitors. We aimed to explore whether BMI influenced the efficacy and safety of ticagrelor and clopidogrel for secondary prevention of minor ischemic stroke or transient ischemic attack (TIA) among patients enrolled in the CHANCE-2 (Ticagrelor or Clopidogrel with Aspirin in High-Risk Patients with Acute Nondisabling Cerebrovascular Events II) trial.METHODS: In a multicentre, randomized, double-blind, placebo-controlled trial, conducted in China, we randomized patients ...
Source: cmaj - July 10, 2023 Category: General Medicine Authors: Jia Zhang Anxin Wang Xue Tian Xia Meng Xuewei Xie Jing Jing Jinxi Lin Yilong Wang Zixiao Li Liping Liu Hao Li Yong Jiang Xingquan Zhao Yongjun Wang Source Type: research
