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Condition: Motor Neurone Disease

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Total 256 results found since Jan 2013.

Pseudo spastic gait can reveal a Stiff Leg Syndrome (SLS)
Spastic gait is classically link to a corticospinal syndrome related to upper motor neuron involvement from various causes (stroke, multiple sclerosis, cerebral tumor, motor neuron disorders…). Focal dystonia is another cause of limb stiffness. Several conditions resulting in abnormal movements, postures, or spasm that may resemble spastic gait or focal dystonia have been recognized (including disorders of the central and peripheral nervous systems as well as non-neurological conditions).
Source: Clinical Neurology and Neurosurgery - June 11, 2016 Category: Neurosurgery Authors: Coline Duwicquet, Julien Biberon, Bertrand de Toffol, Philippe Corcia Tags: Case Report Source Type: research

Increased functional connectivity common to symptomatic amyotrophic lateral sclerosis and those at genetic risk
Conclusions Rather than structural brain changes, increased FC may be among the earliest detectable brain abnormalities in asymptomatic carriers of ALS-causing gene mutations. With replication and significant refinement, this technique has potential in the future assessment of neuroprotective strategies.
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 12, 2016 Category: Neurosurgery Authors: Menke, R. A. L., Proudfoot, M., Wuu, J., Andersen, P. M., Talbot, K., Benatar, M., Turner, M. R. Tags: Open access, Genetics, Brain stem / cerebellum, Motor neurone disease, Neuromuscular disease, Spinal cord, Stroke, Radiology, Radiology (diagnostics) Neurodegeneration Source Type: research

Enteral feeding in neurological disorders.
Abstract Malnutrition and weight loss, due to suboptimal oral intake, are common in patients with neurological disorders and are associated with increased morbidity, disability and mortality. The nutritional management of neurological patients is crucial, and enteral feeding is commonly used to provide nutritional support. This review presents the different methods of enteral tube feeding and discusses its practice and efficacy in terms of clinical outcomes in the context of motor neurone disease, Parkinson's disease, Alzheimer's disease and other dementias, and stroke. PMID: 27152026 [PubMed - as supplied by publisher]
Source: Practical Neurology - May 4, 2016 Category: Neurology Authors: Stavroulakis T, McDermott CJ Tags: Pract Neurol Source Type: research

Response to “Comment on ‘Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research’”
Research and Toxicology Department, Humane Society International, London, United Kingdom About This Article open Citation: Langley G. 2016. Response to “Comment on ‘Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research.’” Environ Health Perspect 124:A85; http://dx.doi.org/10.1289/ehp.1611305 Address correspondence to G. Langley, 8 Crow Furlong, Hitchin, Hertfordshire, SG5 2HW, United Kingdom. E-mail: sciencesources@btinternet.com The author works for Humane Society International, one of whose goals is the phasing out of animal use in testing and research. Final Publication: 1...
Source: EHP Research - May 2, 2016 Category: Environmental Health Authors: Web Admin Tags: Correspondence May 2016 Source Type: research

Prevalence of people who could benefit from augmentative and alternative communication (AAC) in the UK: determining the need.
CONCLUSIONS & IMPLICATIONS: To provide accurate figures on the potential need for and use of AAC, data need to be consistently and accurately recorded and regularly reviewed at a community level. The existing data suggest an urgent need for more accurate and up to date information to be captured about the need for AAC in the UK to provide better services and ensure access to AAC strategies, equipment and support. PMID: 27113569 [PubMed - as supplied by publisher]
Source: International Journal of Language and Communication Disorders - April 25, 2016 Category: Speech Therapy Authors: Creer S, Enderby P, Judge S, John A Tags: Int J Lang Commun Disord Source Type: research

Neurological Features of Bechet Syndrome: A Case Series (P3.379)
CONCLUSIONS: This case series study helps to understand better the variant neurological features of Behcet’s disease, which will facilitate the diagnosis and appropriate treatment.Disclosure: Dr. Yu has nothing to disclose. Dr. Jiang has nothing to disclose. Dr. Xia has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Yu, K., Jiang, N., Xia, G. Tags: General Neurology Source Type: research

The Evaluation and Management of Alternative Diagnoses in Amyotrophic Lateral Sclerosis (P5.091)
Conclusions: Treatment with intravenous steroids, immunoglobulin and surgical interventions prior to diagnosis of ALS is associated with a significantly prolonged mean ODI.Disclosure: Dr. Kannan has nothing to disclose. Dr. Glass has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Kannan, M., Glass, J. Tags: Neuroepidemiology: Neuro-oncology and ALS Source Type: research

Unusual Intersection: Elucidating the Role of Erdheim Chester Disease in Stroke (P4.366)
Conclusion:A unifying diagnosis of ECD was identified for this gentleman presenting with a stroke in the setting of critical ICA stenosis. Pathology from his CEA suggests that while ECD involves multisystem inflammation, it did not appear to play a direct role in his stroke.Disclosure: Dr. Sheikhi has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Sheikhi, L. Tags: Cerebrovascular Case Reports Source Type: research

Erectile Dysfunction in Individuals with Neurologic Disability: A Hospital-based Cross-sectional Study
Conclusion: The occurence of erectile dysfunction is significantly more prevalent among neurologically disabled men, particularly those with lesions below S2–S4, than among men without neurologic disability. Considering the prevalence of erectile dysfunction among neurologically disabled men, sexual functioning should be regularly evaluated during acute and long-term rehabilitation, and any existing sexual dysfunction should be addressed in the treatment plan. Introduction Penile erection is a neurovascular event characterized by the dilation of arteries that cause the corpora cavernosa and corpora spongiosum of the peni...
Source: Innovations in Clinical Neuroscience - February 22, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Medical Issues Neurologic Systems and Symptoms Neurology Neuromuscular Disease Original Research Neurogenic SD; Erectile Dysfunction; sexual health; Quality of life Source Type: research

Effects of repetitive transcranial magnetic stimulation on lower extremity spasticity and motor function in stroke patients.
CONCLUSION: Low-frequency rTMS over the LE motor area can improve clinical measures of muscle spasticity and motor function. More studies are needed to clarify the changes underlying this improvement in spasticity. Implications for Rehabilitation Spasticity is a common disorder and one of the causes of long-term disability after stroke. Physical therapy modalities, oral medications, focal intervention and surgical procedures have been used for spasticity reduction. Beneficial effect of the repetitive transcranial magnetic stimulation (rTMS) for post-stroke upper extremity spasticity reduction and motor function improvement...
Source: Disability and Rehabilitation - February 15, 2016 Category: Rehabilitation Authors: Rastgoo M, Naghdi S, Nakhostin Ansari N, Olyaei G, Jalaei S, Forogh B, Najari H Tags: Disabil Rehabil Source Type: research

Cerebrovascular injury as a risk factor for amyotrophic lateral sclerosis
Conclusions Cerebrovascular injury from a variety of causes, rather than the presence of AVM or the associated embolisation procedure per se, may be a risk factor for ALS within the context of a more complex multiple-hit model of pathogenesis.
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 14, 2016 Category: Neurosurgery Authors: Turner, M. R., Goldacre, R., Talbot, K., Goldacre, M. J. Tags: Open access, Genetics, Drugs: CNS (not psychiatric), Motor neurone disease, Neuromuscular disease, Spinal cord, Stroke Neurodegeneration Source Type: research

Erectile Dysfunction in Individuals with Neurologic Disability: A Hospital-based, Cross-sectional Study
Conclusion: The occurence of erectile dysfunction is significantly more prevalent among neurologically disabled men, particularly those with lesions below S2–S4, than among men without neurologic disability. Considering the prevalence of erectile dysfunction among neurologically disabled men, sexual functioning should be regularly evaluated during acute and long-term rehabilitation, and any existing sexual dysfunction should be addressed in the treatment plan. Introduction Penile erection is a neurovascular event characterized by the dilation of arteries that cause the corpora cavernosa and corpora spongiosum of the peni...
Source: Innovations in Clinical Neuroscience - February 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Medical Issues Neurologic Systems and Symptoms Neurology Neuromuscular Disease Original Research Neurogenic SD; Erectile Dysfunction; sexual health; Quality of life Source Type: research

A single blind, clinical trial to investigate the effects of a single session extracorporeal shock wave therapy on wrist flexor spasticity after stroke.
CONCLUSIONS: In adult patients after stroke, a single session of active ESWT resulted in significant improvement in the wrist flexor spasticity and alpha motor neuron excitability. PMID: 25547767 [PubMed - indexed for MEDLINE]
Source: NeuroRehabilitation - January 25, 2016 Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research

Ischemic Cervical Myelopathy Caused by Vertebral Artery Dissection: The Clinical Utility of a Motor-evoked Potential Study
Conclusions: When there is diagnostic ambiguity between the upper and lower motor neuron lesions in VAD, motor-evoked potential study can be helpful to diagnose peripheral neurological complication of VAD.
Source: The Neurologist - December 28, 2015 Category: Neurology Tags: Case Report/Case Series Source Type: research

In Vivo Imaging of Human Sarcomere Twitch Dynamics in Individual Motor Units
Publication date: 16 December 2015 Source:Neuron, Volume 88, Issue 6 Author(s): Gabriel N. Sanchez, Supriyo Sinha, Holly Liske, Xuefeng Chen, Viet Nguyen, Scott L. Delp, Mark J. Schnitzer Motor units comprise a pre-synaptic motor neuron and multiple post-synaptic muscle fibers. Many movement disorders disrupt motor unit contractile dynamics and the structure of sarcomeres, skeletal muscle’s contractile units. Despite the motor unit’s centrality to neuromuscular physiology, no extant technology can image sarcomere twitch dynamics in live humans. We created a wearable microscope equipped with a microendoscope...
Source: Neuron - December 18, 2015 Category: Neuroscience Source Type: research