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Condition: Motor Neurone Disease

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Total 256 results found since Jan 2013.

Manifestations of an Uncommon Pontine Insult, Eight-and-a-Half Syndrome (P1.029)
CONCLUSIONS: EHS involves a specific constellation of clinical findings which include OHS and LMN facial palsy, all ipsilateral to the side of the lesion at the level of the pons. On the basis of our review, true EHS is a very rare manifestation. EHS variants, while still unique, are more common.Disclosure: Dr. mannel has nothing to disclose. Dr. Saada has nothing to disclose. Dr. Antonios has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Mannel, R., Saada, F., Antonios, N. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

Symptomatic Cerebral Air Embolism after Central Venous Catheter Removal. (P1.034)
CONCLUSIONS: Central air embolism is a rare complication of central venous catheter removal or insertion. GRE or DWI is useful for diagnosis of cerebral air embolism. Clinician should be aware of this uncommon complication and take the necessary precaution to prevent it.Disclosure: Dr. Ferdous has nothing to disclose. Dr. Tantikittichaikul has nothing to disclose. Dr. Hasan has nothing to disclose. Dr. Eldokla has nothing to disclose. Dr. Kim has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Ferdous, J., Tantikittichaikul, S., Hasan, R., Eldokla, A., Kim, J. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

Amyotrophic Lateral Sclerosis (ALS) with Laboratory Abnormalities of Unknown Significance (LAUS) --Where Does It Begin and Where Does It End? (P4.144)
CONCLUSIONS: Further detailed analysis of progression rate by site of onset, sex, age, treatment will require assimilation of clinic-based datasets of properly analyzed ALS-LAUS patients from multiple clinic sites. The appropriate role of IVIg in ALS-LAUS patients requires further study following explication of the natural history of these patients compared with non-ALS-LAUS patients. The determination as to whether auto-antibodies to additional antigens may play a role in the progression rate of ALS-LAUS compared with sporadic ALS needs to be systematically studied. Study Supported by: Carolinas ALS Research FundDisclosur...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Brooks, B., Bravver, E., Langford, V., Alwan, M., Smith, N., Lucas, N., Nichols, M., Belcher, S., Lary, C., Nemeth, J., Russo, P., Wright, K., Ward, A., Holsten, S., Fischer, M., Bockenek, W., Desai, U., Lindblom, S. C., Pacicco, T., Sanjak, M. Tags: Neuroepidemiology: ALS Source Type: research

Phenotypes and Genotypes of Mitochondrial Disease- Findings from A National Mitochondrial Disease Cohort (P2.061)
Conclusion: This national cohort offers a unique opportunity to deep phenotype a large group of mitochondrial disease patients, bridge the gap in our understanding of disease progression, develop clinical guideline on patient care and facilitate patient recruitment for any future trials.Disclosure: Dr. Ng has nothing to disclose. Dr. Gorman has nothing to disclose. Dr. Nesbitt has nothing to disclose. Dr. Pitceathly has nothing to disclose. Dr. Grady has nothing to disclose. Dr. Schaefer has nothing to disclose. Dr. Bright has nothing to disclose. Dr. Feeney has nothing to disclose. Dr. Rahman has nothing to disclose. Dr. ...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Ng, Y. S., Gorman, G., Nesbitt, V., Pitceathly, R., Grady, J., Schaefer, A., Bright, A., Feeney, C., Rahman, S., Poulton, J., Taylor, R., Hanna, M., Turnbull, D., McFarland, R. Tags: ALS and Motor Neuron Disease Source Type: research

When is feeding via a percutaneous endoscopic gastrostomy indicated?
Purpose of review: This review addresses current controversies regarding appropriate indications for percutaneous endoscopic gastrostomy (PEG) insertion. We address specific indications, namely, dementia, stroke, aspiration, motor neurone disease/amyotrophic lateral sclerosis, and head and neck cancer. We recommend practical strategies for improving patient selection. Recent findings: There is now a general consensus in the United States that PEG feeding does not benefit patients with advanced dementia. ‘Early’ PEG insertion following stroke is similarly of no benefit. It is currently unclear whether patients with amyo...
Source: Current Opinion in Gastroenterology - February 6, 2015 Category: Gastroenterology Tags: NUTRITION: Edited by Eamonn M.M. Quigley Source Type: research

Constraint-Induced Movement Therapy After Injection of Botulinum Toxin Type A for a Patient With Chronic Stroke: One-Year Follow-up Case Report.
DISCUSSION: The improved arm function could reflect improvements in volitional movements and coordination or speed of movements in the paretic arm that resulted from a reduction in spasticity, a reduction of learned nonuse behaviors, or use-dependent plasticity after the combination of BTX type A and constraint-induced movement therapy. If this approach proves useful in future controlled studies, this may halt the rising medical costs of the treatment of stroke. PMID: 25592185 [PubMed - as supplied by publisher]
Source: Physical Therapy - January 15, 2015 Category: Physiotherapy Authors: Amano S, Takebayashi T, Hanada K, Umeji A, Marumoto K, Furukawa K, Domen K Tags: Phys Ther Source Type: research

A single blind, clinical trial to investigate the effects of a single session extracorporeal shock wave therapy on wrist flexor spasticity after stroke
CONCLUSIONS: In adult patients after stroke, a single session of active ESWT resulted in significant improvement in the wrist flexor spasticity and alpha motor neuron excitability. Content Type Journal ArticlePages -DOI 10.3233/NRE-141193Authors Seyedeh Somayeh Daliri, Department of Physical Medicine and Rehabilitation, School of Medicine, Iran University of Medical Sciences, Tehran, IranBijan Forogh, Department of Physical Medicine and Rehabilitation, School of Medicine, Iran University of Medical Sciences, Tehran, IranSeyedeh Zahra, Department of Physical Medicine and Rehabilitation, School of Medicine, Iran Universit...
Source: NeuroRehabilitation - December 29, 2014 Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research

Pathophysiology of Spasticity: Implications for Neurorehabilitation.
Abstract Spasticity is the velocity-dependent increase in muscle tone due to the exaggeration of stretch reflex. It is only one of the several components of the upper motor neuron syndrome (UMNS). The central lesion causing the UMNS disrupts the balance of supraspinal inhibitory and excitatory inputs directed to the spinal cord, leading to a state of disinhibition of the stretch reflex. However, the delay between the acute neurological insult (trauma or stroke) and the appearance of spasticity argues against it simply being a release phenomenon and suggests some sort of plastic changes, occurring in the spinal cor...
Source: Biomed Res - December 26, 2014 Category: Research Authors: Trompetto C, Marinelli L, Mori L, Pelosin E, Currà A, Molfetta L, Abbruzzese G Tags: Biomed Res Int Source Type: research

Lost memories might be able to be restored, new UCLA study indicates
New UCLA research indicates that lost memories can be restored. The findings offer some hope for patients in the early stages of Alzheimer’s disease. For decades, most neuroscientists have believed that memories are stored at the synapses — the connections between brain cells, or neurons — which are destroyed by Alzheimer’s disease. The new study provides evidence contradicting the idea that long-term memory is stored at synapses. “Long-term memory is not stored at the synapse,” said David Glanzman, a senior author of the study, and a UCLA professor of integrative biology and physiology and of neurobiology. “...
Source: UCLA Newsroom: Health Sciences - December 19, 2014 Category: Universities & Medical Training Source Type: news

A fine neuroscience vintage
I recently bumped into a cardiologist mate who had just won a silver medal for his first wild barrel ferment Chardonnay from the vineyard he started with a haematologist, their wine label aptly named Blood Brothers. He told me his approach to cultivating a fine harvest. While many factors play a role he said, the raw product and how it is nurtured, remains the key. The grape variety and how it responds to the prevailing climate at the time of harvest are the critical factors in producing a fine wine vintage. After our conversation, I was impelled to draw a parallel between his wine making and the process of extracting prac...
Source: Journal of Neurology, Neurosurgery and Psychiatry - December 17, 2014 Category: Neurosurgery Authors: Kiernan, M. C. Tags: Genetics, Long term care, Immunology (including allergy), Dementia, Epilepsy and seizures, Motor neurone disease, Movement disorders (other than Parkinsons), Multiple sclerosis, Neuromuscular disease, Peripheral nerve disease, Spinal cord, Stroke, Memory Source Type: research

Alternative functions of the brain transsulfuration pathway represent an underappreciated aspect of brain redox biochemistry with significant potential for therapeutic engagement.
Abstract Scientific appreciation for the subtlety of brain sulfur chemistry has lagged, despite understanding that the brain must maintain high glutathione (GSH) to protect against oxidative stress in tissue that has both a high rate of oxidative respiration and a high content of oxidation-prone polyunsaturated fatty acids. In fact, the brain was long thought to lack a complete transsulfuration pathway (TSP) for cysteine synthesis. It is now clear that not only does the brain possess a functional TSP, but brain TSP enzymes catalyze a rich array of alternative reactions that generate novel species including the gas...
Source: Free Radical Biology and Medicine - November 6, 2014 Category: Biology Authors: Hensley K, Denton TT Tags: Free Radic Biol Med Source Type: research

Managing upper extremity clonus with intramuscular botulinum toxin-A injections in a patient post-stroke
Spasticity and clonus are common clinical signs of upper motor neuron lesions post-stroke. Intramuscular botulinum toxin-A injections have been shown to reduce spasticity and improve quality of life. Upper extremity clonus can have a significant impact upon activities of daily living and can pose challenges to comfort, self-care, hygiene, and appearance. Although less common than in ankle, it is important to understand how upper extremity clonus management may be beneficial to patients presenting with this finding.
Source: PM and R - October 31, 2014 Category: Rehabilitation Authors: Adam Kassam, Chetan P. Phadke, Farooq Ismail, Chris Boulias Source Type: research

Motor Neuron Diseases
Motor neuron diseases information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS).
Source: NINDS Disorders: National Institute of Neurological Disorders and Stroke - October 26, 2014 Category: Neurology Source Type: research

A pilot study on the effects of low frequency repetitive transcranial magnetic stimulation on lower extremity spasticity and motor neuron excitability in patients after stroke
To evaluate the effect of low frequency, repetitive transcranial magnetic stimulation (rTMS) on the lower extremity spasticity and motor neuron excitability in patients after stroke.
Source: Journal of Bodywork and Movement Therapies - October 23, 2014 Category: Physiotherapy Authors: Soofia Naghdi, Noureddin Nakhostin Ansari, Maryam Rastgoo, Bijan Forogh, Shohreh Jalaie, Gholamreza Olyaei Source Type: research

Motor unit number estimation and quantitative needle electromyography in stroke patients
To evaluate the effect of upper motor neuron damage upon motor units’ function by means of two separate and supplementary electrophysiological methods.
Source: Journal of Electromyography and Kinesiology - September 25, 2014 Category: Neurology Authors: Ioanna Kouzi, Eftichia Trachani, Evangelos Anagnostou, Christina-Anastasia Rapidi, John Ellul, George C. Sakellaropoulos, Elisabeth Chroni Source Type: research