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Total 276 results found since Jan 2013.

Pure OCD: a rude awakening
You mentally undress your friends, Tony Blair, the lollipop lady. Your thoughts are X-rated. You wonder if you're a paedophile – or just losing your mind. A sufferer describes the nightmare – and dark comedy – of living with pure OCDOn a spring night when I was 15 the mental image of a naked child entered my head and the corners of my world folded in. I put down my cutlery. My throat was closing over. Dad sat across from me, 10,000 miles away, and Mum was hunting draughts at the window.Stoned and smiling, my brother sat next to me, resting his elbows on teenage knees too high for the table. He looked sidelong at Mum ...
Source: Guardian Unlimited Science - August 31, 2013 Category: Science Tags: The Guardian Psychology Sexuality Mental health & wellbeing Society Features Obsessive-compulsive disorder Life and style Source Type: news

Bill Bowman obituary
Pharmacologist and academic who made a huge contribution in the field of anaesthesiaAnyone who has had a general anaesthetic in the last 40 years has reason to be grateful to Bill Bowman, who has died aged 83. Bill played a pivotal role in both understanding how muscle-relaxing drugs work and developing safer and shorter-acting replacements.A person under anaesthetic twitches alarmingly unless a drug is used for "paralysis" or temporary muscle relaxation. This allows surgery in the chest and abdomen without the need for very deep anaesthesia and makes it possible for a tube to be passed into the windpipe to keep a patient'...
Source: Guardian Unlimited Science - August 20, 2013 Category: Science Authors: Caroline Richmond Tags: theguardian.com Obituaries Medical research Pharmacy and pharmacology Second world war Scotland University of Strathclyde Medicine Education Source Type: news

Regional susceptibility to stress-induced intestinal injury in the mouse.
Abstract Injury to the intestinal mucosa is a life-threatening problem in a variety of clinical disorders, including hemorrhagic shock, trauma, burn, pancreatitis and heat stroke. However, the susceptibility to injury of different regions of intestine in these disorders is not well understood. We compared histological injury across the small intestine in two in vivo mouse models of injury, hemorrhagic shock (30% loss of blood volume) and heat stroke (peak core temperature,42.4°C). In both, areas near the duodenum showed significantly greater mucosal injury and reductions in villi height. To determine if these eff...
Source: Am J Physiol Gastroi... - July 18, 2013 Category: Gastroenterology Authors: Novosad VL, Richards JL, Phillips NA, King MA, Clanton TL Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Increased risk for stroke in burn patients: A population-based one-year follow-up study - Chung SD, Chen CS, Lin HC, Kang JH.
INTRODUCTION: The study aimed to explore the frequency and risk of stroke following hospitalization for burn through the analysis of a population-based dataset in Taiwan. METHODS: We identified 692 hospitalized subjects who had received a diagnosis of burn...
Source: SafetyLit: All (Unduplicated) - July 14, 2013 Category: Global & Universal Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news

If only a Scotsman had boldly gone… | Kevin McKenna
The UK Space Conference opens in Glasgow this week – where better to hold it with all these UFOs around?Like many Scots, I am proud of my country's role in Earth's understanding of outer space. When it first dawned on me as a child that the most important member of Captain James T Kirk's Starship Enterprise was Scottish, I was bursting with pride. Neither do you get to have names such as Neil Armstrong or John Glenn unless there is a significant quotient of Scots blood in you. And when it was revealed many years later that Obi-Wan Kenobi too was Scottish, well… our place in cosmology was finally secured. There have eve...
Source: Guardian Unlimited Science - July 13, 2013 Category: Science Authors: Kevin McKenna Tags: Comment UFOs Star Trek UK news Scotland The Observer Space Comment is free Source Type: news

Increased risk for stroke in burn patients: A population-based one-year follow-up study
Abstract: Introduction: The study aimed to explore the frequency and risk of stroke following hospitalization for burn through the analysis of a population-based dataset in Taiwan.Methods: We identified 692 hospitalized subjects who had received a diagnosis of burn. We randomly selected 2768 comparison subjects to match the study subjects by sex and age group. We individually tracked each subject for one year identifying all those who received a diagnosis of stroke during that period. Cox proportional hazards regressions were performed to calculate the longitudinal hazard of stroke between the two cohorts.Results: We found...
Source: Burns : Journal of the International Society for Burn Injuries - July 8, 2013 Category: Cosmetic Surgery Authors: Shiu-Dong Chung, Chin-Shyan Chen, Herng-Ching Lin, Jiunn-Horng Kang Tags: Articles Source Type: research

Methodology of a reevaluation of cardiovascular outcomes in the RECORD trial: Study design and conduct
Conclusions: Comprehensive procedures were used for rigorous event reascertainment and readjudication in a previously completed open-label, global clinical trial. These procedures used in this unique situation were consistent with other common approaches in the field, were enhanced to address the FDA concerns about the original RECORD trial results, and could be considered by clinical trialists designing event readjudication protocols for drug development programs that have been completed.
Source: American Heart Journal - June 24, 2013 Category: Cardiology Authors: Renato D. Lopes, Sheila Dickerson, Gail Hafley, Shana Burns, Sandra Tourt-Uhlig, Jennifer White, L. Kristin Newby, Michel Komajda, John McMurray, Robert Bigelow, Philip D. Home, Kenneth W. Mahaffey Tags: Trial Design Source Type: research

Paroxysmal Atrial Fibrillation in Cryptogenic Stroke: A Case–Control Study
Conclusions: Very short episodes of PAF are common in patients with CS and with SKC, but their pathogenic significance is unclear. Predominance of PAF in younger patients with CS and embolic infarct pattern suggests a causative role in these cases. More research is needed before prolonged cardiac rhythm monitoring can be recommended to guide anticoagulation in CS patients.
Source: Journal of Stroke and Cerebrovascular Diseases - June 21, 2013 Category: Neurology Authors: Alejandro A. Rabinstein, Jennifer E. Fugate, Jay Mandrekar, Joseph D. Burns, Raymond C.S. Seet, Stefan A. Dupont, Timothy J. Kauffman, Samuel J. Asirvatham, Paul A. Friedman Tags: Original Articles Source Type: research

Results of a reevaluation of cardiovascular outcomes in the RECORD trial
Conclusions: Only a modest number of additional person-years of follow-up were ascertained from this reevaluation of CV end points in RECORD. Observed HRs and CIs from these analyses using the original RECORD or new FDA end point definitions showed similar treatment effects of rosiglitazone compared with the original RECORD results.
Source: American Heart Journal - June 6, 2013 Category: Cardiology Authors: Kenneth W. Mahaffey, Gail Hafley, Sheila Dickerson, Shana Burns, Sandra Tourt-Uhlig, Jennifer White, L. Kristin Newby, Michel Komajda, John McMurray, Robert Bigelow, Philip D. Home, Renato D. Lopes Tags: Diabetes and Metabolism Source Type: research

Non-Bacterial Aortic Valve Vegetation
A 31 year-old man was referred to our hospital for management of a 2cm×2.3cm lesion seen on the left coronary cusp of his aortic valve on transoesophageal echocardiogram (, panel A and B). There was a mild gradient across the aortic valve (mean gradient of 17mmHg) and some mild eccentric aortic regugitation as a consequence of the lesion. Echocardiography had been performed after an ejection systolic murmur was noted by his local medical officer. He denied symptoms of infection or congestive cardiac failure. Routine initial investigations were unremarkable. Multiple sets of blood cultures were negative. Urgent antiphospho...
Source: Heart, Lung and Circulation - May 28, 2013 Category: Cardiology Authors: Sarah Gutman, Andrew Burns Tags: Images Source Type: research

Antithrombin attenuates myocardial dysfunction and reverses systemic fluid accumulation following burn and smoke inhalation injury: a randomized, controlled, experimental study
Conclusions: Based on these findings, the supplementation of rhAT may represent a valuable therapeutic approach for cardiovascular dysfunction and inflammation after burn and smoke inhalation injury.
Source: Critical Care - May 11, 2013 Category: Intensive Care Authors: Sebastian RehbergYusuke YamamotoEva BarthaLinda SousseCollette JonkamYong ZhuLillian TraberRobert CoxDaniel TraberPerenlei Enkhbaatar Source Type: research

Endothelial necrosis at 1 hour postburn predicts progression of tissue injury
Abstract Burn injury progression has not been well characterized at the cellular level. To define burn injury progression in terms of cell death, histopathologic spatiotemporal relationships of cellular necrosis and apoptosis were investigated in a validated porcine model of vertical burn injury progression. Cell necrosis was identified by high mobility group box 1 protein and apoptosis by Caspase 3a staining of tissue samples taken 1 hour, 24 hours, and 7 days postburn. Level of endothelial cell necrosis at 1 hour was predictive of level of apoptosis at 24 hours (Pearson's r = 0.87) and of level of tissue necrosis at ...
Source: Wound Repair and Regeneration - April 29, 2013 Category: Surgery Authors: Douglas Hirth, Steve A. McClain, Adam J. Singer, Richard A. F. Clark Tags: Original Research‐Basic Science Source Type: research

'Dystextia': onset of difficultly writing mobile phone texts determines the time of acute ischaemic stroke allowing thrombolysis.
Abstract PMID: 23625343 [PubMed - as supplied by publisher]
Source: Practical Neurology - April 27, 2013 Category: Neurology Authors: Burns B, Randall M Tags: Pract Neurol Source Type: research

Albumin: Pathophysiologic basis of its role in the treatment of cirrhosis and its complications
Abstract Since the introduction of human serum albumin as a plasma expander in the 1940s, considerable research has allowed a better understanding of its biochemical properties and potential clinical benefits. Albumin has a complex structure, which is responsible for a variety of biological functions. In disease, albumin molecule is susceptible to modifications that may alter its biological activity. During the last decades, different methods to measure albumin function have been developed. Recent studies have shown that not only albumin concentration but also albumin function is reduced in liver failure. This observation ...
Source: Hepatology - February 19, 2013 Category: Internal Medicine Authors: Rita Garcia‐Martinez, Paolo Caraceni, Mauro Bernardi, Pere Gines, Vicente Arroyo, Rajiv Jalan Tags: Liver Failure, Cirrhosis and Portal Hypertension Source Type: research

Prehospital lateral canthotomy
We present the case of a 21-year-old patient who required a prehospital lateral canthotomy following a penetrating injury to the head. This, the first recorded prehospital case, highlights the importance of this simple, potentially sight saving procedure and why it should be in the armamentarium of all prehospital emergency physicians. Background Our patient was treated by the physician staffed Greater Sydney Area Helicopter Emergency Medical Service (GSA-HEMS) from its satellite base 100 km South of Sydney, Australia. GSA-HEMS covers the state of New South Wales providing medical teams for prehospital trauma response...
Source: Emergency Medicine Journal - January 24, 2013 Category: Emergency Medicine Authors: Hill, C., Reid, C., Tzannes, A., Burns, B., Bartlett, M. Tags: Eye Diseases, Coma and raised intracranial pressure, Stroke, Hypertension, Adult intensive care, Resuscitation Reflections on prehospital care Source Type: research