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Induced Pluripotent Stem Cells: The Most Versatile Source for Stem Cell Therapy.
This article describes the advantages and hurdles for the use of induced pluripotent cells as the starting material for a source of replacement cells for regenerative medicine. PMID: 30049501 [PubMed - as supplied by publisher]
Source: Clinical Therapeutics - July 23, 2018 Category: Drugs & Pharmacology Authors: Glicksman MA Tags: Clin Ther Source Type: research

Transporting Patients to Appropriate Receiving Destinations
Conclusion EMS is in a position to be the initiator of specialty center destination. In large cities with multiple hospitals, EMS should transport patients to the closest, most appropriate facility based on patient condition, even if this requires passing a closer facility. Where there are hospitals with multiple specialty services, EMS may be asked to activate a specific team, such as the stroke or cardiac team. In rural communities, EMS can communicate with the local hospital and by letting the hospital know of patient condition, help start the interfacility transport process from the field....
Source: JEMS Special Topics - July 19, 2018 Category: Emergency Medicine Authors: Dennis Edgerly, MEd, EMT-P Tags: Exclusive Articles Columns Operations Source Type: news

Driving After Mild Stroke
In the U.S. over 305,000 people have a mild stroke each year.1 Even mild stroke may lead to difficulties with physical function, thinking, and vision.2 Because of these challenges, people with mild stroke can complete basic tasks fairly easily, but may have difficulty returning to complex tasks like driving.2 Approximately 1 out of every 5 adults with mild stroke report difficulty with driving.3
Source: Archives of Physical Medicine and Rehabilitation - July 17, 2018 Category: Rehabilitation Authors: Hannes Devos, Ickpyo Hong, Amanda Frias, Suzanne Burns, Jaclyn Schwartz, Abiodun Akinwuntan Tags: Organization news Source Type: research

Modeling the impact of changes in tobacco use on individual disease risks
Publication date: August 2018Source: Regulatory Toxicology and Pharmacology, Volume 97Author(s): S. Djurdjevic, Z. Sponsiello-Wang, P.N. Lee, J.S. Fry, R. Weitkunat, F. Lüdicke, G. BakerAbstractReduced Risk Products (RRPs) do not burn tobacco and produce lower levels of toxicants than in cigarette smoke. The long-term effects of using RRPs on health are difficult to assess in a pre-market setting and a modeling approach is required to quantify harm reduction. The Population Health Impact Model (Weitkunat et al., 2015) follows a hypothetical population of individuals over time, creating their tobacco use histories and, bas...
Source: Regulatory Toxicology and Pharmacology - July 11, 2018 Category: Toxicology Source Type: research

Automated monitoring compared to standard care for the early detection of sepsis in critically ill patients.
CONCLUSIONS: It is unclear what effect automated systems for monitoring sepsis have on any of the outcomes included in this review. Very low-quality evidence is only available on automated alerts, which is only one component of automated monitoring systems. It is uncertain whether such systems can replace regular, careful review of the patient's condition by experienced healthcare staff. PMID: 29938790 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - June 25, 2018 Category: General Medicine Authors: Warttig S, Alderson P, Evans DJ, Lewis SR, Kourbeti IS, Smith AF Tags: Cochrane Database Syst Rev Source Type: research

Modeling the impact of changes in tobacco use on individual disease risks
Publication date: Available online 9 June 2018 Source:Regulatory Toxicology and Pharmacology Author(s): S. Djurdjevic, Z. Sponsiello-Wang, P.N. Lee, J.S. Fry, R. Weitkunat, F. Lüdicke, G. Baker Reduced Risk Products (RRPs) do not burn tobacco and produce lower levels of toxicants than in cigarette smoke. The long-term effects of using RRPs on health are difficult to assess in a pre-market setting and a modeling approach is required to quantify harm reduction. The Population Health Impact Model (Weitkunat et al., 2015) follows a hypothetical population of individuals over time, creating their tobacco use histories and, ba...
Source: Regulatory Toxicology and Pharmacology - June 10, 2018 Category: Toxicology Source Type: research

Modeling the impact of changes in tobacco use on individual disease risks.
Abstract Reduced Risk Products (RRPs) do not burn tobacco and produce lower levels of toxicants than in cigarette smoke. The long-term effects of using RRPs on health are difficult to assess in a pre-market setting and a modeling approach is required to quantify harm reduction. The Population Health Impact Model (Weitkunat et al., 2015) follows a hypothetical population of individuals over time, creating their tobacco use histories and, based on these, estimating relative and absolute risks of lung cancer, ischemic heart disease, stroke and chronic obstructive pulmonary disease. Linking the tobacco use to the risk...
Source: Regulatory Toxicology and Pharmacology : RTP - June 9, 2018 Category: Toxicology Authors: Djurdjevic S, Sponsiello-Wang Z, Lee PN, Fry JS, Weitkunat R, Lüdicke F, Baker G Tags: Regul Toxicol Pharmacol Source Type: research

Racial and ethnic disparities in stroke outcomes: a scoping review of post-stroke disability assessment tools.
CONCLUSIONS: A wide variety of assessments are used to examine disparities in post-stroke disability across the time course of stroke recovery. Several studies have identified disparities through a variety of assessments; however, substantial problems abound from the assessments used including inconsistent use of assessments, lacking evidence on the validity of assessments among racial/ethnic groups, and inadequate representation among all racial/ethnic populations comprising the US. Implications for Rehabilitation An enhanced understanding of racial/ethnic disparities in post-stroke disability outcomes is inherently impor...
Source: Disability and Rehabilitation - March 23, 2018 Category: Rehabilitation Authors: Burns SP, White BM, Magwood G, Ellis C, Logan A, Jones Buie JN, Adams RJ Tags: Disabil Rehabil Source Type: research

Interdisciplinary Approaches to Facilitate Return to Driving and Return to Work in Mild Stroke: A Position Paper
Adults with mild stroke face substantial challenges resuming valued roles in the community. The term “mild” provides false representation of the lived experience for many adults with mild stroke who may continue to experience persistent challenges and unmet needs. Rehabilitation practitioners can identify and consequently intervene to facilitate improved independence, participation, and quality of life by facilitating function and reducing the burden of lost abilities among adults with mild stroke.
Source: Archives of Physical Medicine and Rehabilitation - March 5, 2018 Category: Rehabilitation Authors: Suzanne Perea Burns, Jaclyn K. Schwartz, Shannon L. Scott, Hannes Devos, Mark Kovic, Ickpyo Hong, Abiodun Akinwuntan Tags: Special communication Source Type: research

Interdisciplinary Approaches to Facilitate Return-to-Driving and Return-to-Work in Mild Stroke: A Position Paper
Adults with mild stroke face substantial challenges resuming valued roles in the community. The term “mild” provides false representation of the lived experience for many adults with mild stroke who may continue to experience persistent challenges and unmet needs. Rehabilitation practitioners can identify and consequently intervene to facilitate improved independence, participation, and quality of life by facilitating function and reducing the burden of lost abilities among adults with mild stroke.
Source: Archives of Physical Medicine and Rehabilitation - March 5, 2018 Category: Rehabilitation Authors: Suzanne Perea Burns, Jaclyn Schwartz, Shannon Scott, Hannes Devos, Mark Kovic, Ickpyo Hong, Abiodun Akinwuntan Source Type: research

Interdisciplinary Approaches to Facilitate Return to Driving and Return to Work in Mild Stroke: A Position Paper
Adults with mild stroke face substantial challenges resuming valued roles in the community. The term “mild” provides false representation of the lived experience for many adults with mild stroke who may continue to experience persistent challenges and unmet needs. Rehabilitation practitioners can identify and consequently intervene to facilitate improved independence, participation, and quality of life by facilitating function and reducing the burden of lost abilities among adults with mild stroke.
Source: Archives of Physical Medicine and Rehabilitation - March 5, 2018 Category: Rehabilitation Authors: Suzanne Perea Burns, Jaclyn K. Schwartz, Shannon L. Scott, Hannes Devos, Mark Kovic, Ickpyo Hong, Abiodun Akinwuntan Tags: Special communication Source Type: research

Blood vessel occlusion with erythrocyte aggregates causes burn injury progression: microvasculature dilation as a possible therapy
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - February 25, 2018 Category: Dermatology Authors: Richard A. F. Clark, Justine Fenner, Arielle Sasson, Steve A. McClain, Adam J. Singer, Marcia G. Tonnesen Tags: Viewpoint Source Type: research

ESCAPE to Reality, Post-Trial Outcomes in an ESCAPE Centre: A Retrospective Case-Control Study.
Conclusion: ESCAPE eligible patients in our centre had favourable outcome rates superior to the published trial data. ESCAPE ineligible patients tended to do slightly less well, but still better than the favourable outcome rates achieved with IVtPA alone. There is potentially a wide discordance between the threshold for futility and trial eligibility criteria when considering endovascular treatment for acute ischaemic stroke. PMID: 29588552 [PubMed - in process]
Source: The Ulster Medical Journal - January 1, 2018 Category: General Medicine Authors: Nixon AM, Jamison M, Rennie IM, Flynn PA, Smyth G, Wiggam I, Kerr E, Fulton A, Hunter A, Burns PA Tags: Ulster Med J Source Type: research

Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data
Publication date: January 2018 Source:The Lancet Neurology, Volume 17, Issue 1 Author(s): Bruce C V Campbell, Wim H van Zwam, Mayank Goyal, Bijoy K Menon, Diederik W J Dippel, Andrew M Demchuk, Serge Bracard, Philip White, Antoni Dávalos, Charles B L M Majoie, Aad van der Lugt, Gary A Ford, Natalia Pérez de la Ossa, Michael Kelly, Romain Bourcier, Geoffrey A Donnan, Yvo B W E M Roos, Oh Young Bang, Raul G Nogueira, Thomas G Devlin, Lucie A van den Berg, Frédéric Clarençon, Paul Burns, Jeffrey Carpenter, Olvert A Berkhemer, Dileep R Yavagal, Vitor Mendes Pereira, Xavier Ducrocq, Anand Dixit, Helena Quesada, Jonathan E...
Source: The Lancet Neurology - December 16, 2017 Category: Neurology Source Type: research