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Specialty: Cardiology
Condition: Heart Failure
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Total 4537 results found since Jan 2013.
Noncardiac comorbidities and intensive up ‐titration of oral treatment in patients recently hospitalized for heart failure: insights from the STRONG‐HF trial
ConclusionsIn the STRONG-HF trial, non-cardiac comorbidities neither limited the rapid up-titration of HF-therapies, nor attenuated the benefit of HIC on primary endpoint.In the context of a clinical trial, the benefit-risk ratio favors the rapid up-titration of HF-therapies even in patients with multiple NCCsThis article is protected by copyright. All rights reserved.
Source: European Journal of Heart Failure - September 21, 2023 Category: Cardiology Authors: Ovidiu Chioncel,
Beth Davison,
Marianna Adamo,
Laura E Antohi,
Mattia Arrigo,
Marianela Barros,
Jan Biegus,
Kamil ė Čerlinskaitė‐Bajorė,
Jelena Celutkiene,
Alain Cohen‐Solal,
Albertino Damasceno,
Rafael Diaz,
Christopher Edwards,
Gera Tags: Research Article Source Type: research
Role of Vitamins in Cardiovascular Health: Know Your Facts - Part 1
Curr Vasc Pharmacol. 2023 Sep 12. doi: 10.2174/1570161121666230912155548. Online ahead of print.ABSTRACTCardiovascular (CV) disease (CVD) is a major cause of morbidity and mortality world-wide, thus it is important to adopt preventive interventions. Observational data demonstrating CV benefits of vitamin supplements, advanced by self-proclaimed experts have resulted in ~50% of Americans reporting the use of multivitamins for health promotion; this practice has led to a multi-billion-dollar business of the multivitamin-industry. However, the data on the extensive use of multivitamins show no consistent benefit for CVD preve...
Source: Atherosclerosis - September 13, 2023 Category: Cardiology Authors: Antonis A Manolis Theodora A Manolis Helen Melita Antonis S Manolis Source Type: research
The potential predictive value of cardiac mechanics for left ventricular reverse remodelling in dilated cardiomyopathy
ConclusionsPatients with LVRR had a lower LV volume index, lower LVSV index, lower LGE extent, higher LVRI, and preserved myocardial deformation in the longitudinal direction at baseline. LVRI and rGLPS at baseline were independent determinants of LVRR.
Source: ESC Heart Failure - September 12, 2023 Category: Cardiology Authors: Ao Kan,
Qimin Fang,
Shuhao Li,
Wenying Liu,
Xinwei Tao,
Kaiyao Huang,
Mengyao Hu,
Zhaofeng Feng,
Lianggeng Gong Tags: Original Article Source Type: research
Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility
AbstractThe ketone body 3-hydroxybutyrate (3-OHB) increases cardiac output and myocardial perfusion without affecting blood pressure in humans, but the cardiovascular sites of action remain obscure. Here, we test the hypothesis in rats that 3-OHB acts directly on the heart to increase cardiac contractility and directly on blood vessels to lower systemic vascular resistance. We investigate effects of 3-OHB on (a) in vivo hemodynamics using echocardiography and invasive blood pressure measurements, (b) isolated perfused hearts in Langendorff systems, and (c) isolated arteries and veins in isometric myographs. We compare Na-3...
Source: Basic Research in Cardiology - September 9, 2023 Category: Cardiology Source Type: research
Blocking interleukin-6 Trans-Signaling in AF: Promises and Challenges
Atrial fibrillation (AF) stands as the most prevalent cardiovascular disease, posing significant risks of stroke, heart failure, and other complications that contribute to morbidity and mortality. While traditionally research on AF has primarily focused on electrophysiological components like ionic currents and the Ca2+ handling system, treatment strategies have mainly revolved around the rate-limiting beta-blockers and Ca2+ channel blockers, or rhythm-control methods such as cardioversion, antiarrhythmics, and catheter ablation.
Source: Heart Rhythm - September 9, 2023 Category: Cardiology Authors: Enrique Martinez, Na Li Source Type: research
Correlation of neck circumference, coronary calcification severity and cardiovascular events in Chinese elderly patients with acute coronary syndromes
CONCLUSIONS: NC is closely associated with MetS and its components, coronary calcification and lesion degree, and MACEs. NC could be used as surrogate of CACS to predict the coronary condition and prognosis of elderly patients with ACS.PMID:37679211 | DOI:10.1016/j.atherosclerosis.2023.117242
Source: Atherosclerosis - September 7, 2023 Category: Cardiology Authors: Peiqing Tian Yixuan Liu Jiayu Wang Liyun Xing Xianwei Huang Caihua Fu Cuicui Yuan Ping Liu Source Type: research
Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways
In this study, we investigated the anti-ferroptosis effects of suberosin (SBR; a prenylated coumarin) in diabetic Sprague Dawley rats. Further, we assessed the effects of co-administration of SBR (30 and 90 mg/kg/day) with thiazolidinedione (TZ at 15 mg/kg) to mitigate TZ-induced cardiomyopathy in diabetic rats. Our results showed that cardiac output, stroke volume, left ventricle systolic and diastolic pressures were aggravated in diabetic rats treated with TZ alone after 4 weeks. TZ treatments induced ferroptosis as well as marked histoarchitecture disarrangements in rat cardiomyocytes. The study found that optimizing vo...
Source: Cardiovascular Toxicology - September 7, 2023 Category: Cardiology Authors: Shabnoor Iqbal Farhat Jabeen Ivan Kahwa Timothy Omara Source Type: research
Causal associations between type 1 diabetes mellitus and cardiovascular diseases: a Mendelian randomization study
CONCLUSION: This MR study provided evidence supporting the causal effect of T1DM on peripheral atherosclerosis and coronary atherosclerosis, with hypertension partly mediating this effect.PMID:37659996 | PMC:PMC10475187 | DOI:10.1186/s12933-023-01974-6
Source: Atherosclerosis - September 2, 2023 Category: Cardiology Authors: Zirui Liu Haocheng Wang Zhengkai Yang Yu Lu Cao Zou Source Type: research
Early Aortic Valve Replacement in Symptomatic Normal-Flow, Low-Gradient Severe Aortic Stenosis: A Propensity Score-Matched Retrospective Cohort Study
CONCLUSIONS: An early AVR strategy may be beneficial in reducing the risk of a composite outcome of death or hospitalization for HF in symptomatic patients with NFLG severe AS. Future randomized studies are required to validate and confirm our findings.PMID:37653715 | DOI:10.4070/kcj.2023.0022
Source: Korean Circulation Journal - September 1, 2023 Category: Cardiology Authors: Kyu Kim Iksung Cho Kyu-Yong Ko Seung-Hyun Lee Sak Lee Geu-Ru Hong Jong-Won Ha Chi Young Shim Source Type: research
Comparison of serum lipoprotein(a) levels in young and middle-aged patients presenting for the first time with ST-elevation myocardial infarction: a single-centre study
CONCLUSION: Lp(a) level was found to be a higher and a possible independent risk factor in young patients who presented with STEMI for the first time, compared to the middle-aged patient group. Lp(a) is a highly atherogenic molecule and it has been associated with stroke, heart failure, aortic stenosis, as well as coronary artery disease. Measurement of Lp(a) levels may be recommended in young patients with high cardiovascular risk.PMID:37656600 | DOI:10.5830/CVJA-2023-038
Source: Cardiovascular Journal of Africa - September 1, 2023 Category: Cardiology Authors: Song ül Usalp Emine Altunta ş Bayram Ba ğırtan Kanber Ö Karabay Source Type: research
