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Condition: Heart Failure
Infectious Disease: HIV AIDS

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Total 17 results found since Jan 2013.

Cardiopulmonary interactions —which monitoring tools to use?
Heart-lung interactions occur due to the mechanical influence of intrathoracic pressure and lung volume changes on cardiac and circulatory function. These interactions manifest as respiratory fluctuations in venous, pulmonary, and arterial pressures, potentially affecting stroke volume. In the context of functional hemodynamic monitoring, pulse or stroke volume variation (pulse pressure variation or stroke volume variability) are commonly employed to assess volume or preload responsiveness. However, correct interpretation of these parameters requires a comprehensive understanding of the physiological factors that determine...
Source: Frontiers in Physiology - August 9, 2023 Category: Physiology Source Type: research

Incidence of cardiometabolic outcomes among people living with HIV-1 initiated on integrase strand transfer inhibitor versus non-integrase strand transfer inhibitor antiretroviral therapies: a retrospective analysis of insurance claims in the United States
CONCLUSIONS: Over a short average follow-up period of <2 years, INSTI use among treatment-naïve PLWH was associated with an increased risk of several cardiometabolic outcomes, such as CHF, myocardial infarction and lipid disorders, compared to non-INSTI use. Further research accounting for additional potential confounders and with longer follow-up is warranted to more accurately and precisely quantify the impact of INSTI-containing ART on long-term cardiometabolic outcomes.PMID:37306118 | PMC:PMC10258864 | DOI:10.1002/jia2.26123
Source: Journal of the International AIDS Society - June 12, 2023 Category: Infectious Diseases Authors: Peter F Rebeiro Bruno Emond Carmine Rossi Brahim K Bookhart Aditi Shah Gabrielle Caron-Lapointe Marie-H élène Lafeuille Prina Donga Source Type: research

Heart failure with reduced ejection fraction and atrial fibrillation: a Sub ‐Saharan African perspective
AbstractCardiovascular diseases are a well-established cause of death in high-income countries. In the last 20  years, Sub-Saharan Africa (SSA) has seen one of the sharpest increases in cardiovascular disease-related mortality, superseding that of infectious diseases, including HIV/AIDS, in South Africa. This increase is evidenced by a growing burden of heart failure and atrial fibrillation (AF) risk factor s. AF is a common comorbidity of heart failure with reduced ejection fraction (HFrEF), which predisposes to an increased risk of stroke, rehospitalizations, and mortality compared with patients in sinus rhythm. AF had ...
Source: ESC Heart Failure - March 20, 2023 Category: Cardiology Authors: Nonkanyiso Mboweni, Muzi Maseko, Nqoba Tsabedze Tags: Review Source Type: research

Cardiovascular disease risk in women living with HIV
Purpose of review To synthesize current evidence on the impact of cardiovascular disease among women living with HIV (WLWH) with a particular focus on disease prevalence, mechanisms and prevention. Recent findings HIV-related cardiovascular disease risk is 1.5-fold to 2-fold higher for women than for men. Mechanisms of enhanced risk are multifactorial and include reinforcing pathways between traditional risk factors, metabolic dysregulation, early reproductive aging and chronic immune activation. These pathways influence both the presentation of overt syndromes of myocardial infarction, stroke and heart failure,...
Source: Current Opinion in HIV and AIDS - August 18, 2022 Category: Infectious Diseases Tags: CARDIOVASCULAR DISEASE: Edited by Virginia A. Triant Source Type: research

Association of Syndemic Unhealthy Alcohol Use, Smoking, and Depressive Symptoms on Incident Cardiovascular Disease among Veterans With and Without HIV-Infection
AbstractUnhealthy alcohol use, smoking, and depressive symptoms are risk factors for cardiovascular disease (CVD). Little is known about their co-occurrence – termed a syndemic, defined as the synergistic effect of two or more conditions—on CVD risk in people with HIV (PWH). We used data from 5621 CVD-free participants (51% PWH) in the Veteran’s Aging Cohort Study-8, a prospective, observational study of veterans followed from 2002 to 2014 to asse ss the association between this syndemic and incident CVD by HIV status. Diagnostic codes identified cases of CVD (acute myocardial infarction, stroke, heart failure, perip...
Source: AIDS and Behavior - August 19, 2021 Category: Infectious Diseases Source Type: research

Management of cardiovascular diseases in HIV/AIDS patients
AbstractHuman immunodeficiency virus  (HIV) infection/acquired immunodeficiency syndrome, a pandemic in the current population causes severe weakness of the body's immune system making the infected patient more vulnerable to life‐threatening conditions. The disease predisposes the infected patient to several cardiovascular diseases and cerebrovascular diseases such as heart failure and stroke. The decline in CD4 cells following HIV infection, vulnerability to opportunistic infections and underlying HIV pathology plays a major role in the development of cardiovascular manifestations, and treatment targeting cardiomyopath...
Source: Journal of Cardiac Surgery - November 22, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Santoshi K. Ashwitha, Preethi A. Jacob, Abdullah Ajaj, Manasi M. Shirke, Amer Harky Tags: REVIEW ARTICLE Source Type: research

Genotype-phenotype associations in atrial fibrillation: meta-analysis
ConclusionsPooled analysis showed a significantly high prevalence of stroke (10%) inRS2200733 AF patients. AF patients with the studied SNPs had preserved left ventricular systolic function (i.e., ejection fraction greater than 50%). AF patients withRS10033464 presented larger left atrium diameter (44  mm (95% CI 42.02–45.98)) than those with other SNPs. The late AF recurrence rate was highest inRS2200733 patients (53% (95% CI 0.43 –0.64)). This study aids our understanding of the existing genetic findings and the function-altering “strongest” SNPs.
Source: Journal of Interventional Cardiac Electrophysiology - November 17, 2018 Category: Cardiology Source Type: research

HIV and Cardiovascular Disease: Update on Clinical Events, Special Populations, and Novel Biomarkers
The objective of this review is to provide an update on the link between HIV infection and cardiovascular disease (CVD). We will focus our review mainly on literature describing clinical CVD events and understudied topics of importance.Recent FindingsHeart failure, peripheral artery disease, and stroke are CVD modalities deserving more attention in the context of HIV infection in the highly active antiretroviral therapy era. Incidence data on clinical CVD from HIV populations in low- and middle-income countries are limited. Multisubstance use is common in HIV, but understudied as a moderator or mediator of the association ...
Source: Current HIV/AIDS Reports - June 1, 2018 Category: Infectious Diseases Source Type: research

Cardiovascular disease risk among women living with HIV in North America and Europe
Purpose of review To examine the epidemiology and mechanistic underpinnings of heightened cardiovascular disease (CVD) risk among women living with HIV (WLHIV) in North America and Europe. Recent findings WLHIV in North America and Europe exhibit high CVD incidence rates, which are at par with those of compatriot men living with HIV. Compared with uninfected women, WLHIV in these regions face a 2–4-fold increased relative risk for myocardial infarction, stroke, and heart failure. HIV-associated CVD risk is fuelled by a negative synergy of traditional cardiometabolic risk factors and heightened systemic immune activa...
Source: Current Opinion in HIV and AIDS - November 1, 2017 Category: Infectious Diseases Tags: CARDIOVASCULAR DISEASE IN HIV INFECTED PERSONS: Edited by Franck Boccara and Cameron J. Holloway Source Type: research

Factors Mediating Outcome After Stroke: Gender, Thrombolysis, and Their Interaction
AbstractSeveral studies, but not all, have shown that women benefit more from intravenous thrombolysis than men; few have accounted for pre-stroke mobility. Our aim was to determine whether there was an interaction between gender and thrombolysis treatment in 3-month modified Rankin Scale (mRS) score, after adjusting for pre-stroke mobility. We retrospectively reviewed medical records of 1390 consecutive ischemic stroke patients admitted between October 2012 and July 2015. The 3-month mRS was obtained from clinic visits. Thrombolysis-by-gender interaction was evaluated in univariate and multivariate analyses using ordinal ...
Source: Translational Stroke Research - October 24, 2017 Category: Neurology Source Type: research

Cardiovascular disease risk among women living with HIV in North America and Europe
Purpose of review: To examine the epidemiology and mechanistic underpinnings of heightened cardiovascular disease (CVD) risk among women living with HIV (WLHIV) in North America and Europe. Recent findings: WLHIV in North America and Europe exhibit high CVD incidence rates, which are at par with those of compatriot men living with HIV. Compared with uninfected women, WLHIV in these regions face a 2–4-fold increased relative risk for myocardial infarction, stroke, and heart failure. HIV-associated CVD risk is fuelled by a negative synergy of traditional cardiometabolic risk factors and heightened systemic immune activati...
Source: Current Opinion in HIV and AIDS - October 7, 2017 Category: Infectious Diseases Tags: CARDIOVASCULAR DISEASE IN HIV INFECTED PERSONS: Edited by Franck Boccara and Cameron J. Holloway Source Type: research

Delivery of health care for cardiovascular and metabolic diseases among people living with HIV/AIDS in African countries: a systematic review protocol
We present a systematic review protocol to synthesize studies of healthcare delivery for an important subset of NCDs, cardiovascular and metabolic diseases (CMDs), among African PLHIV. Methods/design We plan to search electronic databases and reference lists of relevant studies published in African settings from January 2003 to the present. Studies will be considered if they address one or both of our major objectives and focus on health care for one or more of six interrelated CMDs (ischemic heart disease, stroke, heart failure, hypertension, diabetes, and hyperlipidemia) in PLH...
Source: Systematic Reviews - April 15, 2016 Category: Global & Universal Source Type: research