Genotype-phenotype associations in atrial fibrillation: meta-analysis

ConclusionsPooled analysis showed a significantly high prevalence of stroke (10%) inRS2200733 AF patients. AF patients with the studied SNPs had preserved left ventricular systolic function (i.e., ejection fraction greater than 50%). AF patients withRS10033464 presented larger left atrium diameter (44  mm (95% CI 42.02–45.98)) than those with other SNPs. The late AF recurrence rate was highest inRS2200733 patients (53% (95% CI 0.43 –0.64)). This study aids our understanding of the existing genetic findings and the function-altering “strongest” SNPs.
Source: Journal of Interventional Cardiac Electrophysiology - Category: Cardiology Source Type: research