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Specialty: Drugs & Pharmacology
Condition: Headache
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Total 50 results found since Jan 2013.
The Role of Xanthine Oxidase Inhibitors in Patients with History of Stroke: A Systematic Review.
CONCLUSION: Based on the reviewed literature, allopurinol appears to be a promising therapy to improve vascular function and reduce disability in patients who have had a stroke. The benefits seen are in combination with current standard of care treatments with aspirin and lipid-lowering therapy. Larger trials are necessary to better understand the role of allopurinol in patients with history of stroke.
PMID: 28933307 [PubMed - as supplied by publisher]
Source: Current Vascular Pharmacology - September 19, 2017 Category: Drugs & Pharmacology Authors: Britnell SR, Chillari KA, Brown JN Tags: Curr Vasc Pharmacol Source Type: research
Effects of total saponins from Trillium tschonoskii rhizome on grey and white matter injury evaluated by quantitative multiparametric MRI in a rat model of ischemic stroke
Conclusion Our results suggested the potential protective and repair-promoting effects of TSTT on grey and white matter from damage induced by ischemia. This study provides a modern pharmacological basis for the application of TSTT in managing ischemic stroke. Graphical abstract
Source: Journal of Ethnopharmacology - January 12, 2018 Category: Drugs & Pharmacology Source Type: research
Worsening migraines in women using HRT indicate increased risk of stroke
Worsening migraines in users of hormone replacement therapy is associated with an increased risk of ischaemic stroke, according to a new study.
Source: The Pharmaceutical Journal - February 25, 2016 Category: Drugs & Pharmacology Source Type: research
Study questions perceived stroke risk of some migraine drugs
Triptans and dihydroergotamine can be used to treat basilar and hemiplegic migraine without an increased risk of stroke, according to research published in the May 2016 issue of Headache.
Source: The Pharmaceutical Journal - May 19, 2016 Category: Drugs & Pharmacology Source Type: research
Role of TREK-1 in Health and Disease, Focus on the Central Nervous System
Conclusion and Perspectives
Since their cloning 20 years ago, the physiological importance of TREK-1 channels has continued to grow (Figure 3). Today, TREK-1 channels have been shown to be important and their presence is essential in a number of physiopathological processes. Their involvement in these different processes demonstrate the necessity to design pharmacological modulators, activators or inhibitors, of these channels to correct any TREK-1-related dysfunctions.
Despites a number of studies and many molecule screenings, only few putative new drugs were identified. The activators belonging to the ML and BL series ...
Source: Frontiers in Pharmacology - April 10, 2019 Category: Drugs & Pharmacology Source Type: research
Bergapten attenuates microglia-mediated neuroinflammation and ischemic brain injury by targeting Kv1.3 and Carbonyl reductase 1
Eur J Pharmacol. 2022 Sep 1:175242. doi: 10.1016/j.ejphar.2022.175242. Online ahead of print.ABSTRACTMicroglia-mediated neuroinflammation plays a vital role in the pathogenesis of ischemic stroke, which serves as a prime target for developing novel therapeutic agent. However, feasible and effective agents for controlling neuroinflammation are scarce. Bergapten were acknowledged to hold therapeutic potential in restricting inflammation in multiple diseases, including peripheral neuropathy, migraine headaches and osteoarthritis. Here, we aimed to investigate the impact of bergapten on microglia-mediated neuroinflammation and...
Source: European Journal of Pharmacology - September 4, 2022 Category: Drugs & Pharmacology Authors: Shenghan Gao Xinxin Zou Zibu Wang Xin Shu Xiang Cao Shengnan Xia Pengfei Shao Xinyu Bao Haiyan Yang Yun Xu Pinyi Liu Source Type: research
Efficacy of trazodone for treating paroxysmal sympathetic hyperactivity presenting after thalamic hemorrhage: A case report.
Authors: Morinaga Y, Nii K, Sakamoto K, Inoue R, Mitsutake T, Hanada H
Abstract
Paroxysmal sympathetic hyperactivity (PSH) is a clinical condition characterized by abnormal paroxysmal surges in sympathetic nervous system activity. PSH is known to occur after severe head injury and hypoxic encephalopathy. Cases of PSH that develop after stroke have been reported worldwide; however, PSH is not commonly reported in the field of stroke research in Japan. Some studies have suggested that gabapentin may improve the symptoms of PSH. To our knowledge, this is the first case report demonstrating the efficacy of trazodone fo...
Source: Drug Discoveries and Therapeutics - July 23, 2019 Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
Spreading Depolarization Waves in Neurological Diseases: A Short Review about its Pathophysiology and Clinical Relevance.
Abstract
Lesion growth following acutely injured brain tissue after stroke, subarachnoid hemorrhage and traumatic brain injury is an important issue and a new target area for promising therapeutic interventions. Spreading depolarization or peri-lesion depolarization waves were demonstrated as one of the significant contributors of continued lesion growth. In this short review, we discuss the pathophysiology for SD forming events and try to list findings detected in neurological disorders like migraine, stroke, subarachnoid hemorrhage and traumatic brain injury in both human as well as experimental studies. Pharmac...
Source: Current Neuropharmacology - September 15, 2017 Category: Drugs & Pharmacology Authors: Taş YÇ, Solaroğlu İ, Gürsoy-Özdemir Y Tags: Curr Neuropharmacol Source Type: research
Brain Peptides for the Treatment of Neuropsychiatric Disorders.
Abstract
The realization of the importance of growth factors in adult CNS led to several studies investigating their roles in neuropsychiatric disorders. Based on the observations that chronic stress decreases brain-derived neurotrophic factor (BDNF) and antidepressant treatments reverse BDNF to normal levels, "neurotrophic hypothesis of depression" was proposed. Subsequent studies found that several other growth factors, including fibroblast growth factor (FGF), vascular endothelial growth factor, nerve growth factor were also decreased by chronic stress. Growth factors promote stem cell survival, angiogenesis an...
Source: Current Pharmaceutical Design - November 11, 2018 Category: Drugs & Pharmacology Authors: Karatas H, Yemisci M, Eren-Kocak E, Dalkara T Tags: Curr Pharm Des Source Type: research
In Brief: Tegaserod (Zelnorm) Returns
Date: May 6, 2019
Issue #:
1571Summary:
Tegaserod maleate(Zelnorm), a 5-HT4 receptor partial agonist that increases gastrointestinal (GI) motility, was approved by the FDA in 2002 for short-term treatment of irritable bowel syndrome with constipation (IBS-C) in women and in 2004 for treatment of chronic idiopathic constipation (CIC) in adults<65 years old.In 2007, the manufacturer (Novartis) complied with an FDA request to stop marketing the drug based on an unpublished retrospective analysis of clinical trials in IBS-C and other GI motility disorders that showed a higher rate of ischemic ...
Source: The Medical Letter - April 26, 2019 Category: Drugs & Pharmacology Authors: admin Tags: Constipation irritable bowel syndrome Motegrity prucalopride Resotran Tegaserod Zelnorm Source Type: research
Neuronal and Cerebrovascular Complications in Coronavirus Disease 2019
Coronavirus disease 2019 (COVID-19) is a pandemic disease resulting from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, primarily in the respiratory tract. This pandemic disease has affected the entire world, and the pathobiology of this disease is not yet completely known. The Interactions of SARS-CoV-2 proteins with different cellular components in the host cell may be necessary for understanding the disease mechanism and identifying crucial pharmacological targets in COVID-19. Studies have suggested that the effect of SARS-CoV-2 on other organs, including the brain, maybe critical for understand...
Source: Frontiers in Pharmacology - November 20, 2020 Category: Drugs & Pharmacology Source Type: research
Potential therapeutics against neurological disorders: Natural products-based drugs
Neurodegenerative disorders, which are defined by the breakdown of neurons over time, are affecting an increasing number of people. Stroke, Alzheimer's, Parkinson's, Multiple Sclerosis, Migraine, and Amyotrophic Lateral Sclerosis are just a few examples of brain disorders that have no cure. Besides, there is a huge demand for drugs that can cure the diseases mentioned above because the majority of the medications we use to treat them only alleviate diseases. Different neurological disorders have responded satisfactorily to the pharmacological effects of medicinal plants. Despite the numerous multiple types of plants in the...
Source: Frontiers in Pharmacology - August 19, 2022 Category: Drugs & Pharmacology Source Type: research
Safety, pharmacokinetics and pharmacodynamics of multiple oral doses of apixaban, a factor Xa inhibitor, in healthy subjects
This study examined the safety, pharmacokinetics and pharmacodynamics of multiple‐dose apixaban.
MethodsThis double‐blind, randomized, placebo‐controlled, parallel‐group, multiple‐dose escalation study was conducted in six sequential dose panels – apixaban 2.5, 5, 10 and 25 mg twice daily (BID) and 10 and 25 mg once daily (QD) – with 8 healthy subjects per panel. Within each panel, subjects were randomized (3:1) to oral apixaban or placebo for 7 days. Subjects underwent safety assessments and were monitored for adverse events (AEs). Blood samples were taken to measure apixaban plasma concentration, internatio...
Source: British Journal of Clinical Pharmacology - March 4, 2013 Category: Drugs & Pharmacology Authors: Charles Frost, Sunil Nepal, Jessie Wang, Alan Schuster, Wonkyung Byon, Rebecca A. Boyd, Zhigang Yu, Andrew Shenker, Yu Chen Barrett, Rogelio Mosqueda‐Garcia, Frank LaCreta Tags: PK‐PD Relationships Source Type: research
Neurochemicals involved in medullary control of common carotid blood flow.
Abstract
The common carotid artery (CCA) supplies intra- and extra-cranial vascular beds. An area in the medulla controlling CCA blood flow is defined as the dorsal facial area (DFA) by Kuo et al. in 1987. In the DFA, presynaptic nitrergic and/or glutamatergic fibers innervate preganglionic nitrergic and/or cholinergic neurons which give rise to the preganglionic fibers of the parasympathetic 7th and 9th cranial nerves. Released glutamate from presynaptic nitrergic and/or glutamatergic fibers can activate N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors on preg...
Source: Current Neuropharmacology - September 1, 2013 Category: Drugs & Pharmacology Authors: Gong CL, Leung YM, Wang MR, Lin NN, Lee TJ, Kuo JS Tags: Curr Neuropharmacol Source Type: research
Potential mechanisms of prospective antimigraine drugs: A focus on vascular (side) effects
Publication date: March 2011 Source:Pharmacology & Therapeutics, Volume 129, Issue 3 Author(s): Kayi Y. Chan , Steve Vermeersch , Jan de Hoon , Carlos M. Villalón , Antoinette MaassenVanDenBrink Currently available drugs for the acute treatment of migraine, i.e. ergot alkaloids and triptans, are cranial vasoconstrictors. Although cranial vasoconstriction is likely to mediate—at least a part of—their therapeutic effects, this property also causes vascular side-effects. Indeed, the ergot alkaloids and the triptans have been reported to induce myocardial ischemia and stroke, albeit in extremely rare cases, and ...
Source: Pharmacology and Therapeutics - November 6, 2014 Category: Drugs & Pharmacology Source Type: research
