Spreading Depolarization Waves in Neurological Diseases: A Short Review about its Pathophysiology and Clinical Relevance.

Spreading Depolarization Waves in Neurological Diseases: A Short Review about its Pathophysiology and Clinical Relevance.
Curr Neuropharmacol. 2017 Sep 15;:
Authors: Taş YÇ, Solaroğlu İ, Gürsoy-Özdemir Y
Abstract
Lesion growth following acutely injured brain tissue after stroke, subarachnoid hemorrhage and traumatic brain injury is an important issue and a new target area for promising therapeutic interventions. Spreading depolarization or peri-lesion depolarization waves were demonstrated as one of the significant contributors of continued lesion growth. In this short review, we discuss the pathophysiology for SD forming events and try to list findings detected in neurological disorders like migraine, stroke, subarachnoid hemorrhage and traumatic brain injury in both human as well as experimental studies. Pharmacological and non-pharmacological treatment strategies are highlighted and future directions and research limitations are discussed.
PMID: 28925885 [PubMed - as supplied by publisher]

Source: Current Neuropharmacology - September 15, 2017 Category: Drugs & Pharmacology Authors: Taş YÇ, Solaroğlu İ, Gürsoy-Özdemir Y Tags: Curr Neuropharmacol Source Type: research